Corneal biomechanical parameters in systemic autoimmune diseases.
Ankylosing spondylitis
CORVIS ST
corneal biomechanics
rheumatoid arthritis
Journal
Clinical & experimental optometry
ISSN: 1444-0938
Titre abrégé: Clin Exp Optom
Pays: United States
ID NLM: 8703442
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
pubmed:
16
3
2021
medline:
7
4
2022
entrez:
15
3
2021
Statut:
ppublish
Résumé
The relationship between the cornea and systemic autoimmune diseases has been demonstrated in prior studies. Corneal Visualisation Scheimpflug Technology (Corvis ST) provides a specific and detailed assessment of corneal biomechanical features, such as stiffness and elasticity. This study aims to evaluate corneal biomechanical changes in patients with systemic autoimmune diseases using Corvis ST. This prospective study included 36 patients with ankylosing spondylitis (AS), 38 patients with rheumatoid arthritis (RA), and 36 age- and sex-matched healthy subjects. After ophthalmologic examinations Pentacam HR and Corvis ST was performed on all eyes. The mean keratometric and pachymetric data, corneal biomechanical parameters, biomechanical intraocular pressure (bIOP) were analysed. There was no statistically significant differences among the groups regarding age, gender, refraction, visual acuity, IOP, pachymetry and keratometry. Compared to healthy controls, the mean velocity values of applanation 1 (A1V) and 2 (A2V), deformation amplitude (DA), and corvis biomechanical index (CBI) were statistically significantly higher and stiffness parameter at first applanation (SPA1) was statistically significantly lower in AS and RA patients (all p < 0.05). In both AS and RA groups, disease duration was found to be negatively correlated with SPA1 (p = 0.043, 0.027, respectively) and positively correlated with CBI (p = 0.022, 0.020, respectively). AS and RA patients have a decreased corneal stiffness compared to healthy subjects. Disease duration seems to be correlated with these changes.
Sections du résumé
CLINICAL RELEVANCE
CONCLUSIONS
The relationship between the cornea and systemic autoimmune diseases has been demonstrated in prior studies. Corneal Visualisation Scheimpflug Technology (Corvis ST) provides a specific and detailed assessment of corneal biomechanical features, such as stiffness and elasticity.
BACKGROUND
BACKGROUND
This study aims to evaluate corneal biomechanical changes in patients with systemic autoimmune diseases using Corvis ST.
METHODS
METHODS
This prospective study included 36 patients with ankylosing spondylitis (AS), 38 patients with rheumatoid arthritis (RA), and 36 age- and sex-matched healthy subjects. After ophthalmologic examinations Pentacam HR and Corvis ST was performed on all eyes. The mean keratometric and pachymetric data, corneal biomechanical parameters, biomechanical intraocular pressure (bIOP) were analysed.
RESULTS
RESULTS
There was no statistically significant differences among the groups regarding age, gender, refraction, visual acuity, IOP, pachymetry and keratometry. Compared to healthy controls, the mean velocity values of applanation 1 (A1V) and 2 (A2V), deformation amplitude (DA), and corvis biomechanical index (CBI) were statistically significantly higher and stiffness parameter at first applanation (SPA1) was statistically significantly lower in AS and RA patients (all p < 0.05). In both AS and RA groups, disease duration was found to be negatively correlated with SPA1 (p = 0.043, 0.027, respectively) and positively correlated with CBI (p = 0.022, 0.020, respectively).
CONCLUSION
CONCLUSIONS
AS and RA patients have a decreased corneal stiffness compared to healthy subjects. Disease duration seems to be correlated with these changes.
Identifiants
pubmed: 33719873
doi: 10.1080/08164622.2021.1896335
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM