Oxygen Deprivation Modulates EGFR and PD-L1 in Squamous Cell Carcinomas of the Head and Neck.
PD-L1
PI3K/AKT
Ras-MAPK pathway
apoptosis
autophagy
epidermal growth factor receptor
head and neck cancer
hypoxia
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2021
2021
Historique:
received:
30
10
2020
accepted:
13
01
2021
entrez:
15
3
2021
pubmed:
16
3
2021
medline:
16
3
2021
Statut:
epublish
Résumé
Abundance and signaling of the epidermal growth factor receptor (EGFR) and programmed cell death protein ligand 1 (PD-L1) in head and neck squamous cell carcinoma (HNSCC) are not only genetically determined but are also subject to the traits of the tumor microenvironment, which has hitherto not been clarified completely. We investigated the impact of hypoxia on the EGFR system and on PD-L1 in six HPV negative HNSCC cell lines
Identifiants
pubmed: 33718186
doi: 10.3389/fonc.2021.623964
pmc: PMC7953989
doi:
Types de publication
Journal Article
Langues
eng
Pagination
623964Informations de copyright
Copyright © 2021 Zahnreich, Gebrekidan, Multhoff, Vaupel, Schmidberger and Mayer.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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