Massive intrasplenic arterial thrombosis in a patient with chronic ITP during the development of an Evans syndrome.

Adult Anemia, Hemolytic, Autoimmune / complications Humans Purpura, Thrombocytopenic, Idiopathic / complications Thrombocytopenia / complications Thrombosis / drug therapy
Autoimmune haemolytic anemia Eltrombopag Evans syndrome Immune thrombocytopenia Thrombopoietin receptor agonist Thrombosis

Journal

Thrombosis research
ISSN: 1879-2472
Titre abrégé: Thromb Res
Pays: United States
ID NLM: 0326377

Informations de publication

Date de publication:
12 2021
Historique:
received: 07 02 2020
revised: 29 01 2021
accepted: 16 02 2021
pubmed: 15 3 2021
medline: 24 12 2021
entrez: 14 3 2021
Statut: ppublish

Résumé

Long-term safety and efficacy of eltrombopag in adults with persitent/chronic primary immune thrombocytopenia (ITP) evaluated in EXTEND study, showed a high response rate (80%) but, in the clinical safety study, it was observed that 6% of the patients presented venous and arterial thrombotic events. In addition, in the course of the disease, autoimmune hemolytic anemia (Evans syndrome, ES) may occur and could increase the risk of thrombosis. We report an interesting case of splenic rupture due to massive intrasplenic arterial thrombosis in the course of ES in a patient with chronic ITP treated with eltrombopag. The purpose of this case report is to highlight the potential increase in thrombotic risk that may involve the use of eltrombopag in hemolysis situations in patients with ITP.

Identifiants

DOI: 10.1016/j.thromres.2021.02.021 PMID: 33714615
pubmed: 33714615
pii: S0049-3848(21)00076-1
doi: 10.1016/j.thromres.2021.02.021
pii:
doi:

Types de publication

Case Reports Editorial

Langues

eng

Sous-ensembles de citation

IM

Pagination

226-229

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

R Diez-Feijóo (R)

Department of Hematology, Hospital del Mar, Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.

J J Rodríguez-Sevilla (JJ)

Department of Hematology, Hospital del Mar, Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain. Electronic address: 63639@parcdesalutmar.cat.

L Colomo (L)

Department of Pathology, Hospital del Mar, Barcelona, Spain.

N Papaleo (N)

Department of Pathology, Hospital del Mar, Barcelona, Spain.

J M Maiques (JM)

Department of Radiology, Hospital del Mar, Barcelona, Spain.

E Gimeno (E)

Department of Hematology, Hospital del Mar, Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.

M Andrade-Campos (M)

Department of Hematology, Hospital del Mar, Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.

E Abella (E)

Department of Hematology, Hospital del Mar, Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.

B M Merchan (BM)

Department of Hematology, Hospital del Mar, Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.

X Calvo (X)

Department of Pathology, Hospital del Mar, Barcelona, Spain.

C Jimenez (C)

Department of Hematology, Hospital del Mar, Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.

O D Román-Bravo (OD)

Department of Hematology, Hospital del Mar, Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.

A Salar (A)

Department of Hematology, Hospital del Mar, Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.

B Sanchez-Gonzalez (B)

Department of Hematology, Hospital del Mar, Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Massive intrasplenic arterial thrombosis in a...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Anémie hémolytique auto-immune › Massive intrasplenic arterial thrombosis in a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Massive intrasplenic arterial thrombosis in a...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations cutanées › Purpura › Purpura thrombopénique › Purpura thrombopénique idiopathique › Massive intrasplenic arterial thrombosis in a...
questionsmedicales.fr › Hémopathies et maladies lymphatiques › Hémopathies › Anomalies des plaquettes › Thrombopénie › Massive intrasplenic arterial thrombosis in a...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Embolie et thrombose › Thrombose › Massive intrasplenic arterial thrombosis in a...