Musashi-2 (MSI2) regulates epidermal growth factor receptor (EGFR) expression and response to EGFR inhibitors in EGFR-mutated non-small cell lung cancer (NSCLC).
Journal
Oncogenesis
ISSN: 2157-9024
Titre abrégé: Oncogenesis
Pays: United States
ID NLM: 101580004
Informations de publication
Date de publication:
15 Mar 2021
15 Mar 2021
Historique:
received:
21
01
2021
accepted:
19
02
2021
revised:
04
02
2021
entrez:
16
3
2021
pubmed:
17
3
2021
medline:
17
3
2021
Statut:
epublish
Résumé
Non-small cell lung cancer (NSCLC) has limited treatment options. Expression of the RNA-binding protein (RBP) Musashi-2 (MSI2) is elevated in a subset of non-small cell lung cancer (NSCLC) tumors upon progression, and drives NSCLC metastasis. We evaluated the mechanism of MSI2 action in NSCLC to gain therapeutically useful insights. Reverse phase protein array (RPPA) analysis of MSI2-depleted versus control Kras
Identifiants
pubmed: 33723247
doi: 10.1038/s41389-021-00317-y
pii: 10.1038/s41389-021-00317-y
pmc: PMC7961039
doi:
Types de publication
Journal Article
Langues
eng
Pagination
29Subventions
Organisme : NCI NIH HHS
ID : R03 CA216173
Pays : United States
Organisme : NIDCR NIH HHS
ID : P50 DE030707
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA218802
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA223394
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA006927
Pays : United States
Organisme : NCI NIH HHS
ID : R50 CA221675
Pays : United States
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