The regulatory role of insulin in energy metabolism and leukocyte functions.
insulin
insulin resistance
insulin signaling
leukocytes
Journal
Journal of leukocyte biology
ISSN: 1938-3673
Titre abrégé: J Leukoc Biol
Pays: England
ID NLM: 8405628
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
revised:
08
02
2021
received:
21
12
2020
accepted:
10
02
2021
pubmed:
17
3
2021
medline:
8
2
2022
entrez:
16
3
2021
Statut:
ppublish
Résumé
Insulin is the hormone responsible for maintaining glucose homeostasis in the body, in addition to participating in lipid metabolism, protein synthesis, and the inhibition of gluconeogenesis. These functions are well characterized in the classic organ target cells that are responsible for general energy regulation: the liver, skeletal muscle, and adipose tissue. However, these actions are not restricted to these tissues because insulin has been shown to affect most cells in the body. This review describes the role of insulin in leukocyte signaling pathways, metabolism and functions, and how insulin resistance could affect this signaling and deteriorate leukocyte metabolism and function, in addition to showing evidence that suggests leukocytes may substantially contribute to the development of systemic insulin resistance.
Identifiants
pubmed: 33724523
doi: 10.1002/JLB.2RU1220-847R
pmc: PMC9291603
doi:
Substances chimiques
Insulin
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
197-208Informations de copyright
© 2021 The Authors. Journal of Leukocyte Biology published by Wiley Periodicals LLC on behalf of Society for Leukocyte Biology.
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