EGFR variant allele frequency predicts EGFR-TKI efficacy in lung adenocarcinoma: a multicenter study.
Epidermal growth factor receptor mutation (EGFR mutation)
lung adenocarcinoma (LADC)
variant allele frequency (VAF)
Journal
Translational lung cancer research
ISSN: 2218-6751
Titre abrégé: Transl Lung Cancer Res
Pays: China
ID NLM: 101646875
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
entrez:
15
3
2021
pubmed:
16
3
2021
medline:
16
3
2021
Statut:
ppublish
Résumé
Although lung adenocarcinoma (LADC) with sensitizing mutations of the epidermal growth factor receptor ( Eighty-nine Caucasian advanced-stage LADC patients with known exon-specific Of 89 Our study suggests that high (≥70%) EGFR-aVAF of tumoral tissue predicts benefit from EGFR-TKI treatment in advanced LADC and, moreover, that exon 19
Sections du résumé
BACKGROUND
BACKGROUND
Although lung adenocarcinoma (LADC) with sensitizing mutations of the epidermal growth factor receptor (
METHODS
METHODS
Eighty-nine Caucasian advanced-stage LADC patients with known exon-specific
RESULTS
RESULTS
Of 89
CONCLUSIONS
CONCLUSIONS
Our study suggests that high (≥70%) EGFR-aVAF of tumoral tissue predicts benefit from EGFR-TKI treatment in advanced LADC and, moreover, that exon 19
Identifiants
pubmed: 33718012
doi: 10.21037/tlcr-20-814
pii: tlcr-10-02-662
pmc: PMC7947383
doi:
Types de publication
Journal Article
Langues
eng
Pagination
662-674Informations de copyright
2021 Translational Lung Cancer Research. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/tlcr-20-814). The authors have no conflicts of interest to declare.
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