Renal impairment assessment on adults living nearby a landfill: Early kidney dysfunction biomarkers linked to the environmental exposure to heavy metals.
Biomarkers
Cadmium
Landfill
Lead
Nephrotoxicity
Population
Journal
Toxicology reports
ISSN: 2214-7500
Titre abrégé: Toxicol Rep
Pays: Ireland
ID NLM: 101630272
Informations de publication
Date de publication:
2021
2021
Historique:
received:
02
01
2021
revised:
12
02
2021
accepted:
14
02
2021
entrez:
15
3
2021
pubmed:
16
3
2021
medline:
16
3
2021
Statut:
epublish
Résumé
The aim of this study was to assess the integrity and kidney overall functional capacity of subjects exposed to landfill emissions. Urine and blood levels of Pb and Cd, and several of the newly biomarkers of nephrotoxicity (Kim Injury Molecule 1 (KIM-1), alpha-1 Microglobulin (α1 M), beta-2 Microglobulin (β2 M), Cystatin-C (Cyst C), Clusterin, alpha-glutathione S-transferase (GSTα), pi-glutathione S-transferase (GSTπ), Tissue Inhibitor of Metalloproteinase-1 (TIMP1), Calbindin, Neutrophil Gelatinase-Associated Lipocalin (NGAL), Osteopontin (OPN), (Retinol Binding Protein(RBP), Liver-type Fatty Acid-Binding Protein (FABP-1), Trefoil Factor 3 (TFF3), Collagen VI) were measured in order to assess glomerular and tubule damage in adults living near a landfill. Our results indicate glomerular dysfunction in exposed subjects, and supported evidence of necrosis of proximal and distal tubule epithelial cells as specific biomarkers began to appear in the urine. Positive correlation by Pearson test were obtained between : blood Pb and B-OPN, B-Cyst C, Calbindin, U-KIM-1, TIMP1, U-OPN, and U-Clusterin; and also, between urinary Cd and TIMP1, B-Clusterin, U-OPN, FABP-1, Albumin, and U-Clusterin. The relation between biomarkers of Cd/Pb exposure and early effect biomarkers in this study clearly predicts the future risk of severe kidney injury in subjects living close to the landfill.
Identifiants
pubmed: 33717991
doi: 10.1016/j.toxrep.2021.02.009
pii: S2214-7500(21)00026-3
pmc: PMC7932908
doi:
Types de publication
Journal Article
Langues
eng
Pagination
386-394Informations de copyright
© 2021 Published by Elsevier B.V.
Déclaration de conflit d'intérêts
The authors report no declarations of interest.
Références
Free Radic Biol Med. 2012 Aug 15;53(4):742-57
pubmed: 22705365
Environ Health. 2009 Dec 23;8:60
pubmed: 20030820
Br J Cancer. 2002 Jun 5;86(11):1732-6
pubmed: 12087458
J Am Coll Cardiol. 2011 Apr 26;57(17):1752-61
pubmed: 21511111
Ann Clin Biochem. 2012 Mar;49(Pt 2):190-3
pubmed: 22323662
J Cell Physiol. 2013 May;228(5):917-24
pubmed: 23086807
Toxicology. 2010 Nov 9;277(1-3):49-58
pubmed: 20816719
Biol Trace Elem Res. 2014 Jun;158(3):289-96
pubmed: 24652630
Expert Opin Drug Metab Toxicol. 2006 Oct;2(5):697-713
pubmed: 17014390
Curr Med Chem. 2016;23(19):1981-97
pubmed: 26860999
Clin Transl Sci. 2008 Dec;1(3):200-8
pubmed: 19212447
Am J Nephrol. 2004 May-Jun;24(3):307-15
pubmed: 15148457
Environ Health. 2011 Jun 02;10:53
pubmed: 21635784
Sci Total Environ. 2007 May 15;377(2-3):165-72
pubmed: 17379277
J Thorac Dis. 2016 May;8(5):E305-11
pubmed: 27162688
Kidney Int. 2011 Aug;80(4):405-14
pubmed: 21412214
Environ Pollut. 2015 Nov;206:247-55
pubmed: 26196314
Environ Res. 2015 Feb;137:467-74
pubmed: 25701728
Toxicol Lett. 2013 Oct 24;222(2):233-8
pubmed: 23806787
Nephrology (Carlton). 2010 Jun;15(4):419-28
pubmed: 20609093
J Trace Elem Med Biol. 2006;20(4):253-62
pubmed: 17098585
Int J Epidemiol. 2016 Jun;45(3):806-15
pubmed: 27222499
Nat Biotechnol. 2010 May;28(5):463-9
pubmed: 20458316
Ceylon Med J. 2018 Dec 26;62(4):210-217
pubmed: 29390596
Kidney Int. 2010 Jun;77(11):1020-30
pubmed: 20164823
Clin Chem Lab Med. 2013 Sep;51(9):1795-802
pubmed: 23648635
Front Med (Lausanne). 2017 Jun 15;4:73
pubmed: 28664159
Minerva Urol Nefrol. 2016 Oct;68(5):456-61
pubmed: 25923545
J Expo Sci Environ Epidemiol. 2014 Jul;24(4):388-97
pubmed: 24736101
Nephrol Dial Transplant. 2014 Jul;29(7):1301-11
pubmed: 24385545
J Am Coll Cardiol. 2012 Jan 17;59(3):246-55
pubmed: 22240130
Ecotoxicol Environ Saf. 2012 Apr;78:195-205
pubmed: 22169892
Clin Chim Acta. 2006 Mar;365(1-2):310-8
pubmed: 16248993
Hum Exp Toxicol. 2012 Dec;31(12):1280-91
pubmed: 22837546
Toxicol Appl Pharmacol. 2011 Jul 15;254(2):154-66
pubmed: 21034764
Circ Cardiovasc Interv. 2015 Sep;8(9):e002673
pubmed: 26333343
Am J Kidney Dis. 2016 Dec;68(6):892-900
pubmed: 27663042
Toxicol Appl Pharmacol. 2009 Aug 1;238(3):306-14
pubmed: 19371613
Occup Environ Med. 2014 Dec;71(12):848-54
pubmed: 25286916
Crit Care. 2007;11(4):R84
pubmed: 17678545
J Am Soc Nephrol. 2011 Sep;22(9):1748-57
pubmed: 21836143
Environ Toxicol. 2013 Oct;28(10):563-70
pubmed: 21786387
J Korean Med Sci. 2008 Jun;23(3):452-8
pubmed: 18583882
Springerplus. 2013 Oct 17;2:533
pubmed: 24255836
Experientia. 1984 Feb 15;40(2):143-52
pubmed: 6365580
Curr Opin Nephrol Hypertens. 2016 May;25(3):226-31
pubmed: 27023837
Nat Biotechnol. 2010 May;28(5):436-40
pubmed: 20458311
Nephrol Dial Transplant. 2011 May;26(5):1717-23
pubmed: 21257679