A Giant Mammary Hamartoma in a Young Breast Cancer Patient.
Breast cancer
Hamartoma of the breast
PTEN mutation
Journal
Breast care (Basel, Switzerland)
ISSN: 1661-3791
Titre abrégé: Breast Care (Basel)
Pays: Switzerland
ID NLM: 101254060
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
17
02
2020
accepted:
31
03
2020
entrez:
15
3
2021
pubmed:
16
3
2021
medline:
16
3
2021
Statut:
ppublish
Résumé
Hamartomas of the breast are rare benign tumors. Pre- and also postoperative differentiation from other benign or even malignant tumors is challenging. A 36-year-old female presented with a giant tumor of the left breast. The patient had suffered from an early breast cancer of the contralateral right breast the year before, which was treated with breast-conserving therapy, radiation, and endocrine therapy ever since. The hamartoma was classified as BI-RADS 2 in mammography and BI-RADS 4 in ultrasound. On clinical examination, a tumor of nearly 15 cm in size led to an abstruse deformity of the breast and the nipple-areola complex. We found an indolent, grand bulging tumor with an elastic texture directly beneath the skin. A biopsy that had been performed before was compatible with the suspected hamartoma. Because of the remaining diagnostic uncertainties after contralateral breast cancer and the progressive malformation of the left breast, a tumor extirpation utilizing a reduction mammaplasty was performed without complications. Subsequent genetic analyses excluded a loss of PTEN in this patient. We presented the rare case of a 36-year-old woman with a history of breast cancer and a 700-g breast hamartoma. The preoperative and even the postoperative specification of a hamartoma remains challenging, and associations with genetic alterations should be considered.
Sections du résumé
BACKGROUND
BACKGROUND
Hamartomas of the breast are rare benign tumors. Pre- and also postoperative differentiation from other benign or even malignant tumors is challenging.
CASE PRESENTATION
METHODS
A 36-year-old female presented with a giant tumor of the left breast. The patient had suffered from an early breast cancer of the contralateral right breast the year before, which was treated with breast-conserving therapy, radiation, and endocrine therapy ever since. The hamartoma was classified as BI-RADS 2 in mammography and BI-RADS 4 in ultrasound. On clinical examination, a tumor of nearly 15 cm in size led to an abstruse deformity of the breast and the nipple-areola complex. We found an indolent, grand bulging tumor with an elastic texture directly beneath the skin. A biopsy that had been performed before was compatible with the suspected hamartoma. Because of the remaining diagnostic uncertainties after contralateral breast cancer and the progressive malformation of the left breast, a tumor extirpation utilizing a reduction mammaplasty was performed without complications. Subsequent genetic analyses excluded a loss of PTEN in this patient.
CONCLUSION
CONCLUSIONS
We presented the rare case of a 36-year-old woman with a history of breast cancer and a 700-g breast hamartoma. The preoperative and even the postoperative specification of a hamartoma remains challenging, and associations with genetic alterations should be considered.
Identifiants
pubmed: 33716636
doi: 10.1159/000507604
pii: brc-0016-0085
pmc: PMC7923926
doi:
Types de publication
Case Reports
Langues
eng
Pagination
85-88Informations de copyright
Copyright © 2020 by S. Karger AG, Basel.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to declare.
Références
Arch Pathol Lab Med. 2016 Jul;140(7):665-71
pubmed: 27362571
Breast Care (Basel). 2018 Dec;13(6):403-412
pubmed: 30800034
Histopathology. 2002 Jul;41(1):30-4
pubmed: 12121234
J Clin Pathol. 2002 Jul;55(7):541-2
pubmed: 12101205
Clinics (Sao Paulo). 2014 Aug;69(8):515-23
pubmed: 25141109
J Med Genet. 2013 Apr;50(4):255-63
pubmed: 23335809
Appl Pathol. 1989;7(2):145-8
pubmed: 2730800
Adolesc Med Clin. 2004 Oct;15(3):473-85
pubmed: 15625988
Histopathology. 1992 Feb;20(2):99-106
pubmed: 1559675
Pathol Res Pract. 1994 Apr;190(4):362-71
pubmed: 8078805
Breast Cancer Res Treat. 2017 Aug;165(1):1-8
pubmed: 26700035
J Ultrasound. 2015 Jul 26;18(4):373-7
pubmed: 26550075
Semin Diagn Pathol. 2017 Sep;34(5):438-452
pubmed: 28688536