Evidences for lipid involvement in SARS-CoV-2 cytopathogenesis.
Animals
COVID-19
/ metabolism
Chlorocebus aethiops
Cytopathogenic Effect, Viral
Humans
Lipid Droplets
/ ultrastructure
Lipid Metabolism
Lung
/ metabolism
Severe acute respiratory syndrome-related coronavirus
/ metabolism
SARS-CoV-2
/ metabolism
Severe Acute Respiratory Syndrome
/ metabolism
Vero Cells
Journal
Cell death & disease
ISSN: 2041-4889
Titre abrégé: Cell Death Dis
Pays: England
ID NLM: 101524092
Informations de publication
Date de publication:
12 03 2021
12 03 2021
Historique:
received:
14
12
2020
accepted:
08
02
2021
revised:
08
02
2021
entrez:
13
3
2021
pubmed:
14
3
2021
medline:
23
3
2021
Statut:
epublish
Résumé
The pathogenesis of SARS-CoV-2 remains to be completely understood, and detailed SARS-CoV-2 cellular cytopathic effects requires definition. We performed a comparative ultrastructural study of SARS-CoV-1 and SARS-CoV-2 infection in Vero E6 cells and in lungs from deceased COVID-19 patients. SARS-CoV-2 induces rapid death associated with profound ultrastructural changes in Vero cells. Type II pneumocytes in lung tissue showed prominent altered features with numerous vacuoles and swollen mitochondria with presence of abundant lipid droplets. The accumulation of lipids was the most striking finding we observed in SARS-CoV-2 infected cells, both in vitro and in the lungs of patients, suggesting that lipids can be involved in SARS-CoV-2 pathogenesis. Considering that in most cases, COVID-19 patients show alteration of blood cholesterol and lipoprotein homeostasis, our findings highlight a peculiar important topic that can suggest new approaches for pharmacological treatment to contrast the pathogenicity of SARS-CoV-2.
Identifiants
pubmed: 33712574
doi: 10.1038/s41419-021-03527-9
pii: 10.1038/s41419-021-03527-9
pmc: PMC7952828
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
263Subventions
Organisme : Regione Lazio (Region of Lazio)
ID : E56C18000460002
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