Baseline Arterial CO
PaCO2
acute intermittent hypoxia
phrenic activity
phrenic long-term facilitation
respiratory plasticity
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2021
2021
Historique:
received:
16
06
2020
accepted:
02
02
2021
entrez:
15
3
2021
pubmed:
16
3
2021
medline:
16
3
2021
Statut:
epublish
Résumé
Moderate acute intermittent hypoxia (mAIH) elicits a progressive increase in phrenic motor output lasting hours post-mAIH, a form of respiratory motor plasticity known as phrenic long-term facilitation (pLTF). mAIH-induced pLTF is initiated by activation of spinally-projecting raphe serotonergic neurons during hypoxia and subsequent serotonin release near phrenic motor neurons. Since raphe serotonergic neurons are also sensitive to pH and CO
Identifiants
pubmed: 33716760
doi: 10.3389/fphys.2021.573385
pmc: PMC7943620
doi:
Types de publication
Journal Article
Langues
eng
Pagination
573385Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL148030
Pays : United States
Informations de copyright
Copyright © 2021 Perim, El-Chami, Gonzalez-Rothi and Mitchell.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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