The association between genetically determined ABO blood types and major depressive disorder.
Association study
Blood group
Blood type
Depression
MDD
PGC
Psychiatric disorders
Journal
Psychiatry research
ISSN: 1872-7123
Titre abrégé: Psychiatry Res
Pays: Ireland
ID NLM: 7911385
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
21
10
2020
accepted:
21
02
2021
pubmed:
16
3
2021
medline:
26
8
2021
entrez:
15
3
2021
Statut:
ppublish
Résumé
ABO blood types and their corresponding antigens have long been assumed to be related to different human diseases. So far, smaller studies on the relationship between mental disorders and blood types yielded contradicting results. In this study we analyzed the association between ABO blood types and lifetime major depressive disorder (MDD). We performed a pooled analysis with data from 26 cohorts that are part of the MDD working group of the Psychiatric Genomics Consortium (PGC). The dataset included 37,208 individuals of largely European ancestry of which 41.6% were diagnosed with lifetime MDD. ABO blood types were identified using three single nucleotide polymorphisms in the ABO gene: rs505922, rs8176746 and rs8176747. Regression analyses were performed to assess associations between the individual ABO blood types and MDD diagnosis as well as putative interaction effects with sex. The models were adjusted for sex, cohort and the first ten genetic principal components. The percentage of blood type A was slightly lower in cases than controls while blood type O was more prominent in cases. However, these differences were not statistically significant. Our analyses found no evidence of an association between ABO blood types and major depressive disorder.
Identifiants
pubmed: 33721783
pii: S0165-1781(21)00134-7
doi: 10.1016/j.psychres.2021.113837
pmc: PMC8071927
mid: NIHMS1683126
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
113837Subventions
Organisme : NIMH NIH HHS
ID : U01 MH109528
Pays : United States
Informations de copyright
Copyright © 2021. Published by Elsevier B.V.
Références
Arterioscler Thromb Vasc Biol. 2020 Mar;40(3):830-838
pubmed: 31969017
Asian Pac J Cancer Prev. 2019 Mar 26;20(3):789-793
pubmed: 30909687
Wiley Interdiscip Rev Syst Biol Med. 2016 Nov;8(6):517-535
pubmed: 27599872
BMC Bioinformatics. 2020 Jan 10;21(1):14
pubmed: 31924160
Nature. 2015 Oct 1;526(7571):68-74
pubmed: 26432245
Ann Intern Med. 1978 Mar;88(3):424-6
pubmed: 629506
Bioinformatics. 2015 Nov 1;31(21):3555-7
pubmed: 26139635
Nature. 1990 May 17;345(6272):229-33
pubmed: 2333095
Nat Genet. 2018 May;50(5):668-681
pubmed: 29700475
Blood Transfus. 2019 Jan;17(1):66-71
pubmed: 29517969
Psychol Rep. 2001 Jun;88(3 Pt 1):725-6
pubmed: 11508010
Psychol Bull. 2017 Aug;143(8):783-822
pubmed: 28447828