Functionalized Scintillating Nanotubes for Simultaneous Radio- and Photodynamic Therapy of Cancer.
nanomaterials
photodynamic therapy
radiotherapy
scintillating nanoparticles
singlet oxygen
Journal
ACS applied materials & interfaces
ISSN: 1944-8252
Titre abrégé: ACS Appl Mater Interfaces
Pays: United States
ID NLM: 101504991
Informations de publication
Date de publication:
24 Mar 2021
24 Mar 2021
Historique:
pubmed:
16
3
2021
medline:
27
7
2021
entrez:
15
3
2021
Statut:
ppublish
Résumé
As a model radio-photodynamic therapy (RPDT) agent, we developed a multicomponent nanomaterial by anchoring conjugated chromophores on the surface of scintillating chrysotile nanotubes. Its ultimate composition makes the system a scintillation-activated photosensitizer for the singlet oxygen production. This nanomaterial shows a remarkable ability to enhance the production of singlet oxygen in an aqueous environment, under X-ray irradiation, boosting its production by almost 1 order of magnitude. Its efficiency as a coadjutant for radiotherapy has been tested
Identifiants
pubmed: 33719410
doi: 10.1021/acsami.1c02504
pmc: PMC8153399
doi:
Substances chimiques
Asbestos, Serpentine
0
Photosensitizing Agents
0
Singlet Oxygen
17778-80-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
12997-13008Références
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