Radial Glial Cells: New Views on Old Questions.
Cortical development
GFAP
Neural stem cells
Neurogenesis
Radial glia
Ventricular zone
Journal
Neurochemical research
ISSN: 1573-6903
Titre abrégé: Neurochem Res
Pays: United States
ID NLM: 7613461
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
04
02
2021
accepted:
02
03
2021
revised:
26
02
2021
pubmed:
17
3
2021
medline:
11
1
2022
entrez:
16
3
2021
Statut:
ppublish
Résumé
Radial glial cells (RGC) are at the center of brain development in vertebrates, acting as progenitors for neurons and macroglia (oligodendrocytes and astrocytes) and as guides for migration of neurons from the ventricular surface to their final positions in the brain. These cells originate from neuroepithelial cells (NEC) from which they inherit their epithelial features and polarized morphology, with processes extending from the ventricular to the pial surface of the embryonic cerebrum. We have learnt a great deal since the first descriptions of these cells at the end of the nineteenth century. However, there are still questions regarding how and when NEC transform into RGC or about the function of intermediate filaments such as glial fibrillary acidic protein (GFAP) in RGCs and their dynamics during neurogenesis. For example, it is not clear why RGCs in primates, including humans, express GFAP at the onset of cortical neurogenesis while in rodents it is expressed when it is essentially complete. Based on an ultrastructural analysis of GFAP expression and cell morphology of dividing progenitors in the developing neocortex of the macaque monkey, we show that RGCs become the main progenitor in the developing cerebrum by the start of neurogenesis, as all dividing cells show glial features such as GFAP expression and lack of tight junctions. Also, our data suggest that RGCs retract their apical process during mitosis. We discuss our findings in the context of the role and molecular characteristics of RGCs in the vertebrate brain, their differences with NECs and their dynamic behavior during the process of neurogenesis.
Identifiants
pubmed: 33725233
doi: 10.1007/s11064-021-03296-z
pii: 10.1007/s11064-021-03296-z
pmc: PMC8855517
mid: NIHMS1771372
doi:
Substances chimiques
Glial Fibrillary Acidic Protein
0
Nerve Tissue Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2512-2524Subventions
Organisme : NIDA NIH HHS
ID : R01 DA023999
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH113257
Pays : United States
Organisme : NIDA NIH HHS
ID : R37 DA023999
Pays : United States
Organisme : NIDA NIH HHS
ID : DA023999
Pays : United States
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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