The Roles of Immunoregulatory Networks in Severe Drug Hypersensitivity.
Animals
Biomarkers
Costimulatory and Inhibitory T-Cell Receptors
/ metabolism
Cytokines
/ metabolism
Diagnosis, Differential
Disease Susceptibility
/ immunology
Drug Hypersensitivity
/ diagnosis
Gene Expression Regulation
Humans
Immunomodulation
Severity of Illness Index
Signal Transduction
T-Lymphocyte Subsets
/ immunology
Stevens-Johnson Syndrome
contact dermatitis
cosignaling pathways
delayed type hypersensitivity
drug reaction with eosinophilia and systemic symptoms
immune checkpoints
regulatory T cells
toxic epidermal necrolysis
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
21
08
2020
accepted:
18
01
2021
entrez:
15
3
2021
pubmed:
16
3
2021
medline:
3
7
2021
Statut:
epublish
Résumé
The immunomodulatory effects of regulatory T cells (Tregs) and co-signaling receptors have gained much attention, as they help balance immunogenic and immunotolerant responses that may be disrupted in autoimmune and infectious diseases. Drug hypersensitivity has a myriad of manifestations, which ranges from the mild maculopapular exanthema to the severe Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms/drug-induced hypersensitivity syndrome (DRESS/DIHS). While studies have identified high-risk human leukocyte antigen (HLA) allotypes, the presence of the HLA allotype at risk is not sufficient to elicit drug hypersensitivity. Recent studies have suggested that insufficient regulation by Tregs may play a role in severe hypersensitivity reactions. Furthermore, immune checkpoint inhibitors, such as anti-CTLA-4 or anti-PD-1, in cancer treatment also induce hypersensitivity reactions including SJS/TEN and DRESS/DIHS. Taken together, mechanisms involving both Tregs as well as coinhibitory and costimulatory receptors may be crucial in the pathogenesis of drug hypersensitivity. In this review, we summarize the currently implicated roles of co-signaling receptors and Tregs in delayed-type drug hypersensitivity in the hope of identifying potential pharmacologic targets.
Identifiants
pubmed: 33717075
doi: 10.3389/fimmu.2021.597761
pmc: PMC7953830
doi:
Substances chimiques
Biomarkers
0
Costimulatory and Inhibitory T-Cell Receptors
0
Cytokines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
597761Informations de copyright
Copyright © 2021 Hsu, Lu, Fu, Wang, Lu, Lin, Chang, Yeh, Hung, Chung and Chen.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Acta Pharm Sin B. 2020 Mar;10(3):414-433
pubmed: 32140389
J Immunol Res. 2017;2017:3186328
pubmed: 29333460
Trends Immunol. 2016 Jul;37(7):427-439
pubmed: 27236363
J Am Acad Dermatol. 2014 Jun;70(6):1096-102
pubmed: 24629995
J Cutan Pathol. 2017 Apr;44(4):381-384
pubmed: 28000240
J Exp Med. 2003 Aug 18;198(4):557-67
pubmed: 12913096
J Allergy Clin Immunol. 2010 Mar;125(3):703-10, 710.e1-710.e8
pubmed: 20132973
Nat Rev Immunol. 2008 Jul;8(7):523-32
pubmed: 18566595
Clin Exp Dermatol. 1997 May;22(3):118-23
pubmed: 9425690
J Immunol. 2016 Feb 1;196(3):1108-22
pubmed: 26712945
Curr Opin Immunol. 2015 Apr;33:23-35
pubmed: 25621841
Front Oncol. 2020 Aug 07;10:1595
pubmed: 32903786
J Immunol. 2003 Dec 1;171(11):5760-8
pubmed: 14634084
Drug Saf. 2019 Aug;42(8):973-992
pubmed: 31020549
Front Immunol. 2018 Oct 08;9:2306
pubmed: 30349540
Int J Mol Sci. 2018 Mar 03;19(3):
pubmed: 29510522
Immunity. 2016 May 17;44(5):973-88
pubmed: 27192564
Adv Immunol. 2010;105:63-98
pubmed: 20510730
J Clin Invest. 2018 Jul 2;128(7):2746-2749
pubmed: 29781810
Nat Rev Immunol. 2011 Nov 25;11(12):852-63
pubmed: 22116087
Immunity. 2017 Apr 18;46(4):660-674
pubmed: 28423340
J Dermatol Sci. 2020 Apr;98(1):2-12
pubmed: 32192826
N Engl J Med. 2013 Oct 24;369(17):1620-8
pubmed: 24152261
Am J Clin Dermatol. 2000 Nov-Dec;1(6):349-60
pubmed: 11702611
Chem Res Toxicol. 2015 Dec 21;28(12):2287-91
pubmed: 26529122
Ann Allergy Asthma Immunol. 2016 Nov;117(5):514-519
pubmed: 27788881
J Immunol. 2015 Jun 15;194(12):5801-11
pubmed: 25934860
Clin Exp Immunol. 2017 Oct;190(1):1-7
pubmed: 28600865
Immune Netw. 2020 Feb 07;20(1):e3
pubmed: 32158591
J Immunol. 2009 Mar 1;182(5):2708-16
pubmed: 19234165
Eur J Immunol. 2005 Jun;35(6):1722-30
pubmed: 15909306
Eur J Immunol. 2004 Dec;34(12):3456-64
pubmed: 15517612
Immunity. 2016 May 17;44(5):955-72
pubmed: 27192563
J Allergy Clin Immunol Pract. 2018 Jan - Feb;6(1):38-69
pubmed: 29310768
Cytokine Growth Factor Rev. 2014 Apr;25(2):91-106
pubmed: 24484736
J Allergy Clin Immunol. 2015 Aug;136(2):219-34; quiz 235
pubmed: 26254049
Nat Immunol. 2010 Jan;11(1):7-13
pubmed: 20016504
Cell Mol Immunol. 2011 Jul;8(4):281-4
pubmed: 21217771
J Immunol. 2008 Dec 15;181(12):8391-401
pubmed: 19050256
Ann Rheum Dis. 2019 Feb;78(2):209-217
pubmed: 30472651
Dis Markers. 2019 Jan 10;2019:5160565
pubmed: 30733837
Front Immunol. 2019 Apr 24;10:881
pubmed: 31068947
Cancer Res. 2017 Mar 1;77(5):1108-1118
pubmed: 28122327
J Allergy Clin Immunol. 2019 Jun;143(6):2147-2157.e9
pubmed: 30654051
J Control Release. 2017 Sep 10;261:223-233
pubmed: 28694031
J Clin Invest. 1997 Mar 1;99(5):937-43
pubmed: 9062351
J Leukoc Biol. 2005 Sep;78(3):725-35
pubmed: 16000396
Annu Rev Immunol. 2008;26:677-704
pubmed: 18173375
Front Immunol. 2015 Aug 21;6:418
pubmed: 26347741
N Engl J Med. 2008 Feb 7;358(6):568-79
pubmed: 18256392
Annu Rev Immunol. 2020 Apr 26;38:541-566
pubmed: 32017635
J Allergy Clin Immunol. 2006 Feb;117(2):455-62
pubmed: 16461148
JAMA Dermatol. 2017 Jun 1;153(6):514-522
pubmed: 28329382
Br J Dermatol. 2006 Oct;155(4):722-8
pubmed: 16965421
J Allergy Clin Immunol. 2010 Aug;126(2):280-9, 289.e1-7
pubmed: 20624644
Nat Immunol. 2019 Nov;20(11):1425-1434
pubmed: 31611702
J Immunol. 2014 Mar 15;192(6):2611-2621
pubmed: 24510967
Nature. 2001 Mar 29;410(6828):608-11
pubmed: 11279502
Front Immunol. 2012 Jun 22;3:165
pubmed: 22737152
Br J Dermatol. 2012 Feb;166(2):322-30
pubmed: 21936856
Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9721-6
pubmed: 18607004
J Allergy Clin Immunol. 2012 Jun;129(6):1562-9.e5
pubmed: 22322005
Nat Immunol. 2019 Feb;20(2):218-231
pubmed: 30643268
Br J Dermatol. 2008 Sep;159(3):546-54
pubmed: 18616786
Int Immunopharmacol. 2020 Mar;80:106221
pubmed: 32007707
J Immunol. 2015 Jul 1;195(1):145-55
pubmed: 25994968
Clin Cancer Res. 2016 Aug 15;22(16):4023-9
pubmed: 26957557
Immunity. 2004 Oct;21(4):503-13
pubmed: 15485628
Front Oncol. 2015 Jun 08;5:117
pubmed: 26106583
Blood. 2007 Jan 1;109(1):194-202
pubmed: 16968902
J Invest Dermatol. 2017 Jan;137(1):106-114
pubmed: 27623510
Cell Mol Life Sci. 2001 Jan;58(1):4-43
pubmed: 11229815
J Autoimmun. 2019 Mar;98:86-94
pubmed: 30616979
Sci Rep. 2016 Oct 19;6:35002
pubmed: 27756896
Asia Pac Allergy. 2019 Jan 28;9(1):e9
pubmed: 30740357
Hepatology. 2015 Apr;61(4):1332-42
pubmed: 25283142
Eur J Immunol. 2002 Nov;32(11):3326-35
pubmed: 12555678
J Immunol. 2001 Feb 15;166(4):2323-32
pubmed: 11160289
Am J Clin Dermatol. 2015 Dec;16(6):475-93
pubmed: 26481651
Nat Immunol. 2003 Apr;4(4):330-6
pubmed: 12612578
Nat Immunol. 2009 Jan;10(1):48-57
pubmed: 19011627
Arthritis Res Ther. 2015 Feb 23;17:35
pubmed: 25890083
Nat Med. 2008 Dec;14(12):1343-50
pubmed: 19029983
Nat Immunol. 2010 Sep;11(9):846-53
pubmed: 20676092
J Biol Chem. 2005 Nov 11;280(45):37725-31
pubmed: 16155000
Ann Intern Med. 2009 Oct 6;151(7):514-5
pubmed: 19805776
Epilepsy Res. 2011 Nov;97(1-2):190-7
pubmed: 21917426
J Invest Dermatol. 2018 Mar;138(3):570-579
pubmed: 29045819
J Immunol. 2009 Aug 15;183(4):2827-36
pubmed: 19635903
JCI Insight. 2018 Jul 26;3(14):
pubmed: 30046006
J Exp Med. 1995 Jul 1;182(1):99-108
pubmed: 7790826
Rheumatology (Oxford). 2018 Dec 1;57(12):2244-2246
pubmed: 30107548
Oncoimmunology. 2015 Nov 11;5(4):e1113367
pubmed: 27141396
Curr Opin Immunol. 2019 Oct;60:54-62
pubmed: 31163387
Eur J Dermatol. 2009 Jul-Aug;19(4):325-32
pubmed: 19447733
Immunity. 2016 May 17;44(5):1052-68
pubmed: 27192569
Immunity. 2014 Jun 19;40(6):989-1001
pubmed: 24909886
J Immunol. 2013 May 1;190(9):4483-7
pubmed: 23543753
Nat Rev Rheumatol. 2019 Jan;15(1):2
pubmed: 30518787
Chem Res Toxicol. 2017 Jan 17;30(1):295-314
pubmed: 27775332
Cancer Discov. 2018 Sep;8(9):1069-1086
pubmed: 30115704
Br J Dermatol. 2013 Nov;169(5):1071-80
pubmed: 23855313
Exp Dermatol. 2017 May;26(5):449-451
pubmed: 27714845
J Dermatol Sci. 2016 Feb;81(2):131-4
pubmed: 26596217
Arch Dermatol. 1993 Aug;129(8):1059
pubmed: 8352614
Science. 2008 Oct 10;322(5899):271-5
pubmed: 18845758
Immunity. 2008 Jun;28(6):870-80
pubmed: 18513999
Nat Immunol. 2003 Jul;4(7):670-9
pubmed: 12796776
J Dermatol Sci. 2014 Jan;73(1):85-8
pubmed: 24035443
Cell. 2008 May 30;133(5):775-87
pubmed: 18510923
Allergy Asthma Proc. 2012 May-Jun;33 Suppl 1:96-99
pubmed: 22794701
Immunology. 2017 Nov;152(3):372-381
pubmed: 28699278
N Engl J Med. 1994 Nov 10;331(19):1272-85
pubmed: 7794310
Arch Dermatol. 1993 Jan;129(1):92-6
pubmed: 8420497
Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17858-63
pubmed: 19815499
Science. 2000 Apr 28;288(5466):675-8
pubmed: 10784451
Front Immunol. 2019 Aug 27;10:2022
pubmed: 31507611
Melanoma Res. 2013 Dec;23(6):498-501
pubmed: 24113862
J Allergy Clin Immunol Pract. 2019 Jan;7(1):325-327
pubmed: 29936189
Eur J Cancer. 2016 Nov;67:1-10
pubmed: 27591414
Am J Clin Dermatol. 2018 Jun;19(3):345-361
pubmed: 29256113
Proc Natl Acad Sci U S A. 1991 Jul 1;88(13):5528-32
pubmed: 2062835
Nat Immunol. 2018 Dec;19(12):1415-1426
pubmed: 30349037
J Clin Invest. 2012 May;122(5):1700-11
pubmed: 22523067
J Med Genet. 2002 Aug;39(8):537-45
pubmed: 12161590
Am Fam Physician. 2010 Aug 1;82(3):249-55
pubmed: 20672788
Br J Dermatol. 2006 Feb;154(2):319-24
pubmed: 16433803
Blood. 2018 Jan 4;131(1):58-67
pubmed: 29118008
Cancers Head Neck. 2016 Oct 1;1:12
pubmed: 31093342
J Immunol. 2017 Aug 15;199(4):1223-1237
pubmed: 28687658
J Immunol. 2007 Nov 1;179(9):5916-26
pubmed: 17947665
Clin Exp Allergy. 2020 May;50(5):640-642
pubmed: 32056306
Am J Pathol. 1993 Jul;143(1):3-9
pubmed: 8317552
Cancer Immunol Res. 2018 Oct;6(10):1199-1211
pubmed: 30154083
J Immunol. 2007 May 1;178(9):5533-42
pubmed: 17442935
Eur J Immunol. 2010 Sep;40(9):2528-38
pubmed: 20690182
Eur J Immunol. 2006 Nov;36(11):2981-92
pubmed: 17048272
Nat Rev Immunol. 2017 Nov;17(11):703-717
pubmed: 28757603
Allergol Int. 2019 Jul;68(3):301-308
pubmed: 31000444
Immunity. 2002 Aug;17(2):201-10
pubmed: 12196291
Jpn J Infect Dis. 2017 Jul 24;70(4):430-436
pubmed: 28250252
J Immunol. 1997 Apr 15;158(8):3603-9
pubmed: 9103421
Int J Dermatol. 2020 Jun;59(6):e183-e188
pubmed: 32052409
J Clin Invest. 2018 Jul 2;128(7):2819-2832
pubmed: 29782330
J Exp Med. 2000 Jun 5;191(11):2011-20
pubmed: 10839815
J Immunol. 2004 May 15;172(10):5931-9
pubmed: 15128774
Drugs. 2017 Jul;77(11):1221-1233
pubmed: 28608166
Acta Derm Venereol. 2020 Mar 31;100(6):adv00102
pubmed: 32201900
Am J Med. 2011 Jul;124(7):588-97
pubmed: 21592453
J Clin Invest. 2013 Feb;123(2):580-93
pubmed: 23281398
Nat Immunol. 2012 Feb 05;13(3):290-9
pubmed: 22306691
JAAD Case Rep. 2019 Feb 12;5(3):216-218
pubmed: 30809563
J Clin Virol. 2006 Dec;37 Suppl 1:S92-6
pubmed: 17276377
Annu Rev Immunol. 1996;14:233-58
pubmed: 8717514
J Immunol. 1998 Jun 15;160(12):5742-8
pubmed: 9637483
Clin Exp Allergy. 2007 Jul;37(7):989-99
pubmed: 17581192
Exp Dermatol. 2016 Mar;25(3):233-4
pubmed: 26513536
J Allergy Clin Immunol. 2011 Mar;127(3 Suppl):S60-6
pubmed: 21354501
J Dermatol Sci. 2016 Aug;83(2):151-4
pubmed: 27174092
Immunobiology. 2020 Jan;225(1):151868
pubmed: 31784043
Front Immunol. 2017 Nov 24;8:1578
pubmed: 29225597
Nat Rev Immunol. 2020 Nov;20(11):680-693
pubmed: 32269380
N Engl J Med. 2011 Mar 24;364(12):1126-33
pubmed: 21428768
Nat Commun. 2019 Aug 8;10(1):3569
pubmed: 31395875
N Engl J Med. 2018 Jan 11;378(2):158-168
pubmed: 29320654
Sci Transl Med. 2019 Jun 12;11(496):
pubmed: 31189721
Immunol Rev. 2010 Jul;236:219-42
pubmed: 20636820
Cells. 2019 Oct 08;8(10):
pubmed: 31597242
Nat Immunol. 2002 Feb;3(2):135-42
pubmed: 11812990
Allergy. 2019 Sep;74(9):1769-1779
pubmed: 31034608
Int Immunol. 2004 Apr;16(4):533-8
pubmed: 15039383
Mol Immunol. 2017 Mar;83:13-22
pubmed: 28092803
J Immunol. 2008 May 1;180(9):5916-26
pubmed: 18424711
J Leukoc Biol. 2011 Jan;89(1):21-9
pubmed: 20643812
Acta Derm Venereol. 2014 Jan;94(1):86-7
pubmed: 23722430
Nature. 1987 Jul 16-22;328(6127):267-70
pubmed: 3496540
Nat Immunol. 2007 Dec;8(12):1353-62
pubmed: 17982458
J Clin Invest. 2018 Mar 1;128(3):985-996
pubmed: 29400697
Clin Exp Immunol. 2011 May;164(2):265-74
pubmed: 21352204
Front Immunol. 2018 Oct 17;9:2374
pubmed: 30386337
Genes Cancer. 2018 May;9(5-6):176-189
pubmed: 30603054
J Immunol. 2014 Dec 1;193(11):5525-33
pubmed: 25348623
J Clin Invest. 2010 Mar;120(3):883-93
pubmed: 20179354
Clin Chem. 2007 Sep;53(9):1700-5
pubmed: 17712006
J Invest Dermatol. 2017 May;137(5):1065-1073
pubmed: 28011147
Pharmacotherapy. 2007 Oct;27(10):1425-39
pubmed: 17896897
J Invest Dermatol. 2008 Aug;128(8):2119-22
pubmed: 18256693
Clin Immunol. 2019 Oct;207:49-54
pubmed: 31325629
J Immunol. 2005 Feb 15;174(4):1783-6
pubmed: 15699103
J Allergy Clin Immunol. 2002 Jan;109(1):155-61
pubmed: 11799383
J Immunol. 2015 Nov 1;195(9):4154-61
pubmed: 26408668
Immunity. 1999 Dec;11(6):689-98
pubmed: 10626891
J Clin Pharmacol. 2018 Jan;58(1):107-113
pubmed: 28750137
J Invest Dermatol. 2013 Mar;133(3):702-711
pubmed: 23190882
Front Oncol. 2018 Mar 28;8:86
pubmed: 29644214
J Exp Med. 2003 Dec 15;198(12):1875-86
pubmed: 14676299
Eur J Immunol. 1997 Dec;27(12):3143-50
pubmed: 9464799
JCI Insight. 2018 Jul 12;3(13):
pubmed: 29997289
J Exp Med. 2005 Apr 4;201(7):1061-7
pubmed: 15809351
Sci Immunol. 2018 Dec 21;3(30):
pubmed: 30578350
Immunotargets Ther. 2015 May 28;4:111-22
pubmed: 27471717
J Immunol. 2009 Jun 15;182(12):8071-9
pubmed: 19494333
Rheumatology (Oxford). 2017 Jun 1;56(6):861-862
pubmed: 27402872
Nat Immunol. 2016 Nov;17(11):1322-1333
pubmed: 27595233
J Immunol. 1996 Dec 1;157(11):4822-9
pubmed: 8943384
J Immunol. 2013 Oct 1;191(7):3673-80
pubmed: 23980210
J Dermatol. 2012 Sep;39(9):781-6
pubmed: 22458564
Curr Opin Allergy Clin Immunol. 2008 Aug;8(4):299-307
pubmed: 18596585
Genes Immun. 2014 Dec;15(8):511-20
pubmed: 25056447
J Immunol. 2015 Jun 15;194(12):5644-53
pubmed: 25972481
Annu Rev Immunol. 2020 Apr 26;38:421-453
pubmed: 31990619
Nat Immunol. 2005 Jan;6(1):90-8
pubmed: 15568026
Clin Exp Immunol. 2013 Feb;171(2):220-30
pubmed: 23286949
Nat Immunol. 2005 Nov;6(11):1142-51
pubmed: 16227984
Int J Med Sci. 2018 Apr 3;15(7):666-673
pubmed: 29910670
Cold Spring Harb Perspect Biol. 2018 Mar 1;10(3):
pubmed: 28620098
Eur J Cancer. 2020 May;131:1-4
pubmed: 32248069
J Immunol Res. 2018 Feb 13;2018:6431694
pubmed: 29651444
Expert Opin Drug Metab Toxicol. 2017 Jul;13(7):701-704
pubmed: 28633581
J Allergy Clin Immunol. 2012 Aug;130(2):444-52.e7
pubmed: 22738679
J Allergy Clin Immunol Pract. 2019 Nov - Dec;7(8):2739-2749.e3
pubmed: 31201937
Clin Exp Allergy. 2018 Nov;48(11):1453-1463
pubmed: 30112775
Allergy. 2020 Apr;75(4):781-797
pubmed: 31758810
J Clin Oncol. 2019 Oct 20;37(30):2746-2758
pubmed: 31216228
Science. 2011 Apr 29;332(6029):600-3
pubmed: 21474713
Clin Exp Dermatol. 2014 Apr;39(3):284-91
pubmed: 24635062
J Autoimmun. 2019 Nov;104:102333
pubmed: 31564474
Front Immunol. 2019 Oct 02;10:2216
pubmed: 31632390
Annu Rev Immunol. 2004;22:531-62
pubmed: 15032588
Clin Rev Allergy Immunol. 2007 Oct;33(1-2):124-33
pubmed: 18094951
J Am Acad Dermatol. 2019 Mar;80(3):670-678.e2
pubmed: 30240780
J Allergy Clin Immunol. 2009 Jun;123(6):1287-96.e2
pubmed: 19427686
Trends Immunol. 2016 Nov;37(11):803-811
pubmed: 27623114
Nat Rev Immunol. 2018 Mar;18(3):153-167
pubmed: 28990585
J Immunol. 2014 Apr 1;192(7):2984-93
pubmed: 24591375
J Microbiol Immunol Infect. 2008 Dec;41(6):462-8
pubmed: 19255689
Nature. 2004 Apr 1;428(6982):486
pubmed: 15057820
J Immunol. 2016 Sep 1;197(5):1567-76
pubmed: 27439515
J Immunol Res. 2016;2016:1720827
pubmed: 27298831