Five-year outcome of respiratory muscle weakness at intensive care unit discharge: secondary analysis of a prospective cohort study.
Aged
Critical Care
/ methods
Disease Progression
Female
Follow-Up Studies
Humans
Intensive Care Units
/ statistics & numerical data
Male
Middle Aged
Muscle Strength
/ physiology
Muscle Weakness
/ etiology
Patient Discharge
/ trends
Prognosis
Prospective Studies
Quality of Life
Respiratory Insufficiency
/ complications
Respiratory Muscles
/ physiopathology
Risk Factors
Surveys and Questionnaires
Time Factors
critical care
pulmonary rehabilitation
respiratory muscles
Journal
Thorax
ISSN: 1468-3296
Titre abrégé: Thorax
Pays: England
ID NLM: 0417353
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
08
12
2020
revised:
02
02
2021
accepted:
18
02
2021
pubmed:
14
3
2021
medline:
14
7
2021
entrez:
13
3
2021
Statut:
ppublish
Résumé
To assess the association between respiratory muscle weakness (RMW) at intensive care unit (ICU) discharge and 5-year mortality and morbidity, independent from confounders including peripheral muscle strength. Secondary analysis of the prospective 5-year follow-up of the EPaNIC cohort (ClinicalTrials.gov: NCT00512122), limited to 366 patients screened for respiratory and peripheral muscle strength in the ICU with maximal inspiratory pressure (MIP) after removal of the artificial airway, and the Medical Research Council sum score. RMW was defined as an absolute value of MIP <30 cmH RMW was present in 136/366 (37.2%) patients at ICU discharge. RMW was not independently associated with 5-year mortality (HR with 95% CI 1.273 (0.751 to 1.943), p=0.352). Among 156five-year survivors, those with, as compared with those without RMW demonstrated worse physical function (MIP (absolute value, cmH RMW at ICU discharge is independently associated with 5-year morbidity but not 5-year mortality.
Identifiants
pubmed: 33712505
pii: thoraxjnl-2020-216720
doi: 10.1136/thoraxjnl-2020-216720
doi:
Banques de données
ClinicalTrials.gov
['NCT00512122']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
561-567Informations de copyright
© Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.