Ribosome states signal RNA quality control.
Journal
Molecular cell
ISSN: 1097-4164
Titre abrégé: Mol Cell
Pays: United States
ID NLM: 9802571
Informations de publication
Date de publication:
01 04 2021
01 04 2021
Historique:
received:
19
11
2020
revised:
04
02
2021
accepted:
17
02
2021
pubmed:
14
3
2021
medline:
15
4
2021
entrez:
13
3
2021
Statut:
ppublish
Résumé
Eukaryotic cells integrate multiple quality control (QC) responses during protein synthesis in the cytoplasm. These QC responses are signaled by slow or stalled elongating ribosomes. Depending on the nature of the delay, the signal may lead to translational repression, messenger RNA decay, ribosome rescue, and/or nascent protein degradation. Here, we discuss how the structure and composition of an elongating ribosome in a troubled state determine the downstream quality control pathway(s) that ensue. We highlight the intersecting pathways involved in RNA decay and the crosstalk that occurs between RNA decay and ribosome rescue.
Identifiants
pubmed: 33713598
pii: S1097-2765(21)00132-5
doi: 10.1016/j.molcel.2021.02.022
pmc: PMC8041214
mid: NIHMS1680806
pii:
doi:
Substances chimiques
RNA, Messenger
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1372-1383Subventions
Organisme : NIGMS NIH HHS
ID : R37 GM059425
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007445
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests R.G. is a member of the scientific advisory board at the journal Molecular Cell.
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