Leukocyte telomere length is inversely associated with a metabolic risk score in Mesoamerican children.
Journal
American journal of human biology : the official journal of the Human Biology Council
ISSN: 1520-6300
Titre abrégé: Am J Hum Biol
Pays: United States
ID NLM: 8915029
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
revised:
23
02
2021
received:
25
09
2020
accepted:
27
02
2021
pubmed:
16
3
2021
medline:
3
2
2022
entrez:
15
3
2021
Statut:
ppublish
Résumé
Leukocyte telomere length (LTL) may be involved in the etiology of the metabolic syndrome (MetS). We examined the associations of LTL with MetS and its components among Mesoamerican children and their adult parents, in a region where MetS prevalence is high. We conducted a cross-sectional study of 151 children aged 7-12 years and 346 parents from the capitals of Belize, Honduras, Nicaragua, Costa Rica, Panama, and Chiapas State, Mexico. We quantified LTL by qPCR on DNA extracted from whole blood. In children, we created an age- and sex-standardized metabolic risk score using waist circumference (WC), the homeostasis model of insulin resistance (HOMA-IR), blood pressure, serum high-density lipoprotein (HDL) cholesterol, and serum triglycerides. In adults, MetS was defined according to the National Cholesterol Education Program's Adult Treatment Panel III definition. We estimated mean differences in metabolic risk score and prevalence ratios of MetS across quartiles of LTL using multivariable-adjusted linear and Poisson regression models, respectively. In children, every 1 LTL z-score was related to an adjusted 0.05 units lower (95% CI: -0.09, -0.02, P = 0.005) MetS risk score, through WC, HOMA-IR, and HDL. Among adults, LTL was not associated with MetS prevalence; however, every 1 LTL z-score was associated with an adjusted 34% lower prevalence of high fasting glucose (95% CI: 3%, 55%, p = .03). Among Mesoamerican children, LTL is associated with an improved metabolic profile; among adults, LTL is inversely associated with the prevalence of high fasting glucose.
Substances chimiques
Blood Glucose
0
Triglycerides
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e23596Subventions
Organisme : NHLBI NIH HHS
ID : HHSN268200900028C
Pays : United States
Informations de copyright
© 2021 Wiley Periodicals LLC.
Références
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