Near-Infrared Fluorescence Imaging and Photodynamic Therapy for Liver Tumors.

indocyanine green lactosome liver surgery navigation liver tumors near-infrared fluorescence imaging photodynamic therapy

Journal

Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867

Informations de publication

Date de publication:
2021
Historique:
received: 06 12 2020
accepted: 05 02 2021
entrez: 15 3 2021
pubmed: 16 3 2021
medline: 16 3 2021
Statut: epublish

Résumé

Surgery with fluorescence equipment has improved to treat the malignant viscera, including hepatobiliary and pancreatic neoplasms. In both open and minimally invasive surgeries, optical imaging using near-infrared (NIR) fluorescence is used to assess anatomy and function in real time. Here, we review a variety of publications related to clinical applications of NIR fluorescence imaging in liver surgery. We have developed a novel nanoparticle (indocyanine green lactosome) that is biocompatible and can be used for imaging cancer tissues and also as a drug delivery system. To date, stable particles are formed in blood and have an ~10-20 h half-life. Particles labeled with a NIR fluorescent agent have been applied to cancer tissues by the enhanced permeability and retention effect in animals. Furthermore, this article reviews recent developments in photodynamic therapy with NIR fluorescence imaging, which may contribute and accelerate the innovative treatments for liver tumors.

Identifiants

pubmed: 33718233
doi: 10.3389/fonc.2021.638327
pmc: PMC7947679
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

638327

Informations de copyright

Copyright © 2021 Kaibori, Kosaka, Matsui, Ishizaki, Matsushima, Tsuda, Hishikawa, Okumura and Sekimoto.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Masaki Kaibori (M)

Department of Surgery, Kansai Medical University, Osaka, Japan.

Hisashi Kosaka (H)

Department of Surgery, Kansai Medical University, Osaka, Japan.

Kosuke Matsui (K)

Department of Surgery, Kansai Medical University, Osaka, Japan.

Morihiko Ishizaki (M)

Department of Surgery, Kansai Medical University, Osaka, Japan.

Hideyuki Matsushima (H)

Department of Surgery, Kansai Medical University, Osaka, Japan.

Takumi Tsuda (T)

Department of Surgery, Kansai Medical University, Osaka, Japan.

Hidehiko Hishikawa (H)

Department of Surgery, Kansai Medical University, Osaka, Japan.

Tadayoshi Okumura (T)

Department of Surgery, Kansai Medical University, Osaka, Japan.

Mitsugu Sekimoto (M)

Department of Surgery, Kansai Medical University, Osaka, Japan.

Classifications MeSH