Novel bioactive peptides of Achillea eriophora show anticancer and antioxidant activities.
Achillea
/ chemistry
Antineoplastic Agents, Phytogenic
/ chemistry
Antioxidants
/ chemistry
Biphenyl Compounds
/ antagonists & inhibitors
Cell Proliferation
/ drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Flowers
/ chemistry
Humans
MCF-7 Cells
Molecular Docking Simulation
Molecular Structure
Picrates
/ antagonists & inhibitors
Structure-Activity Relationship
Anticancer
Bioactive peptide
Cupric-ion reducing power
DPPH radical scavenging
LC-MS
RP-HPLC
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
30
09
2020
revised:
19
12
2020
accepted:
21
02
2021
pubmed:
14
3
2021
medline:
13
10
2021
entrez:
13
3
2021
Statut:
ppublish
Résumé
Despite the limitations of current methods in cancer treatment, the use of bioactive peptides can be as an alternative to treat today. Therefore, isolation and relative purification of bioactive peptides was carried out form Achillea eriophora using a Sep-Pak C18 SPE cartridge and Amicon® Ultra Centrifugal Filters. The presence of desired peptides was checked using RP-HPLC and confirmed using LC-MS. The results of anticancer assay showed that the peptide mixture inhibits the growth of MCF-7 cancerous cell line with the values of IC
Identifiants
pubmed: 33714023
pii: S0045-2068(21)00154-1
doi: 10.1016/j.bioorg.2021.104777
pii:
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Antioxidants
0
Biphenyl Compounds
0
Picrates
0
1,1-diphenyl-2-picrylhydrazyl
DFD3H4VGDH
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
104777Informations de copyright
Copyright © 2021. Published by Elsevier Inc.