Diets and Cellular-Derived Microparticles: Weighing a Plausible Link With Cerebral Small Vessel Disease.
cerebral small vessel disease
diet
microparticles
microthrombosis
neurodegeneration
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2021
2021
Historique:
received:
23
11
2020
accepted:
19
01
2021
entrez:
15
3
2021
pubmed:
16
3
2021
medline:
16
3
2021
Statut:
epublish
Résumé
Cerebral small vessel disease (CSVD) represents a spectrum of pathological processes of various etiologies affecting the brain microcirculation that can trigger neuroinflammation and the subsequent neurodegenerative cascade. Prevalent with aging, CSVD is a recognized risk factor for stroke, vascular dementia, Alzheimer disease, and Parkinson disease. Despite being the most common neurodegenerative condition with cerebrocardiovascular axis, understanding about it remains poor. Interestingly, modifiable risk factors such as unhealthy diet including high intake of processed food, high-fat foods, and animal by-products are known to influence the non-neural peripheral events, such as in the gastrointestinal tract and cardiovascular stress through cellular inflammation and oxidation. One key outcome from such events, among others, includes the cellular activations that lead to elevated levels of endogenous cellular-derived circulating microparticles (MPs). MPs can be produced from various cellular origins including leukocytes, platelets, endothelial cells, microbiota, and microglia. MPs could act as microthrombogenic procoagulant that served as a plausible culprit for the vulnerable end-artery microcirculation in the brain as the end-organ leading to CSVD manifestations. However, little attention has been paid on the potential role of MPs in the onset and progression of CSVD spectrum. Corroboratively, the formation of MPs is known to be influenced by diet-induced cellular stress. Thus, this review aims to appraise the body of evidence on the dietary-related impacts on circulating MPs from non-neural peripheral origins that could serve as a plausible microthrombosis in CSVD manifestation as a precursor of neurodegeneration. Here, we elaborate on the pathomechanical features of MPs in health and disease states; relevance of dietary patterns on MP release; preclinical studies pertaining to diet-based MPs contribution to disease; MP level as putative surrogates for early disease biomarkers; and lastly, the potential of MPs manipulation with diet-based approach as a novel preventive measure for CSVD in an aging society worldwide.
Identifiants
pubmed: 33718454
doi: 10.3389/fcvm.2021.632131
pmc: PMC7943466
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
632131Informations de copyright
Copyright © 2021 Nassir, Ghazali, Hashim, Idris, Yuen, Hui, Norman, Gau, Jayabalan, Na, Feng, Ong, Abdul Hamid, Ahamed and Mustapha.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Neurology. 2008 Sep 9;71(11):804-11
pubmed: 18685136
Ann Neurol. 2012 Oct;72(4):610-24
pubmed: 23109155
Blood. 2006 May 1;107(9):3537-45
pubmed: 16449527
Diabetes Metab Syndr Obes. 2019 Apr 12;12:485-493
pubmed: 31043798
Am J Clin Nutr. 2018 Jun 1;107(6):876-882
pubmed: 29741564
Obes Rev. 2016 Nov;17(11):1067-1079
pubmed: 27405372
Curr Hypertens Rep. 2018 Feb 26;20(2):12
pubmed: 29480368
J Pediatr. 2015 Apr;166(4):953-9.e1-3
pubmed: 25684089
Pharmacol Rep. 2008 Jan-Feb;60(1):75-84
pubmed: 18276988
Public Health Nutr. 2006 Dec;9(8A):1073-6
pubmed: 17378943
Hamostaseologie. 2019 Jun;39(2):152-163
pubmed: 30722070
Lancet Neurol. 2013 Aug;12(8):822-38
pubmed: 23867200
BMJ. 2019 Sep 4;366:l4897
pubmed: 31484644
Front Biosci (Landmark Ed). 2018 Jan 1;23(3):432-457
pubmed: 28930554
Am J Physiol Cell Physiol. 2014 Apr 1;306(7):C621-33
pubmed: 24452373
Clin Colon Rectal Surg. 2012 Dec;25(4):228-35
pubmed: 24294125
BMJ. 2012 Mar 15;344:e1454
pubmed: 22422870
Arterioscler Thromb Vasc Biol. 2012 Oct;32(10):2394-404
pubmed: 22859493
Neurosurgery. 2006 Oct;59(4):781-7; discussion 787-8
pubmed: 16915120
Br J Pharmacol. 2015 Dec;172(23):5647-60
pubmed: 25339093
Blood. 2017 Apr 20;129(16):2291-2302
pubmed: 28223279
J Stroke. 2018 Sep;20(3):302-320
pubmed: 30309226
Thromb Res. 2019 Oct;182:64-74
pubmed: 31450010
Eur J Nutr. 2011 Feb;50(1):61-9
pubmed: 20499072
Br J Nutr. 2012 Aug;108(4):699-709
pubmed: 22894912
Nutrients. 2020 Jul 24;12(8):
pubmed: 32722321
J Neuroinflammation. 2018 Jan 08;15(1):8
pubmed: 29310666
Blood Coagul Fibrinolysis. 2011 Apr;22(3):197-205
pubmed: 21311321
Stroke. 2014 Jun;45(6):1613-9
pubmed: 24811336
Eur J Clin Nutr. 2006 Aug;60(8):978-84
pubmed: 16482073
Cell. 2017 Jun 15;169(7):1276-1290.e17
pubmed: 28602351
Front Pharmacol. 2016 Mar 17;7:61
pubmed: 27014073
Semin Thromb Hemost. 2014 Mar;40(2):214-26
pubmed: 24497119
Thromb Res. 2008;122 Suppl 1:S47-54
pubmed: 18691500
Am J Clin Nutr. 2011 Feb;93(2):267-74
pubmed: 21123460
J Cereb Blood Flow Metab. 2016 Jan;36(1):72-94
pubmed: 26058695
Ann Neurol. 2015 Feb;77(2):251-61
pubmed: 25428654
Am J Clin Nutr. 2014 Nov;100(5):1232-43
pubmed: 25332321
J Nutr Biochem. 2015 Jun;26(6):626-32
pubmed: 25769436
Am J Respir Crit Care Med. 2007 Mar 15;175(6):612-7
pubmed: 17341649
PLoS One. 2009;4(3):e4722
pubmed: 19266099
Front Neurosci. 2019 Dec 04;13:1291
pubmed: 31866808
Clin Appl Thromb Hemost. 2010 Feb;16(1):26-32
pubmed: 19671561
Analyst. 2003 Jun;128(6):581-8
pubmed: 12866871
Diabetes Metab Syndr. 2015 Jan-Mar;9(1):51-4
pubmed: 25450817
Nutrition. 2013 Apr;29(4):611-8
pubmed: 23466047
JAMA Psychiatry. 2017 Jul 1;74(7):729-739
pubmed: 28564681
Int Psychogeriatr. 2007 Apr;19(2):295-305
pubmed: 17054820
Am J Physiol Lung Cell Mol Physiol. 2012 Sep;303(5):L364-81
pubmed: 22728467
J Cereb Blood Flow Metab. 2016 Jan;36(1):264-74
pubmed: 25899292
Eur Respir J. 2009 Mar;33(3):574-80
pubmed: 19047314
Neurobiol Aging. 2009 Mar;30(3):337-52
pubmed: 17869382
Clin Nutr. 2019 Aug;38(4):1620-1628
pubmed: 30219609
Blood Cells Mol Dis. 1995;21(3):217-31; discussion 231a
pubmed: 8673474
BMJ Open. 2016 Jul 13;6(7):e011632
pubmed: 27412107
Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15418-23
pubmed: 19706393
J Hypertens. 2010 Feb;28(2):245-50
pubmed: 19829145
Stroke. 2008 Jan;39(1):55-61
pubmed: 18048865
Methods Mol Biol. 2017;1554:193-200
pubmed: 28185192
Immunity. 2019 Jan 15;50(1):253-271.e6
pubmed: 30471926
J Vasc Res. 2006;43(2):193-204
pubmed: 16410682
Hypertension. 2003 Feb;41(2):211-7
pubmed: 12574084
Am J Clin Nutr. 2010 Jun;91(6):1764-8
pubmed: 20375186
Int J Obes (Lond). 2011 Dec;35(12):1479-86
pubmed: 21386797
Am J Clin Nutr. 2017 Oct;106(4):1131-1141
pubmed: 28855223
Can J Cardiol. 2010 Apr;26(4):140-5
pubmed: 20386775
Crit Care. 2013 Mar 19;17(2):218
pubmed: 23510484
Brain Behav Immun. 2019 Jul;79:284-293
pubmed: 30797044
Microcirculation. 2008 Apr;15(3):225-36
pubmed: 18386218
Atherosclerosis. 2016 May;248:10-6
pubmed: 26978582
Lancet Diabetes Endocrinol. 2016 Aug;4(8):666-676
pubmed: 27283479
Contrib Nephrol. 2011;174:119-128
pubmed: 21921616
Biol Psychiatry. 2017 Dec 1;82(11):e81-e83
pubmed: 29110819
BMC Med. 2017 Feb 24;15(1):41
pubmed: 28231783
Am J Physiol Endocrinol Metab. 2012 Feb 1;302(3):E374-86
pubmed: 22094473
Front Physiol. 2019 Oct 24;10:1317
pubmed: 31708793
J Psychiatry Neurosci. 2016 Apr;41(3):162-8
pubmed: 26505140
Cell Host Microbe. 2012 Oct 18;12(4):509-20
pubmed: 22999859
Nutr Rev. 2013 Aug;71(8):511-27
pubmed: 23865797
Nat Rev Microbiol. 2011 Apr;9(4):233-43
pubmed: 21358670
Mediators Inflamm. 2017;2017:3674390
pubmed: 28484308
PLoS One. 2015 Feb 06;10(2):e0118076
pubmed: 25658337
Front Immunol. 2019 Apr 30;10:914
pubmed: 31114576
J Vasc Surg. 2011 Mar;53(3):743-53
pubmed: 21095090
Biol Psychiatry. 2016 Jul 1;80(1):40-52
pubmed: 26140821
Circulation. 2016 Jan 12;133(2):187-225
pubmed: 26746178
Int J Obes (Lond). 2013 Feb;37(2):216-23
pubmed: 22410962
J Neurochem. 2005 Aug;94(4):1063-76
pubmed: 16092947
Acta Neuropathol. 2019 Feb;137(2):321-341
pubmed: 30580383
Blood Transfus. 2017 Oct;15(6):522-534
pubmed: 28686154
BMC Med. 2013 Mar 07;11:63
pubmed: 23497300
Atherosclerosis. 2010 Feb;208(2):442-50
pubmed: 19712933
Molecules. 2013 Sep 17;18(9):11526-36
pubmed: 24048285
Atherosclerosis. 2014 Jun;234(2):320-8
pubmed: 24727233
J Cereb Blood Flow Metab. 2016 Feb;36(2):302-25
pubmed: 26661176
Cancer Prev Res (Phila). 2011 Feb;4(2):177-84
pubmed: 21209396
Eur Heart J. 2011 Aug;32(16):1958-60
pubmed: 21406442
Circulation. 2001 Jun 12;103(23):2792-8
pubmed: 11401934
Int J Mol Sci. 2018 Dec 11;19(12):
pubmed: 30544955
Eur J Epidemiol. 2013 Nov;28(11):845-58
pubmed: 24158434
Sci Rep. 2015 Nov 10;5:16314
pubmed: 26553743
Stroke. 2005 Feb;36(2):342-7
pubmed: 15637328
Nutr Metab Cardiovasc Dis. 2009 Dec;19(10):697-706
pubmed: 19303267
J Appl Physiol (1985). 2013 Nov;115(10):1481-6
pubmed: 24052032
Maturitas. 2012 Apr;71(4):331-6
pubmed: 22318093
Thromb Haemost. 2001 Apr;85(4):639-46
pubmed: 11341498
J Neuroinflammation. 2018 May 28;15(1):168
pubmed: 29807527
Nat Clin Pract Nephrol. 2006 Oct;2(10):582-93
pubmed: 17003837
Nat Neurosci. 2018 Feb;21(2):240-249
pubmed: 29335605
Transfus Apher Sci. 2015 Oct;53(2):159-67
pubmed: 26584596
J Nutr. 2001 Mar;131(3s):980S-4S
pubmed: 11238801
Best Pract Res Clin Gastroenterol. 2001 Feb;15(1):1-14
pubmed: 11355897
Blood. 2004 Nov 15;104(10):3190-7
pubmed: 15280200
J Acquir Immune Defic Syndr. 2020 Jan 1;83(1):90-98
pubmed: 31809364
Compr Physiol. 2013 Apr;3(2):817-31
pubmed: 23720331
J Am Geriatr Soc. 2008 Sep;56(9):1638-43
pubmed: 18691285
Neurology. 2015 Nov 3;85(18):1569-77
pubmed: 26446068
Br J Nutr. 2012 Jan;107(2):229-41
pubmed: 21733316
J Nutr. 2018 Aug 1;148(8):1323-1332
pubmed: 29982724
Nutrients. 2016 Oct 18;8(10):
pubmed: 27763541
BMC Med. 2015 Jun 16;13:143
pubmed: 26082154
J Atheroscler Thromb. 2018 Oct 1;25(10):1009-1021
pubmed: 29459517
Am J Epidemiol. 2008 Apr 15;167(8):954-61
pubmed: 18270369
JAMA Neurol. 2018 Oct 1;75(10):1256-1263
pubmed: 29946702
Compr Physiol. 2015 Jul 1;5(3):1541-83
pubmed: 26140727
Tissue Barriers. 2018;6(2):e1431038
pubmed: 29424657
Lancet Neurol. 2013 May;12(5):483-97
pubmed: 23602162
Cerebrovasc Dis Extra. 2019;9(1):9-18
pubmed: 30943521
Am J Clin Nutr. 2006 Feb;83(2):284-90
pubmed: 16469985
Br J Nutr. 2014 Apr 14;111(7):1245-52
pubmed: 24286443
Stroke. 2006 Nov;37(11):2816-23
pubmed: 17008622
J Clin Invest. 1998 Jul 1;102(1):136-44
pubmed: 9649567
Food Funct. 2016 Jan;7(1):127-39
pubmed: 26462860
Int J Cancer. 2005 Feb 20;113(5):752-60
pubmed: 15499615
J Biol Chem. 2009 Sep 18;284(38):25602-11
pubmed: 19633358
J Thromb Haemost. 2010 Feb;8(2):315-23
pubmed: 19840362
J Biol Chem. 2011 Jul 1;286(26):23247-53
pubmed: 21561861
Br J Nutr. 2012 Sep;108(5):801-9
pubmed: 22717075
Clin Nutr. 2020 Nov;39(11):3377-3384
pubmed: 32147198
BMJ. 2014 Jul 29;349:g4490
pubmed: 25073782
N Engl J Med. 2018 Jun 21;378(25):2441-2442
pubmed: 29897867
Curr Opin Crit Care. 2005 Oct;11(5):454-60
pubmed: 16175032
Thromb Res. 2010 Apr;125 Suppl 1:S46-8
pubmed: 20153515
Neuroscience. 2016 May 26;323:110-20
pubmed: 26071958
J Nutr. 2015 Jun;145(6):1256-62
pubmed: 25855121
Circ Res. 2012 Jan 20;110(2):356-69
pubmed: 22267840
Curr Diabetes Rev. 2010 Sep;6(5):294-303
pubmed: 20594163
Neurophotonics. 2016 Jul;3(3):031411
pubmed: 27403447
PLoS One. 2014 Jun 12;9(6):e100084
pubmed: 24925270
Hypertens Res. 2018 Oct;41(10):817-827
pubmed: 30120397
Cell. 2017 Aug 10;170(4):649-663.e13
pubmed: 28802038
Anesth Analg. 2019 Aug;129(2):598-607
pubmed: 30451726
Circ Res. 2011 May 13;108(10):1284-97
pubmed: 21566224
Thromb Res. 2015 Feb;135(2):375-81
pubmed: 25523345
J Thromb Haemost. 2018 Feb;16(2):231-241
pubmed: 29193703
J Thromb Haemost. 2004 Oct;2(10):1842-51
pubmed: 15456497
Lancet Gastroenterol Hepatol. 2017 Oct;2(10):747-756
pubmed: 28844808
Neurol Res. 1980;2(3-4):273-82
pubmed: 6111035
J Biol Chem. 1999 Aug 13;274(33):23111-8
pubmed: 10438480
Cytometry B Clin Cytom. 2018 Mar;94(2):334-341
pubmed: 28052584
Thromb Haemost. 2009 Mar;101(3):439-51
pubmed: 19277403
Arterioscler Thromb Vasc Biol. 2007 Aug;27(8):1687-93
pubmed: 17556654
J Intensive Care. 2015 Jan 07;3(1):2
pubmed: 25705427
Best Pract Res Clin Gastroenterol. 2013 Feb;27(1):73-83
pubmed: 23768554
Sci Rep. 2017 Jan 30;7:41637
pubmed: 28134332
Thromb Haemost. 1999 Apr;81(4):561-5
pubmed: 10235439
Stroke. 2010 Apr;41(4):784-9
pubmed: 20167907
J Neuroinflammation. 2017 Mar 15;14(1):47
pubmed: 28292310
Am J Clin Nutr. 2014 Jul;100(1):218-32
pubmed: 24787496
Thromb Res. 2000 Jul 15;99(2):203-8
pubmed: 10946095
Stroke. 2019 Mar;50(3):639-644
pubmed: 30744544
Neuron. 2017 Sep 27;96(1):17-42
pubmed: 28957666
Curr Opin Lipidol. 2002 Feb;13(1):3-9
pubmed: 11790957
J Am Coll Cardiol. 2011 Nov 8;58(20):2047-67
pubmed: 22051327
Circulation. 2010 Jun 1;121(21):2271-83
pubmed: 20479151
Blood. 2006 Sep 15;108(6):1868-76
pubmed: 16720831
Cold Spring Harb Perspect Biol. 2015 Jan 05;7(1):a020412
pubmed: 25561720
Atherosclerosis. 2009 Jun;204(2):544-8
pubmed: 19013573
Nat Rev Immunol. 2009 Jun;9(6):429-39
pubmed: 19461673
Am J Physiol Gastrointest Liver Physiol. 2012 Sep 1;303(5):G589-99
pubmed: 22700822
J Alzheimers Dis. 2015;49(3):863-73
pubmed: 26529206
Eur J Neurol. 2014 Apr;21(4):667-73
pubmed: 24495037
Arterioscler Thromb Vasc Biol. 2011 Jan;31(1):15-26
pubmed: 21160064
Vox Sang. 2009 Apr;96(3):206-12
pubmed: 19175566
Int J Biol Macromol. 2018 Jan;106:878-884
pubmed: 28842200
J Thromb Haemost. 2006 Jun;4(6):1296-302
pubmed: 16706974
Int J Food Sci Nutr. 2014 Feb;65(1):117-23
pubmed: 24059649
Cancer Sci. 2017 May;108(5):824-830
pubmed: 28256033
J Am Coll Cardiol. 2015 Apr 28;65(16):1683-1699
pubmed: 25908074
Int J Alzheimers Dis. 2012;2012:608013
pubmed: 22550606
J Virol. 2019 Oct 29;93(22):
pubmed: 31484749
Obes Rev. 2016 May;17(5):442-54
pubmed: 26990451
Thromb Res. 2017 Jun;154:19-25
pubmed: 28390251
J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Nov 15;827(1):65-75
pubmed: 16183338
Mol Neurodegener. 2019 Aug 16;14(1):34
pubmed: 31419995
Thromb Res. 2007;119(1):45-53
pubmed: 16480759
J Cereb Blood Flow Metab. 2012 Mar;32(3):447-55
pubmed: 22146194
Nutrients. 2014 Aug 19;6(8):3259-73
pubmed: 25195560
Eur J Pharmacol. 2016 Aug 15;785:187-206
pubmed: 26036964
Stroke. 2011 Feb;42(2):494-7
pubmed: 21164137
J Nutr. 2016 Sep;146(9):1684-93
pubmed: 27440261
BMJ Open. 2014 Jan 14;4(1):e003824
pubmed: 24430876
Int J Cardiol. 2016 Apr 1;208:147-9
pubmed: 26859321
Cell. 2015 Sep 24;163(1):123-33
pubmed: 26406374
Food Funct. 2016 Apr;7(4):1788-96
pubmed: 26757793
J Thromb Haemost. 2010 Nov;8(11):2571-4
pubmed: 20831623
Neurobiol Aging. 2014 Sep;35 Suppl 2:S65-73
pubmed: 24916582
Nutr Metab Cardiovasc Dis. 2013 Mar;23(3):257-63
pubmed: 21824756
Transfus Apher Sci. 2015 Oct;53(2):168-72
pubmed: 26542350
Brain Circ. 2017 Apr-Jun;3(2):45-56
pubmed: 30276305
Appl Physiol Nutr Metab. 2016 May;41(5):522-7
pubmed: 26963592
Nutrients. 2020 Jun 12;12(6):
pubmed: 32545505
Ann N Y Acad Sci. 2002 Nov;977:306-14
pubmed: 12480766
Blood. 2008 May 15;111(10):5028-36
pubmed: 18198347
Am J Clin Nutr. 2011 Dec;94(6):1584-91
pubmed: 22071706
J Biol Chem. 1999 Mar 12;274(11):7545-56
pubmed: 10066822
J Nanosci Nanotechnol. 2017 Apr;17(4):2817-823
pubmed: 29668171
Biomed Res Int. 2014;2014:253746
pubmed: 24900959
Blood. 2009 Jan 29;113(5):1112-21
pubmed: 18802008
J Nutr Biochem. 2012 Sep;23(9):1128-33
pubmed: 22137256
Atherosclerosis. 2014 Nov;237(1):208-19
pubmed: 25244505
Blood Transfus. 2011 Apr;9(2):120-38
pubmed: 21084000
Int J Hypertens. 2016;2016:6791519
pubmed: 27088010
Atherosclerosis. 2012 Mar;221(1):226-31
pubmed: 22245039
Lancet Neurol. 2010 Jul;9(7):689-701
pubmed: 20610345
Arterioscler Thromb Vasc Biol. 2016 Mar;36(3):482-90
pubmed: 26821950
J Am Coll Cardiol. 2010 Jul 13;56(3):218-24
pubmed: 20620742
Crit Care. 2019 Jan 17;23(1):16
pubmed: 30654825
Oxid Med Cell Longev. 2020 Sep 26;2020:1496462
pubmed: 33062134
Nutrition. 2013 Jul-Aug;29(7-8):939-47
pubmed: 23473733
Eur J Nutr. 2015 Apr;54(3):421-8
pubmed: 24906470
FASEB J. 2015 Feb;29(2):589-96
pubmed: 25342129
Neurology. 1965 Aug;15:774-84
pubmed: 14315302
Nat Neurosci. 2018 Oct;21(10):1300-1309
pubmed: 30258237
J Geriatr Cardiol. 2017 May;14(5):321-326
pubmed: 28630610
Acta Physiol (Oxf). 2015 Apr;213(4):747-9
pubmed: 25683245
Am J Hypertens. 2014 Jan;27(1):56-64
pubmed: 24014659
J Diabetes. 2015 Mar;7(2):202-12
pubmed: 24893671
Am J Clin Nutr. 2009 May;89(5):1607S-1612S
pubmed: 19321569
J Immunol. 2005 Jun 1;174(11):7268-77
pubmed: 15905573
Stroke. 2010 Aug;41(8):1652-8
pubmed: 20576951
PLoS One. 2013 Oct 24;8(10):e76520
pubmed: 24204633
Psychol Aging. 2010 Jun;25(2):453-63
pubmed: 20545429
J Thromb Thrombolysis. 2014 May;37(4):455-63
pubmed: 24097206
CNS Neurosci Ther. 2013 Dec;19(12):917-25
pubmed: 24267641
J Exp Med. 2003 Jun 2;197(11):1585-98
pubmed: 12782720
J Hypertens. 2016 Nov;34(11):2164-71
pubmed: 27512965
Tumour Biol. 2016 Nov;37(11):14391-14401
pubmed: 27629289
Circ Res. 2015 Jan 30;116(3):531-49
pubmed: 25634975
Neurology. 1982 Aug;32(8):871-6
pubmed: 7048128
Continuum (Minneap Minn). 2020 Apr;26(2):332-352
pubmed: 32224755
Int J Stroke. 2013 Aug;8(6):413-21
pubmed: 22336034
EMBO J. 2009 Apr 22;28(8):1043-54
pubmed: 19300439
J Neuroinflammation. 2013 Jun 19;10:73
pubmed: 23782872
Am J Transplant. 2009 Mar;9(3):550-7
pubmed: 19260834
Circ Res. 2005 Sep 16;97(6):512-23
pubmed: 16166562
J Neuroendocrinol. 2018 Oct;30(10):e12598
pubmed: 29645315
Brain. 2015 Dec;138(Pt 12):3803-15
pubmed: 26490330
J Immunol. 2006 Aug 1;177(3):1975-80
pubmed: 16849511
Neurobiol Aging. 2013 Jul;34(7):1913-20
pubmed: 23414669
Blood. 2005 Feb 15;105(4):1515-22
pubmed: 15486064
Front Immunol. 2018 Apr 13;9:698
pubmed: 29706957
J Gastroenterol Hepatol. 2017 Mar;32 Suppl 1:78-81
pubmed: 28244676
J Extracell Vesicles. 2018 Nov 23;7(1):1535750
pubmed: 30637094
Front Cardiovasc Med. 2019 Sep 11;6:132
pubmed: 31572732
J Pharm Pharm Sci. 2013;16(2):238-53
pubmed: 23958193
Theranostics. 2020 Jul 25;10(21):9512-9527
pubmed: 32863942
BMJ. 2018 Jun 13;361:k2396
pubmed: 29898951
Can J Cardiol. 2018 May;34(5):506-525
pubmed: 29731013
Clin Sci (Lond). 2017 Jun 1;131(11):1059-1068
pubmed: 28515342
Neurology. 2017 Jan 31;88(5):426-432
pubmed: 28031395
Platelets. 2015;26(3):224-9
pubmed: 24749953
Crit Care. 2016 Dec 20;20(1):406
pubmed: 27993148
Neurosci Biobehav Rev. 2018 Jul;90:164-173
pubmed: 29656031
Clin Sci (Lond). 2017 Mar 1;131(5):369-379
pubmed: 28202749
Blood. 2004 Oct 15;104(8):2543-8
pubmed: 15213101
Biochim Biophys Acta. 2016 Mar;1862(3):403-10
pubmed: 26432482
Cell. 2016 Mar 24;165(1):111-124
pubmed: 26972052
Science. 2002 Jun 14;296(5575):1991-5
pubmed: 12065827
Free Radic Biol Med. 2010 Dec 1;49(11):1603-16
pubmed: 20840865
Intern Med. 2018 Jan 15;57(2):189-196
pubmed: 29033410
Nutrition. 2020 Jul - Aug;75-76:110658
pubmed: 32305657
J Cereb Blood Flow Metab. 2015 Mar 31;35(4):648-54
pubmed: 25564234
Neurology. 2014 Sep 30;83(14):1228-34
pubmed: 25165388
Mov Disord. 2015 Mar;30(3):350-8
pubmed: 25476529
Br J Pharmacol. 2012 Feb;165(3):716-28
pubmed: 21745193
Clin Interv Aging. 2015 Oct 23;10:1695-704
pubmed: 26604717
Shock. 2016 Mar;45(3):259-70
pubmed: 26871664
Int J Mol Sci. 2020 Jul 29;21(15):
pubmed: 32751379
Thromb Haemost. 2016 Jul 4;116(1):103-14
pubmed: 27052787
Adv Nutr. 2016 Sep 15;7(5):905-16
pubmed: 27633106
Arterioscler Thromb Vasc Biol. 2011 Jan;31(1):27-33
pubmed: 21160065
Tissue Barriers. 2015 Apr 03;3(1-2):e978720
pubmed: 25838983
Circulation. 2004 Apr 6;109(13):1653-9
pubmed: 15023873
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2011 Oct;19(5):1260-3
pubmed: 22040984
Clin Transl Immunology. 2017 Jan 20;6(1):e125
pubmed: 28197336
J Neurochem. 2002 Jul;82(2):249-57
pubmed: 12124426
Neuron. 2013 Nov 20;80(4):844-66
pubmed: 24267647
Neurology. 2015 Apr 21;84(16):1685-92
pubmed: 25809303
Thromb Haemost. 2007 Mar;97(3):425-34
pubmed: 17334510
Circulation. 2000 Feb 29;101(8):841-3
pubmed: 10694520
Blood Coagul Fibrinolysis. 2017 Jul;28(5):373-382
pubmed: 27926582
Cell Physiol Biochem. 2016;39(6):2439-2450
pubmed: 27832642
Circ Res. 2020 May 8;126(10):1415-1442
pubmed: 32379574
Circulation. 2002 Nov 5;106(19):2442-7
pubmed: 12417540
Cerebrovasc Dis. 2015;39(1):39-52
pubmed: 25547195
Stroke. 2010 Oct;41(10):2353-7
pubmed: 20814009
J Res Med Sci. 2015 Jul;20(7):707-13
pubmed: 26622263
Front Neurol. 2019 Sep 24;10:1020
pubmed: 31616367
Anal Biochem. 2002 Mar 15;302(2):191-8
pubmed: 11878797
Blood. 2014 Mar 13;123(11):1739-46
pubmed: 24408325
Br J Nutr. 2015 Jun 14;113(11):1704-11
pubmed: 25880162
Biol Psychiatry. 2016 Jul 1;80(1):e3-4
pubmed: 26774967
Am J Pathol. 2002 Feb;160(2):673-80
pubmed: 11839588
Thromb Res. 2013 May;131(5):411-7
pubmed: 23347681
Nutrients. 2020 Sep 25;12(10):
pubmed: 32992756
J Thromb Haemost. 2005 Jun;3(6):1301-8
pubmed: 15946221
Eur Heart J. 2011 Aug;32(16):2034-41
pubmed: 21186238
Lancet Neurol. 2019 Jul;18(7):684-696
pubmed: 31097385
Blood. 2007 Oct 1;110(7):2440-8
pubmed: 17536014
Circ J. 2011;75(2):451-6
pubmed: 21157110
FASEB J. 2014 Mar;28(3):1464-73
pubmed: 24302679
Br J Pharmacol. 2017 Nov;174(22):3926-3939
pubmed: 28052311
Am J Clin Nutr. 2014 Jul;100(1):270-7
pubmed: 24808491
Metabol Open. 2020 Aug 01;7:100047
pubmed: 33015602
Thromb Haemost. 2015 Aug 31;114(3):449-58
pubmed: 26293514
BBA Clin. 2015 Aug 03;4:69-75
pubmed: 26674662
Neurosurgery. 1983 Aug;13(2):199-203
pubmed: 6888700
Thromb Haemost. 1996 Mar;75(3):395-400
pubmed: 8701396
Indian J Anaesth. 2014 Sep;58(5):515-23
pubmed: 25535411
Clin Nutr. 2018 Apr;37(2):542-550
pubmed: 28302405
Blood Purif. 2020;49(1-2):143-150
pubmed: 31851980
Neurology. 2008 Aug 5;71(6):439-46
pubmed: 18678827
J Stroke Cerebrovasc Dis. 2017 Dec;26(12):3020-3028
pubmed: 28889932
Cell Transplant. 2018 Dec;27(12):1711-1722
pubmed: 30251566
Science. 2005 May 27;308(5726):1314-8
pubmed: 15831717
Free Radic Res. 2018 Jan;52(1):1-13
pubmed: 29166803
Leukemia. 2006 Sep;20(9):1487-95
pubmed: 16791265
Blood Coagul Fibrinolysis. 2011 Sep;22(6):526-31
pubmed: 21577091
Vascul Pharmacol. 2014 Dec;63(3):118-26
pubmed: 25446165
Clin Exp Pharmacol Physiol. 2017 Feb;44(2):294-304
pubmed: 27778375
Prostaglandins Leukot Essent Fatty Acids. 2018 Sep;136:3-13
pubmed: 28314621
Circulation. 1997 Nov 18;96(10):3534-41
pubmed: 9396452
Int J Mol Sci. 2016 Feb 06;17(2):173
pubmed: 26861304
Nutr Metab Cardiovasc Dis. 2016 Mar;26(3):254-60
pubmed: 26803595
Am J Clin Nutr. 2004 May;79(5):774-9
pubmed: 15113714
J Nutr. 2012 Feb;142(2):334-9
pubmed: 22190025
Mol Neurobiol. 2019 Jul;56(7):5075-5094
pubmed: 30474797
Nutrients. 2018 May 08;10(5):
pubmed: 29738477
Stroke. 2009 May;40(5):1623-6
pubmed: 19286604
Stroke. 2016 Feb;47(2):554-60
pubmed: 26742799
Science. 2017 Aug 11;357(6351):570-575
pubmed: 28798125
Proteomics. 2006 Jan;6(1):153-71
pubmed: 16342139
Metabolism. 2009 May;58(5):675-81
pubmed: 19375591
Circ Res. 2002 Nov 1;91(9):761-8
pubmed: 12411389