The Role of Exosomes in Pancreatic Cancer From Bench to Clinical Application: An Updated Review.
biomarker
cell-to-cell communication
exosome
pancreatic cancer
therapeutic vehicle
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2021
2021
Historique:
received:
21
12
2020
accepted:
12
01
2021
entrez:
15
3
2021
pubmed:
16
3
2021
medline:
16
3
2021
Statut:
epublish
Résumé
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most dismal gastrointestinal malignancies with an overall 5-year survival rate of 8%-9%. The intra-tumor heterogeneity and special tumor microenvironment in PDAC make it challenging to develop effective treatment strategies. Exosomes are extracellular vesicles that originate from the endosomes and have a diameter of 40-160 nm. A growing body of evidence has shown that exosomes play vital roles in tumor initiation and development. Recently, extensive application of exosomes as biomarkers and drug carriers has rendered them attractive in the field of PDAC. This review summarizes the latest progress in the methodologies for isolation, modification, and tracking of exosomes, exosome-mediated cell-to-cell communication, clinical applications of exosome as minimally invasive liquid biopsy and drugs carriers, as well as their involvement in the angiogenic regulation in PDAC. In spite of these advancements, some obstacles are still required to be overcome to use the exosome-based technologies for early diagnosis or improvement of prognosis of patients with PDAC.
Identifiants
pubmed: 33718244
doi: 10.3389/fonc.2021.644358
pmc: PMC7952979
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
644358Informations de copyright
Copyright © 2021 Chen, Wang, Kornmann, Tian and Yang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Adv Drug Deliv Rev. 2013 Mar;65(3):383-90
pubmed: 22921594
J Clin Oncol. 2010 Aug 1;28(22):3617-22
pubmed: 20606091
Oncogene. 2017 Aug 24;36(34):4929-4942
pubmed: 28436951
Blood Cells Mol Dis. 2005 Jul-Aug;35(1):1-10
pubmed: 15893944
Cancer Cell. 2014 Nov 10;26(5):707-21
pubmed: 25446899
Nat Rev Cancer. 2016 Aug 23;16(9):582-98
pubmed: 27550820
Nat Cell Biol. 2015 Jun;17(6):816-26
pubmed: 25985394
Blood. 2014 Dec 11;124(25):3748-57
pubmed: 25320245
JCI Insight. 2018 Apr 19;3(8):
pubmed: 29669940
J Biotechnol. 2013 May 20;165(2):77-84
pubmed: 23562828
Nat Cell Biol. 2008 Dec;10(12):1470-6
pubmed: 19011622
Life Sci. 2020 May 15;249:117447
pubmed: 32087234
N Engl J Med. 2014 Sep 11;371(11):1039-49
pubmed: 25207767
Oncotarget. 2016 Sep 6;7(36):58649-58658
pubmed: 27462915
Cell Oncol (Dordr). 2020 Feb;43(1):123-136
pubmed: 31713003
J Control Release. 2016 Apr 28;228:179-190
pubmed: 26941033
Oncogene. 2018 Jul;37(28):3822-3838
pubmed: 29643475
Anticancer Res. 2016 Mar;36(3):1119-26
pubmed: 26977007
Micromachines (Basel). 2020 May 15;11(5):
pubmed: 32429185
Carbohydr Polym. 2018 Dec 15;202:323-333
pubmed: 30287007
Theranostics. 2018 Nov 13;8(21):5986-5994
pubmed: 30613276
Mol Cancer. 2019 Apr 2;18(1):75
pubmed: 30940145
Transl Oncol. 2019 Nov;12(11):1395-1403
pubmed: 31400579
CA Cancer J Clin. 2020 Jan;70(1):7-30
pubmed: 31912902
ACS Nano. 2015 Mar 24;9(3):2321-7
pubmed: 25672598
Nat Biotechnol. 2011 Apr;29(4):341-5
pubmed: 21423189
Leukemia. 2014 Apr;28(4):970-3
pubmed: 24445866
J Extracell Vesicles. 2017 Jun 6;6(1):1324730
pubmed: 28717420
Nat Cell Biol. 2018 Mar;20(3):332-343
pubmed: 29459780
Nanotechnology. 2018 Apr 27;29(17):175701
pubmed: 29438102
Cells. 2019 Apr 03;8(4):
pubmed: 30987213
J Extracell Vesicles. 2014 Mar 26;3:
pubmed: 24683445
Nature. 2017 Jun 22;546(7659):498-503
pubmed: 28607485
J Biol Chem. 2014 Feb 14;289(7):3869-75
pubmed: 24398677
Int J Cancer. 2015 Jun 1;136(11):2616-27
pubmed: 25388097
J Hepatobiliary Pancreat Sci. 2019 Feb;26(2):63-72
pubmed: 30561106
Adv Drug Deliv Rev. 2015 Jan;81:16-33
pubmed: 25453266
Mol Cancer Res. 2020 Feb;18(2):300-310
pubmed: 31662449
Cancer Cell. 2012 Mar 20;21(3):418-29
pubmed: 22439937
Immunity. 2020 Mar 17;52(3):542-556.e13
pubmed: 32187520
Nanoscale. 2019 Jan 23;11(4):1531-1537
pubmed: 30623961
Oncotarget. 2017 Aug 18;8(44):77028-77040
pubmed: 29100367
BMC Cancer. 2018 Jan 31;18(1):116
pubmed: 29385987
Lasers Med Sci. 2020 Apr;35(3):531-545
pubmed: 31529349
J Transl Med. 2018 Jan 9;16(1):1
pubmed: 29316942
Nat Nanotechnol. 2016 Nov;11(11):936-940
pubmed: 27479757
J Hepatobiliary Pancreat Sci. 2018 Feb;25(2):155-161
pubmed: 29130611
Nat Cell Biol. 2007 Jun;9(6):654-9
pubmed: 17486113
Adv Healthc Mater. 2019 Mar;8(6):e1801268
pubmed: 30663276
Biochem Biophys Res Commun. 2018 Jul 20;502(3):324-331
pubmed: 29787762
Sci Rep. 2015 Oct 26;5:15636
pubmed: 26497063
Invest New Drugs. 2012 Jun;30(3):1175-83
pubmed: 21424698
Am J Physiol Gastrointest Liver Physiol. 2008 Oct;295(4):G709-17
pubmed: 18669622
Eur Rev Med Pharmacol Sci. 2019 Nov;23(21):9351-9361
pubmed: 31773694
Front Immunol. 2019 Dec 11;10:2819
pubmed: 31921112
Oncotarget. 2018 Apr 10;9(27):19006-19013
pubmed: 29721179
Biomaterials. 2014 Feb;35(7):2383-90
pubmed: 24345736
Cell Physiol Biochem. 2018;51(2):610-629
pubmed: 30458449
Lancet. 2011 Aug 13;378(9791):607-20
pubmed: 21620466
Semin Cancer Biol. 2014 Oct;28:58-67
pubmed: 24859748
J Transl Med. 2020 Jun 22;18(1):249
pubmed: 32571337
Eur J Cancer. 2015 Jan;51(1):27-36
pubmed: 25459392
Cancer Res. 2018 Aug 15;78(16):4586-4598
pubmed: 29880482
Mol Ther. 2017 Jun 7;25(6):1269-1278
pubmed: 28412169
Nature. 2015 Jul 9;523(7559):177-82
pubmed: 26106858
Int J Oncol. 2020 Apr;56(4):1025-1033
pubmed: 32319558
Sci Rep. 2018 Sep 19;8(1):14035
pubmed: 30232365
Theranostics. 2020 Feb 19;10(8):3684-3707
pubmed: 32206116
Ann Oncol. 2012 Nov;23(11):2799-2805
pubmed: 22771827
Theranostics. 2019 Jul 28;9(19):5642-5656
pubmed: 31534508
Nat Rev Clin Oncol. 2015 Jun;12(6):319-34
pubmed: 25824606
Ann Surg Oncol. 2019 Jul;26(7):2104-2111
pubmed: 30820789
Cell. 1998 Sep 18;94(6):715-25
pubmed: 9753319
Biochim Biophys Acta Gen Subj. 2018 May;1862(5):1091-1100
pubmed: 29410228
J Cell Physiol. 2020 Oct;235(10):6345-6356
pubmed: 32216070
Exp Cell Res. 2019 Oct 1;383(1):111543
pubmed: 31374207
Biomed Pharmacother. 2018 Dec;108:1135-1140
pubmed: 30372814
Int J Nanomedicine. 2016 Jun 01;11:2481-90
pubmed: 27330291
Hepatobiliary Surg Nutr. 2020 Feb;9(1):89-91
pubmed: 32140487
J Extracell Vesicles. 2015 Jul 17;4:27031
pubmed: 26194179
Mol Cancer. 2020 Mar 30;19(1):68
pubmed: 32228703
Mol Ther. 2013 Jan;21(1):185-91
pubmed: 23032975