MCPIP-1 Restricts Inflammation via Promoting Apoptosis of Neutrophils.
GM-CSF
MCPIP-1
apoptosis
inflammation
miRNA
neutrophils
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
10
11
2020
accepted:
08
02
2021
entrez:
15
3
2021
pubmed:
16
3
2021
medline:
5
10
2021
Statut:
epublish
Résumé
Monocyte chemoattractant protein-induced protein-1 (MCPIP-1) is a potent inhibitor of inflammatory response to pathogens. Acting as endonuclease against transcripts of inflammatory cytokines or transcription factors MCPIP-1 can significantly reduce the cytokine storm, thus limiting the tissue damage. As the adequate resolution of inflammation depends also on the efficient clearance of accumulated neutrophils, we focused on the role of MCPIP-1 in apoptosis and retention of neutrophils. We used peritoneal neutrophils from cell-specific MCPIP-1 knockout mice and showed prolonged survival of these cells. Moreover, we confirmed that MCPIP-1-dependent degradation of transcripts of antiapoptotic genes, including
Identifiants
pubmed: 33717148
doi: 10.3389/fimmu.2021.627922
pmc: PMC7952515
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Apoptosis Regulatory Proteins
0
MicroRNAs
0
Transcription Factors
0
Ribonucleases
EC 3.1.-
ZC3H12A protein, human
EC 3.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
627922Informations de copyright
Copyright © 2021 Dobosz, Wadowska, Kaminska, Wilamowski, Honarpisheh, Bryzek, Potempa, Jura, Lech and Koziel.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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