Risk factors of BK viral hemorrhagic cystitis in allogenic hematopoietic stem cell transplantation.
BK virus hemorrhagic cystitis
allogenic hematopoietic stem cell transplant
alternative donors
cyclophosphamide
Journal
Transplant infectious disease : an official journal of the Transplantation Society
ISSN: 1399-3062
Titre abrégé: Transpl Infect Dis
Pays: Denmark
ID NLM: 100883688
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
revised:
01
02
2021
received:
06
10
2020
accepted:
08
02
2021
pubmed:
17
3
2021
medline:
3
11
2021
entrez:
16
3
2021
Statut:
ppublish
Résumé
Reactivation of BK virus (BKV) can occur during intensive immunosuppression such as in allogenic hematopoietic stem cell transplant (AHSCT) recipients for whom a systematic PCR urine test for BKV will be positive in 50% to 100% of patients. Only 5% to 40% will develop BKV hemorrhagic cystitis (HC). Thus, BKV PCR testing is useful to confirm a diagnosis of BKV-HC but not to predict its occurrence. The aim of this retrospective study was to ascertain the risk factors of developing BKV HC, mostly in patients receiving posttransplant cyclophosphamide. The study looked at data from Grenoble Alpes University Hospital included in the national retrospective register ProMISe, administered by the "Société Francophone de Greffe de Moelle et de Thérapie Cellulaire". Urine BKV PCR was performed when patients presented grade ≥ 2 hematuria with clinical symptoms of cystitis. BKV-HC was defined as an association of clinical symptoms of cystitis, grade ≥ 2 hematuria and BKV viruria > 7 log
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13601Informations de copyright
© 2021 Wiley Periodicals LLC.
Références
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