Ciliary Rootlet Coiled-Coil 2 (crocc2) Is Associated with Evolutionary Divergence and Plasticity of Cichlid Jaw Shape.
cilia
craniofacial
eco-devo
mechanosensing
phenotypic plasticity
Journal
Molecular biology and evolution
ISSN: 1537-1719
Titre abrégé: Mol Biol Evol
Pays: United States
ID NLM: 8501455
Informations de publication
Date de publication:
29 07 2021
29 07 2021
Historique:
pubmed:
16
3
2021
medline:
21
9
2021
entrez:
15
3
2021
Statut:
ppublish
Résumé
Cichlid fishes exhibit rapid, extensive, and replicative adaptive radiation in feeding morphology. Plasticity of the cichlid jaw has also been well documented, and this combination of iterative evolution and developmental plasticity has led to the proposition that the cichlid feeding apparatus represents a morphological "flexible stem." Under this scenario, the fixation of environmentally sensitive genetic variation drives evolutionary divergence along a phenotypic axis established by the initial plastic response. Thus, if plasticity is predictable then so too should be the evolutionary response. We set out to explore these ideas at the molecular level by identifying genes that underlie both the evolution and plasticity of the cichlid jaw. As a first step, we fine-mapped an environment-specific quantitative trait loci for lower jaw shape in cichlids, and identified a nonsynonymous mutation in the ciliary rootlet coiled-coil 2 (crocc2), which encodes a major structural component of the primary cilium. Given that primary cilia play key roles in skeletal mechanosensing, we reasoned that this gene may confer its effects by regulating the sensitivity of bone to respond to mechanical input. Using both cichlids and zebrafish, we confirmed this prediction through a series of experiments targeting multiple levels of biological organization. Taken together, our results implicate crocc2 as a novel mediator of bone formation, plasticity, and evolution.
Identifiants
pubmed: 33720362
pii: 6171153
doi: 10.1093/molbev/msab071
pmc: PMC8321518
doi:
Substances chimiques
Cytoskeletal Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
3078-3092Subventions
Organisme : NIDCR NIH HHS
ID : R01 DE026446
Pays : United States
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.
Références
Ann N Y Acad Sci. 2009 Jun;1168:218-28
pubmed: 19566710
Nat Rev Genet. 2008 Jan;9(1):75-82
pubmed: 18059367
Mol Ecol. 2021 Feb;30(3):761-774
pubmed: 33278044
Evol Dev. 2007 Jul-Aug;9(4):393-401
pubmed: 17651363
Ann Bot. 2016 Apr;117(5):769-79
pubmed: 26359425
Proc Natl Acad Sci U S A. 2020 Aug 11;117(32):19321-19327
pubmed: 32719137
Nat Commun. 2018 Aug 8;9(1):3159
pubmed: 30089797
J Cell Sci. 2012 Apr 15;125(Pt 8):1945-57
pubmed: 22357948
Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16287-92
pubmed: 16251275
J Morphol. 2010 Jul;271(7):814-25
pubmed: 20235155
Evolution. 2007 Dec;61(12):2743-9
pubmed: 17924956
Proc Biol Sci. 2017 Aug 16;284(1860):
pubmed: 28768892
Integr Comp Biol. 2004 Nov;44(5):378-89
pubmed: 21676723
Nat Rev Rheumatol. 2015 Sep;11(9):552-60
pubmed: 26077918
Bone. 2013 Jun;54(2):196-204
pubmed: 23201223
Curr Biol. 2009 Jul 14;19(13):R526-35
pubmed: 19602418
Evolution. 2006 Apr;60(4):801-13
pubmed: 16739461
Dev Biol. 2007 Jun 15;306(2):505-15
pubmed: 17448458
BMC Genomics. 2011 Jan 04;12:4
pubmed: 21205322
PLoS One. 2010 Mar 08;5(3):e9551
pubmed: 20221400
Proc Natl Acad Sci U S A. 2005 May 3;102 Suppl 1:6543-9
pubmed: 15851679
Trends Ecol Evol. 1993 Jan;8(1):31-4
pubmed: 21236096
Nat Commun. 2014 Apr 03;5:3629
pubmed: 24699776
J Biol Chem. 2006 Oct 13;281(41):30884-95
pubmed: 16905538
Nature. 2014 Oct 9;514(7521):161-4
pubmed: 25297418
Trends Ecol Evol. 2005 Sep;20(9):481-6
pubmed: 16701424
Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):8989-94
pubmed: 16754880
Nature. 1959 Jun 13;183(4676):1654-5
pubmed: 13666847
Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5252-7
pubmed: 12704237
Nat Rev Mol Cell Biol. 2011 Dec 22;13(1):27-38
pubmed: 22189423
Ann N Y Acad Sci. 2015 Jan;1335:78-99
pubmed: 24961486
Bioessays. 2008 May;30(5):432-47
pubmed: 18404691
Mol Ecol. 2014 Nov;23(21):5135-50
pubmed: 25156298
J Evol Biol. 2007 Mar;20(2):673-84
pubmed: 17305833
Mol Biol Evol. 2014 Dec;31(12):3113-24
pubmed: 25234704
Evol Dev. 2013 Nov-Dec;15(6):426-41
pubmed: 24261444
Proc Biol Sci. 2010 Nov 7;277(1698):3327-33
pubmed: 20534620
Adv Protein Chem. 2005;70:79-112
pubmed: 15837514
Mol Ecol. 2016 Dec;25(24):6012-6023
pubmed: 27516345
PLoS One. 2012;7(3):e33368
pubmed: 22428034
Dev Genes Evol. 2017 Sep;227(5):297-307
pubmed: 28780641
Trends Ecol Evol. 1995 May;10(5):212-7
pubmed: 21237012
Trends Ecol Evol. 2010 Aug;25(8):459-67
pubmed: 20557976
Proc Biol Sci. 2003 Jul 22;270(1523):1433-40
pubmed: 12965006
PLoS Genet. 2005 Oct;1(4):e53
pubmed: 16254602
Proc Biol Sci. 2012 May 7;279(1734):1797-805
pubmed: 22113035
Evolution. 2014 May;68(5):1436-49
pubmed: 24433457
Mol Ecol. 2017 Jan;26(1):330-350
pubmed: 27747962
Evolution. 2012 Nov;66(11):3352-66
pubmed: 23106702
PLoS One. 2013 Apr 04;8(4):e61298
pubmed: 23593456
Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13194-9
pubmed: 21788496
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
J Evol Biol. 2014 Nov;27(11):2431-42
pubmed: 25302771
Heredity (Edinb). 2015 Oct;115(4):357-65
pubmed: 25204302
J Exp Zool B Mol Dev Evol. 2007 Sep 15;308(5):625-41
pubmed: 17358013
J Cell Biol. 2002 Nov 11;159(3):431-40
pubmed: 12427867
Trends Mol Med. 2009 May;15(5):208-16
pubmed: 19362057
Curr Biol. 2013 Oct 21;23(20):2016-22
pubmed: 24094853
Mol Cell Biol. 2005 May;25(10):4129-37
pubmed: 15870283
Curr Protoc Hum Genet. 2013 Jan;Chapter 7:Unit7.20
pubmed: 23315928
Methods Cell Biol. 2009;94:199-222
pubmed: 20362092
Mol Ecol. 2017 Dec;26(23):6634-6653
pubmed: 29098748
Bioessays. 2010 Jul;32(7):553-8
pubmed: 20544734
Am Nat. 2008 Oct;172(4):449-62
pubmed: 18729721