The expression of P2Y
Animals
Colitis
/ chemically induced
Dextran Sulfate
/ toxicity
Gene Expression Regulation
/ genetics
Goblet Cells
/ drug effects
Humans
Inflammatory Bowel Diseases
/ chemically induced
Intestinal Mucosa
/ drug effects
Intestines
/ drug effects
Mice
Mice, Knockout
Mucins
/ genetics
Mucus
/ drug effects
Receptors, Purinergic P2
/ genetics
IBD
P2Y6
intestinal inflammation
mucus
nucleotides
Journal
The FEBS journal
ISSN: 1742-4658
Titre abrégé: FEBS J
Pays: England
ID NLM: 101229646
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
22
07
2020
accepted:
11
03
2021
pubmed:
14
3
2021
medline:
29
9
2021
entrez:
13
3
2021
Statut:
ppublish
Résumé
In the intestine, mucins are expressed and secreted by goblet cells and enterocytes in a constitutive manner and in response to secretagogues to form a protective mucus layer. This protective barrier is often lost in inflammatory bowel disease (IBD). Interestingly, extracellular nucleotides, through P2Y receptors, were identified as mucin secretagogues in mucinous epithelia. These nucleotides are found in the intestine's extracellular milieu under basal conditions and in higher concentrations in pathologies such as IBD. It was observed that the mucus layer was affected in P2ry6 knockout mice suffering from dextran sodium sulfate (DSS)-induced colitis. P2ry6
Substances chimiques
Mucins
0
Receptors, Purinergic P2
0
purinoceptor P2Y6
0
sulfomucin
0
Dextran Sulfate
9042-14-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5459-5473Informations de copyright
© 2021 Federation of European Biochemical Societies.
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