What is the optimal initial dose of epinephrine during neonatal resuscitation in the delivery room?
Journal
Journal of perinatology : official journal of the California Perinatal Association
ISSN: 1476-5543
Titre abrégé: J Perinatol
Pays: United States
ID NLM: 8501884
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
01
12
2020
accepted:
25
02
2021
revised:
29
01
2021
pubmed:
14
3
2021
medline:
21
10
2021
entrez:
13
3
2021
Statut:
ppublish
Résumé
The neonatal resuscitation program recommends a wide dose range of epinephrine for newborns who receive chest compressions (endotracheal tube [ET] dose of 0.05-0.1 mg/kg or intravenous [IV] dose of 0.01-0.03 mg/kg), which presents a challenge to neonatal care providers when attempting to determine the optimal initial dose. Dosing errors are common when preparing epinephrine for neonatal resuscitation. Based on animal data, we suggest preparing 0.1 mg/kg or 1 ml/kg of 1 mg/10 ml epinephrine in a 5 ml syringe for ET administration. For IV epinephrine, we suggest preparing an initial dose of 0.02 mg/kg or 0.2 ml/kg of 1 mg/10 ml epinephrine in a 1 ml syringe. A dose of 0.02 mg/kg enables use of a 1 ml syringe for a wide range of birth weights from 500 g to 5 kg. The use of a color-coded syringe may decrease errors in dose preparation.
Identifiants
pubmed: 33712718
doi: 10.1038/s41372-021-01032-7
pii: 10.1038/s41372-021-01032-7
doi:
Substances chimiques
Epinephrine
YKH834O4BH
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1769-1773Subventions
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : HD096299
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : HD072929
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Nature America, Inc.
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