pH-responsive polymersome-mediated delivery of doxorubicin into tumor sites enhances the therapeutic efficacy and reduces cardiotoxic effects.
Antitumor activity
Cardiotoxicity
Doxorubicin
Nanomedicine
pH-responsive polymersomes
Journal
Journal of controlled release : official journal of the Controlled Release Society
ISSN: 1873-4995
Titre abrégé: J Control Release
Pays: Netherlands
ID NLM: 8607908
Informations de publication
Date de publication:
10 04 2021
10 04 2021
Historique:
received:
22
10
2020
revised:
11
02
2021
accepted:
09
03
2021
pubmed:
16
3
2021
medline:
8
7
2021
entrez:
15
3
2021
Statut:
ppublish
Résumé
The delivery of therapeutics into sites of action by using cargo-delivery platforms potentially minimizes their premature degradation and fast clearance from the bloodstream. Additionally, drug-loaded stimuli-responsive supramolecular assemblies can be produced to respond to the inherent features of tumor microenvironments, such as extracellular acidosis. We report in this framework the use of pH-responsive polymersomes (PSs) manufactured using poly([N-(2-hydroxypropyl)] methacrylamide)
Identifiants
pubmed: 33716094
pii: S0168-3659(21)00124-3
doi: 10.1016/j.jconrel.2021.03.013
pii:
doi:
Substances chimiques
Drug Carriers
0
Doxorubicin
80168379AG
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
529-538Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.