Neuroprotective schinortriterpenoids from Schisandra neglecta collected in Medog County, Tibet, China.
Animals
Apoptosis
/ drug effects
Cell Survival
/ drug effects
China
Corticosterone
/ antagonists & inhibitors
Crystallography, X-Ray
Dose-Response Relationship, Drug
Models, Molecular
Molecular Structure
Neuroprotective Agents
/ chemistry
PC12 Cells
Rats
Schisandra
/ chemistry
Structure-Activity Relationship
Tibet
Triterpenes
/ chemistry
16,17-secopreschisanartane-type schinortriterpenoids
Neuroprotective activity
Quantum chemical calculation
Schisandra neglecta
Schisdilactones K–U
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
07
01
2021
revised:
23
02
2021
accepted:
24
02
2021
pubmed:
14
3
2021
medline:
13
10
2021
entrez:
13
3
2021
Statut:
ppublish
Résumé
Schisdilactones K-U (1-11), a series of previously unreported 16,17-secopreschisanartane-type schinortriterpenoids (SNTs), were isolated from the leaves and stems of Schisandra neglecta A. C. Smith. Their structures were mainly established through analysis of their spectroscopic data. Besides, schisdilactones K (1), O (5) and R (8) were confirmed by single-crystal X-ray crystallographic analysis, and the configurations of schisdilactones T and U (10 and 11) were elucidated via quantum chemical calculation of their NMR chemical shifts and electronic circular dichroism (ECD) spectra. Schisdilactones L-S (2-8) and U (11) were found to exhibit moderate protective activities against corticosterone-induced apoptosis of PC12 cells at 20 μM, with cell viability in the range of 62.95-66.97%.
Identifiants
pubmed: 33714022
pii: S0045-2068(21)00162-0
doi: 10.1016/j.bioorg.2021.104785
pii:
doi:
Substances chimiques
Neuroprotective Agents
0
Triterpenes
0
Corticosterone
W980KJ009P
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104785Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.