Risk-Benefit Modeling to Guide Health Research in Collaboration with Great Lakes Fish Consuming Native American Communities.

It is well documented that fish consumption imparts both health risks and benefits. Furthermore, fish harvest and consumption are an essential part of Great Lakes Native American cultures. Quantitative models that compare risk and benefits to potential consumption scenarios can help guide future health research as well as consumption advice for potentially sensitive populations. This article presents fish consumption scenarios based on self-reported meal plans constructed by tribal members in eastern upper peninsula and northern lower Michigan Anishinaabe. Two risk-benefit models were applied to these scenarios to estimate the potential neurodevelopmental and cardiovascular risks (either increased or reduced risk) from dioxin-like polychlorinated biphenyls (DL-PCBs), methylmercury (MeHg), and omega-3 polyunsaturated fatty acids (n3-PUFA). All scenarios except maximum exposure estimates (i.e. 25