Mitophagy in Pancreatic Cancer.
PDAC - pancreatic ductal adenocarcinoma
autophagy
mitophagy
therapy
tumorigenesis
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2021
2021
Historique:
received:
11
10
2020
accepted:
22
01
2021
entrez:
15
3
2021
pubmed:
16
3
2021
medline:
16
3
2021
Statut:
epublish
Résumé
Pancreatic ductal adenocarcinoma (PDAC), one of the most aggressive solid malignancies, is characterized by the presence of oncogenic KRAS mutations, poor response to current therapies, prone to metastasis, and a low 5-year overall survival rate. Macroautophagy (herein referred to as autophagy) is a lysosome-dependent degradation system that forms a series of dynamic membrane structures to engulf, degrade, and recycle various cargoes, such as unused proteins, damaged organelles, and invading pathogens. Autophagy is usually upregulated in established cancers, but it plays a dual role in the regulation of the initiation and progression of PDAC. As a type of selective autophagy, mitophagy is a mitochondrial quality control mechanism that uses ubiquitin-dependent (e.g., the PINK1-PRKN pathway) and -independent (e.g., BNIP3L/NIX, FUNDC1, and BNIP3) pathways to regulate mitochondrial turnover and participate in the modulation of metabolism and cell death. Genetically engineered mouse models indicate that the loss of PINK1 or PRKN promotes, whereas the depletion of BNIP3L inhibits oncogenic KRAS-driven pancreatic tumorigenesis. Mitophagy also play a dual role in the regulation of the anticancer activity of certain cytotoxic agents (e.g., rocaglamide A, dichloroacetate, fisetin, and P. suffruticosa extracts) in PDAC cells or xenograft models. In this min-review, we summarize the latest advances in understanding the complex role of mitophagy in the occurrence and treatment of PDAC.
Identifiants
pubmed: 33718171
doi: 10.3389/fonc.2021.616079
pmc: PMC7953903
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
616079Informations de copyright
Copyright © 2021 Xie, Liu, Kang and Tang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Mol Cell Biol. 2008 Sep;28(18):5747-63
pubmed: 18644871
Cancer Res. 2014 Jun 1;74(11):2913-21
pubmed: 24840647
J Cell Sci. 2018 Sep 20;131(18):
pubmed: 30237248
Nat Rev Mol Cell Biol. 2018 Jan 23;19(2):93-108
pubmed: 29358684
Front Pharmacol. 2019 Sep 03;10:968
pubmed: 31551778
Nat Med. 2019 Apr;25(4):628-640
pubmed: 30833752
Front Cell Dev Biol. 2020 Jun 03;8:431
pubmed: 32582708
Oncogene. 2013 Jan 17;32(3):352-62
pubmed: 22410778
Sci Rep. 2016 Nov 28;6:37594
pubmed: 27892481
Cell Res. 2017 Jul;27(7):916-932
pubmed: 28374746
Cell. 2019 Jan 10;176(1-2):11-42
pubmed: 30633901
Gut. 2020 Aug 14;:
pubmed: 32816920
Cells. 2020 Apr 24;9(4):
pubmed: 32344698
Cancer Manag Res. 2019 Apr 17;11:3295-3313
pubmed: 31114366
Cell Death Dis. 2016 Jul 14;7:e2295
pubmed: 27415425
Cancer Lett. 2013 May 28;332(2):346-58
pubmed: 21078544
Autophagy. 2018;14(2):190-198
pubmed: 28813180
Cancer Gene Ther. 2020 May;27(5):267-269
pubmed: 31467365
Phytomedicine. 2018 Jul 15;46:184-192
pubmed: 30097117
Nat Commun. 2020 Dec 11;11(1):6339
pubmed: 33311482
Autophagy. 2018;14(9):1481-1498
pubmed: 29956571
Autophagy. 2016 Dec;12(12):2374-2385
pubmed: 27754761
Cell Metab. 2011 Jun 8;13(6):701-11
pubmed: 21641551
Biology (Basel). 2019 Dec 28;9(1):
pubmed: 31905604
FEBS J. 2015 Dec;282(24):4672-8
pubmed: 26432171
Nature. 2018 Sep;561(7722):258-262
pubmed: 30135585
Dev Cell. 2018 Aug 20;46(4):441-455.e8
pubmed: 30100261
Autophagy. 2015;11(1):28-45
pubmed: 25484070
Front Cell Dev Biol. 2018 Nov 13;6:147
pubmed: 30483501
Cell Res. 2019 May;29(5):347-364
pubmed: 30948788
Cancers (Basel). 2019 Dec 25;12(1):
pubmed: 31881642
Autophagy. 2019 Nov;15(11):2033-2035
pubmed: 31441366
Nat Commun. 2015 Jul 06;6:7527
pubmed: 26146385
Cancer Cell. 2005 May;7(5):469-83
pubmed: 15894267
Nat Rev Mol Cell Biol. 2018 Jun;19(6):349-364
pubmed: 29618831
Oncogene. 2019 May;38(19):3729-3742
pubmed: 30664690
Front Cell Dev Biol. 2020 Nov 11;8:594203
pubmed: 33262988
JCI Insight. 2019 Jul 23;5:
pubmed: 31335325
Cell Death Dis. 2018 Jan 26;9(2):133
pubmed: 29374159
Mol Biol Cell. 2013 Apr;24(8):1153-62
pubmed: 23427266
Mol Med Rep. 2020 Jul;22(1):398-404
pubmed: 32377725
Cell. 2017 Jan 12;168(1-2):224-238.e10
pubmed: 28017329
Cell Death Dis. 2019 Feb 13;10(2):142
pubmed: 30760707
Cancers (Basel). 2019 Nov 26;11(12):
pubmed: 31769431
Antioxid Redox Signal. 2013 Feb 20;18(6):677-91
pubmed: 22871044
Cell Mol Biol Lett. 2016 Dec 13;21:29
pubmed: 28536631
Nature. 2016 Apr 14;532(7598):245-9
pubmed: 27049944
Nat Cell Biol. 2018 Mar;20(3):233-242
pubmed: 29476151
Nat Cell Biol. 2012 Jan 22;14(2):177-85
pubmed: 22267086
Autophagy. 2020 Mar 18;:1-13
pubmed: 32186434
Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):E4439-48
pubmed: 25294927
Elife. 2014 Jun 04;3:e01958
pubmed: 24898855
Genes Dev. 2013 Jul 1;27(13):1447-61
pubmed: 23824538
EMBO Rep. 2017 Jun;18(6):947-961
pubmed: 28381481
Cancers (Basel). 2018 Jan 29;10(2):
pubmed: 29382159
Nat Cell Biol. 2010 Feb;12(2):119-31
pubmed: 20098416
Cancer Res. 2017 Apr 15;77(8):2064-2077
pubmed: 28130223
Front Oncol. 2017 Dec 01;7:295
pubmed: 29250487
Autophagy. 2015 Apr 3;11(4):595-606
pubmed: 25915564
Hum Mol Genet. 2016 Aug 15;25(16):3476-3490
pubmed: 27334109
Cancer Res. 2012 Apr 15;72(8):1996-2005
pubmed: 22345153
Nat Cell Biol. 2018 Sep;20(9):1013-1022
pubmed: 30154567
Nat Rev Cancer. 2017 Sep;17(9):528-542
pubmed: 28751651
Cancer Discov. 2018 Mar;8(3):276-287
pubmed: 29317452
Br J Cancer. 2021 Jan;124(2):333-344
pubmed: 32929194
Nat Commun. 2018 Apr 26;9(1):1677
pubmed: 29700304
NPJ Precis Oncol. 2019 Jun 3;3:16
pubmed: 31231686
Hum Mol Genet. 2015 May 1;24(9):2528-38
pubmed: 25612572
Cell. 2014 Mar 27;157(1):65-75
pubmed: 24679527
Nature. 2013 Dec 12;504(7479):296-300
pubmed: 24305049
Cancer Discov. 2019 Sep;9(9):1268-1287
pubmed: 31263025
Science. 1996 Jul 26;273(5274):501-3
pubmed: 8662539
Science. 1989 Oct 20;246(4928):382-5
pubmed: 2799391
Nature. 2020 May;581(7806):100-105
pubmed: 32376951
Autophagy. 2019 Jan;15(1):172-173
pubmed: 30252570
Pancreas. 2013 Jul;42(5):829-35
pubmed: 23429496
Cells. 2019 May 18;8(5):
pubmed: 31109089
Nat Rev Mol Cell Biol. 2020 Feb;21(2):85-100
pubmed: 31636403
J Cell Biol. 2010 Sep 6;190(5):881-92
pubmed: 20819940
Cancers (Basel). 2020 Sep 01;12(9):
pubmed: 32882923
Biomed Pharmacother. 2020 Jan;121:109521
pubmed: 31689601
Dev Cell. 2019 May 20;49(4):509-525.e12
pubmed: 30982665
Free Radic Biol Med. 2010 Dec 1;49(11):1603-16
pubmed: 20840865
Autophagy. 2020 Nov 20;:1-22
pubmed: 33161807
Biochem Biophys Res Commun. 2018 Oct 7;504(3):582-589
pubmed: 29438712
EMBO Mol Med. 2014 Dec 15;7(1):78-101
pubmed: 25510912
Science. 2020 Apr 3;368(6486):85-89
pubmed: 32241947
Cold Spring Harb Perspect Med. 2018 Sep 4;8(9):
pubmed: 29229669
Am J Cancer Res. 2012;2(4):383-96
pubmed: 22860230
Endocrine. 2020 May;68(2):438-447
pubmed: 32114655
Autophagy. 2020 Nov;16(11):2069-2083
pubmed: 31920150
Cell Rep. 2019 Aug 13;28(7):1845-1859.e5
pubmed: 31412251
Immunity. 2015 Aug 18;43(2):331-42
pubmed: 26253785
Cell Chem Biol. 2020 Apr 16;27(4):420-435
pubmed: 32160513
Autophagy. 2020 Mar;16(3):486-500
pubmed: 31177911
EMBO J. 2000 Nov 1;19(21):5720-8
pubmed: 11060023
Nat Commun. 2020 May 29;11(1):2682
pubmed: 32472071
Cell Death Differ. 2018 Mar;25(3):486-541
pubmed: 29362479
Nature. 2015 Aug 20;524(7565):309-314
pubmed: 26266977
Nat Cell Biol. 2013 Oct;15(10):1197-1205
pubmed: 24036476
Proc Natl Acad Sci U S A. 2012 May 1;109(18):7031-6
pubmed: 22509024
Cancer Cell. 2003 Dec;4(6):437-50
pubmed: 14706336
Nature. 2011 Dec 1;480(7375):113-7
pubmed: 22020285
Autophagy. 2016 Aug 2;12(8):1425-8
pubmed: 27245739
Gastroenterology. 2018 Apr;154(5):1480-1493
pubmed: 29248440
Gut. 2020 Feb;69(2):317-328
pubmed: 31201285
Gastroenterology. 2017 Nov;153(5):1429-1443.e5
pubmed: 28764929
Nature. 2008 Jul 10;454(7201):232-5
pubmed: 18454133
Semin Cancer Biol. 2020 Nov;66:89-100
pubmed: 30880243
Cancer Immunol Res. 2016 Jun;4(6):520-30
pubmed: 27068336
Sci Adv. 2019 Jul 24;5(7):eaaw2238
pubmed: 31355331