Alkyne-Bridged α-Conotoxin Vc1.1 Potently Reverses Mechanical Allodynia in Neuropathic Pain Models.

Alkynes / chemistry Analgesics / chemistry Animals Cells, Cultured Conotoxins / chemistry Conus Snail / chemistry Disease Models, Animal Female HEK293 Cells Humans Hyperalgesia / drug therapy Male Models, Molecular Neuralgia / drug therapy Rats, Sprague-Dawley Xenopus

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
25 03 2021
Historique:
pubmed: 17 3 2021
medline: 5 6 2021
entrez: 16 3 2021
Statut: ppublish

Résumé

Several

Identifiants

DOI: 10.1021/acs.jmedchem.0c02151 PMID: 33724033
pubmed: 33724033
doi: 10.1021/acs.jmedchem.0c02151
doi:

Substances chimiques

Alkynes 0
Analgesics 0
Conotoxins 0
alpha-conotoxin Vc1.1 5U5J1KR8NU

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3222-3233

Auteurs

Alessia Belgi (A)

School of Chemistry, Monash University, Clayton, Victoria 3800, Australia.

James V Burnley (JV)

School of Chemistry, Monash University, Clayton, Victoria 3800, Australia.

Christopher A MacRaild (CA)

Medicinal Chemistry, Monash Institute of Pharmaceutical Science, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.
ORCID: 0000-0002-3694-3989

Sandeep Chhabra (S)

Medicinal Chemistry, Monash Institute of Pharmaceutical Science, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.

Khaled A Elnahriry (KA)

Medicinal Chemistry, Monash Institute of Pharmaceutical Science, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.

Samuel D Robinson (SD)

Medicinal Chemistry, Monash Institute of Pharmaceutical Science, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.

Simon G Gooding (SG)

School of Chemistry, Monash University, Clayton, Victoria 3800, Australia.

Han-Shen Tae (HS)

Illawarra Health & Medical Research Institute (IHMRI), University of Wollongong, Wollongong, New South Wales 2522, Australia.
ORCID: 0000-0001-8961-7194

Peter Bartels (P)

Illawarra Health & Medical Research Institute (IHMRI), University of Wollongong, Wollongong, New South Wales 2522, Australia.

Mahsa Sadeghi (M)

Illawarra Health & Medical Research Institute (IHMRI), University of Wollongong, Wollongong, New South Wales 2522, Australia.

Fei-Yue Zhao (FY)

NeuroSolutions Ltd., Coventry CV4 7AL, U.K.

Haifeng Wei (H)

NeuroSolutions Ltd., Coventry CV4 7AL, U.K.

David Spanswick (D)

NeuroSolutions Ltd., Coventry CV4 7AL, U.K.
Biomedicine Discovery Institute and the Department of Physiology, Monash University, Clayton, Victoria 3800, Australia.
Warwick Medical School, University of Warwick, Coventry CV4 7AL, U.K.

David J Adams (DJ)

Illawarra Health & Medical Research Institute (IHMRI), University of Wollongong, Wollongong, New South Wales 2522, Australia.
ORCID: 0000-0002-7030-2288

Raymond S Norton (RS)

Medicinal Chemistry, Monash Institute of Pharmaceutical Science, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.
ARC Centre for Fragment-Based Design, Monash University, Parkville, Victoria 3052, Australia.
ORCID: 0000-0001-8893-0584

Andrea J Robinson (AJ)

School of Chemistry, Monash University, Clayton, Victoria 3800, Australia.
ORCID: 0000-0003-3859-1312

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures acycliques › Alcynes › Alkyne-Bridged α-Conotoxin Vc1.1 Potently...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Analgésiques › Alkyne-Bridged α-Conotoxin Vc1.1 Potently...
questionsmedicales.fr › Eucaryotes › Animaux › Alkyne-Bridged α-Conotoxin Vc1.1 Potently...
questionsmedicales.fr › Cellules › Cellules cultivées › Alkyne-Bridged α-Conotoxin Vc1.1 Potently...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Venins › Venins de mollusque › Conotoxines › Alkyne-Bridged α-Conotoxin Vc1.1 Potently...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Mollusca › Gastropoda › Conus › Alkyne-Bridged α-Conotoxin Vc1.1 Potently...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Alkyne-Bridged α-Conotoxin Vc1.1 Potently...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Alkyne-Bridged α-Conotoxin Vc1.1 Potently...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Alkyne-Bridged α-Conotoxin Vc1.1 Potently...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Troubles sensitifs › Troubles somatosensoriels › Hyperalgésie › Alkyne-Bridged α-Conotoxin Vc1.1 Potently...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Alkyne-Bridged α-Conotoxin Vc1.1 Potently...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Névralgie › Alkyne-Bridged α-Conotoxin Vc1.1 Potently...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Alkyne-Bridged α-Conotoxin Vc1.1 Potently...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Amphibiens › Anura › Pipidae › Xenopus › Alkyne-Bridged α-Conotoxin Vc1.1 Potently...