Early MRI outcomes in participants with a first clinical demyelinating event at risk of multiple sclerosis in the ORACLE-MS study.

First clinical demyelinating event ORACLE-MS cladribine tablets lesions magnetic resonance imaging multiple sclerosis

Journal

Multiple sclerosis journal - experimental, translational and clinical
ISSN: 2055-2173
Titre abrégé: Mult Scler J Exp Transl Clin
Pays: United States
ID NLM: 101668877

Informations de publication

Date de publication:
Historique:
received: 28 09 2020
accepted: 09 01 2021
entrez: 15 3 2021
pubmed: 16 3 2021
medline: 16 3 2021
Statut: epublish

Résumé

In the Phase 3, 96-week ORACLE-MS study, cladribine tablets 10 mg (3.5 or 5.25 mg/kg cumulative dosage over two years) significantly reduced lesions associated with multiple sclerosis versus placebo in participants following a first clinical demyelinating event (FCDE). To determine the timing of effects of cladribine tablets on lesion activity assessed by magnetic resonance imaging (MRI). This Compared to placebo, cladribine tablets 3.5 mg/kg treatment appeared to lead to a trend of reductions in the mean number of T1 Gd+ lesions by Week 13 (first post-baseline scan: 0.37 vs. 1.00), new or enlarging T2 (0.20 vs. 1.01) and combined unique active (0.29 vs. 1.91) lesions by Week 24. Low lesion counts were maintained with cladribine tablets throughout 96 weeks. Similar results were observed with the 5.25 mg/kg dosage. In participants with an FCDE, cladribine tablets appeared to reduce lesion numbers within 13 weeks (time of first evaluation).

Sections du résumé

BACKGROUND BACKGROUND
In the Phase 3, 96-week ORACLE-MS study, cladribine tablets 10 mg (3.5 or 5.25 mg/kg cumulative dosage over two years) significantly reduced lesions associated with multiple sclerosis versus placebo in participants following a first clinical demyelinating event (FCDE).
OBJECTIVE OBJECTIVE
To determine the timing of effects of cladribine tablets on lesion activity assessed by magnetic resonance imaging (MRI).
METHODS METHODS
This
RESULTS RESULTS
Compared to placebo, cladribine tablets 3.5 mg/kg treatment appeared to lead to a trend of reductions in the mean number of T1 Gd+ lesions by Week 13 (first post-baseline scan: 0.37 vs. 1.00), new or enlarging T2 (0.20 vs. 1.01) and combined unique active (0.29 vs. 1.91) lesions by Week 24. Low lesion counts were maintained with cladribine tablets throughout 96 weeks. Similar results were observed with the 5.25 mg/kg dosage.
CONCLUSION CONCLUSIONS
In participants with an FCDE, cladribine tablets appeared to reduce lesion numbers within 13 weeks (time of first evaluation).

Identifiants

pubmed: 33717501
doi: 10.1177/2055217321990852
pii: 10.1177_2055217321990852
pmc: PMC7925953
doi:

Types de publication

Journal Article

Langues

eng

Pagination

2055217321990852

Informations de copyright

© The Author(s) 2021.

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Auteurs

Mark S Freedman (MS)

Department of Medicine and the Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada.

Patricia K Coyle (PK)

Department of Neurology, Stony Brook University, Stony Brook, NY, USA.

Giancarlo Comi (G)

Institute of Experimental Neurology, IRCCS Ospedale San Raffaele, Milan, Italy.

Susan L Scarberry (S)

Sanford Health Multiple Sclerosis Center, Fargo, ND, USA.

Doris Damian (D)

EMD Serono Research & Development Institute, Inc, Billerica, MA, USA, an affiliate of Merck KGaA, Darmstadt, Germany.

Yann Hyvert (Y)

Merck KGaA, Darmstadt, Germany.

Fernando Dangond (F)

EMD Serono Research & Development Institute, Inc, Billerica, MA, USA, an affiliate of Merck KGaA, Darmstadt, Germany.

Dominic Jack (D)

Merck KGaA, Darmstadt, Germany.

Lori A Lebson (LA)

EMD Serono, Inc, Rockland, MA, USA, an affiliate of Merck KGaA, Darmstadt, Germany.

Thomas P Leist (TP)

Comprehensive Multiple Sclerosis Center, Jefferson University Hospital, Philadelphia, PA, USA.

Classifications MeSH