Extracellular vesicles and their role in gestational diabetes mellitus.
Exosomes
Extracellular vesicles
Gestational diabetes mellitus
Microvesicles
Placenta
Pregnancy
Proteins
miRNAs
Journal
Placenta
ISSN: 1532-3102
Titre abrégé: Placenta
Pays: Netherlands
ID NLM: 8006349
Informations de publication
Date de publication:
15 09 2021
15 09 2021
Historique:
received:
31
10
2020
revised:
19
01
2021
accepted:
18
02
2021
pubmed:
15
3
2021
medline:
19
2
2022
entrez:
14
3
2021
Statut:
ppublish
Résumé
Gestational diabetes mellitus (GDM) is a complex disorder that is defined by glucose intolerance with onset during pregnancy. The incidence of GDM is increasing worldwide. Pregnancies complicated with GDM have higher rates of maternal and fetal morbidity with short- and long-term consequences, including increased rates of cardiovascular disease and type II diabetes for both the mother and offspring. The pathophysiology of GDM still remains unclear and there has been interest in the role of small extracellular vesicles (sEVs) in the maternal metabolic adaptations that occur in pregnancy and GDM. Small EVs are nanosized particles that contain bioactive content, including miRNAs and proteins, which are released by cells to provide cell-to-cell communication. Pregnancy induces an increase in total and placental-secreted sEVs across gestation, with a further increase in sEV number and changes in the protein and miRNA composition of these sEVs in GDM. Research has suggested that these sEVs have an impact on maternal adaptations during pregnancy, including targeting the pancreas, skeletal muscle and adipose tissue. Consequently, this review will focus on the differences in total and placental sEVs in GDM compared to normal pregnancy, the role of sEVs in the pathophysiology of GDM and their clinical application as potential GDM biomarkers.
Identifiants
pubmed: 33714611
pii: S0143-4004(21)00062-X
doi: 10.1016/j.placenta.2021.02.012
pmc: PMC8417136
mid: NIHMS1680778
pii:
doi:
Substances chimiques
MicroRNAs
0
Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
15-22Subventions
Organisme : NICHD NIH HHS
ID : R01 HD089714
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD100015
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
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