Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19.
Adult
Aged
Aged, 80 and over
Biomarkers
/ metabolism
COVID-19
/ immunology
Case-Control Studies
Cytokines
/ metabolism
Dendritic Cells
/ cytology
Female
Gene Expression
/ immunology
Humans
Killer Cells, Natural
/ cytology
Longitudinal Studies
Male
Middle Aged
Severity of Illness Index
Transcriptome
/ immunology
Young Adult
CITE-seq
COVID-19
exhaustion
immune juncture
mixed-effect statistical modeling
single cell multi-omics
time-resolved
Journal
Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066
Informations de publication
Date de publication:
01 04 2021
01 04 2021
Historique:
received:
22
09
2020
revised:
16
12
2020
accepted:
05
02
2021
pubmed:
14
3
2021
medline:
13
4
2021
entrez:
13
3
2021
Statut:
ppublish
Résumé
COVID-19 exhibits extensive patient-to-patient heterogeneity. To link immune response variation to disease severity and outcome over time, we longitudinally assessed circulating proteins as well as 188 surface protein markers, transcriptome, and T cell receptor sequence simultaneously in single peripheral immune cells from COVID-19 patients. Conditional-independence network analysis revealed primary correlates of disease severity, including gene expression signatures of apoptosis in plasmacytoid dendritic cells and attenuated inflammation but increased fatty acid metabolism in CD56
Identifiants
pubmed: 33713619
pii: S0092-8674(21)00168-9
doi: 10.1016/j.cell.2021.02.018
pmc: PMC7874909
pii:
doi:
Substances chimiques
Biomarkers
0
Cytokines
0
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1836-1857.e22Subventions
Organisme : CCR NIH HHS
ID : HHSN261200800001C
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261200800001E
Pays : United States
Investigateurs
Michael S Abers
(MS)
Richard Apps
(R)
Marita Bosticardo
(M)
Pedro Milanez-Almeida
(P)
Matthew P Mulè
(MP)
Elana Shaw
(E)
Yu Zhang
(Y)
Francesco Castelli
(F)
Maria Lorenza Muiesan
(ML)
Gabriele Tomasoni
(G)
Francesco Scolari
(F)
Alessandra Tucci
(A)
Informations de copyright
Copyright © 2021. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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