Prevalence of SARS-CoV-2 antibodies in pediatric healthcare workers.
Adult
Antibodies, Viral
/ blood
COVID-19
/ diagnosis
COVID-19 Serological Testing
/ methods
Child
Emergency Service, Hospital
Female
Health Personnel
/ statistics & numerical data
Humans
Immunoglobulin G
/ blood
Male
Pandemics
Pediatrics
Personal Protective Equipment
Prevalence
Prospective Studies
Risk Factors
SARS-CoV-2
/ immunology
Anti-SARS-CoV-2-IgG Antibodies
COVID-19
Emergency Department
Personal Protective Equipment (PPE)
SARS-CoV-2
healthcare workers
Journal
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
ISSN: 1878-3511
Titre abrégé: Int J Infect Dis
Pays: Canada
ID NLM: 9610933
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
17
01
2021
revised:
28
02
2021
accepted:
08
03
2021
pubmed:
17
3
2021
medline:
21
5
2021
entrez:
16
3
2021
Statut:
ppublish
Résumé
To determine SARS-CoV-2-antibody prevalence in pediatric healthcare workers (pHCWs). Baseline prevalence of anti-SARS-CoV-2-IgG was assessed in a prospective cohort study from a large pediatric healthcare facility. Prior SARS-CoV-2 testing history, potential risk factors and anxiety level about COVID-19 were determined. Prevalence difference between emergency department (ED)-based and non-ED-pHCWs was modeled controlling for those covariates. Chi-square test-for-trend was used to examine prevalence by month of enrollment. Most of 642 pHCWs enrolled were 31-40years, female and had no comorbidities. Half had children in their home, 49% had traveled, 42% reported an illness since January, 31% had a known COVID-19 exposure, and 8% had SARS-CoV-2 PCR testing. High COVID-19 pandemic anxiety was reported by 71%. Anti-SARS-CoV-2-IgG prevalence was 4.1%; 8.4% among ED versus 2.0% among non-ED pHCWs (p < 0.001). ED-work location and known COVID-19 exposure were independent risk factors. 31% of antibody-positive pHCWs reported no symptoms. Prevalence significantly (p < 0.001) increased from 3.0% in April-June to 12.7% in July-August. Anti-SARS-CoV-2-IgG prevalence was low in pHCWs but increased rapidly over time. Both working in the ED and exposure to a COVID-19-positive contact were associated with antibody-seropositivity. Ongoing universal PPE utilization is essential. These data may guide vaccination policies to protect front-line workers.
Identifiants
pubmed: 33722686
pii: S1201-9712(21)00234-4
doi: 10.1016/j.ijid.2021.03.017
pmc: PMC7952267
pii:
doi:
Substances chimiques
Antibodies, Viral
0
Immunoglobulin G
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
474-481Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.
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