Microheater-integrated zinc oxide nanowire microfluidic device for hybridization-based detection of target single-stranded DNA.

Biosensing Techniques Cell-Free Nucleic Acids / analysis DNA Probes / chemistry DNA, Single-Stranded / analysis Humans Lab-On-A-Chip Devices Limit of Detection Liquid Biopsy / methods Nanowires / chemistry Nucleic Acid Hybridization / methods Zinc Oxide / chemistry
DNA hybridization ZnO nanowires cell-free DNA microfluidics microheater

Journal

Nanotechnology
ISSN: 1361-6528
Titre abrégé: Nanotechnology
Pays: England
ID NLM: 101241272

Informations de publication

Date de publication:
01 Apr 2021
Historique:
received: 08 02 2021
accepted: 16 03 2021
pubmed: 17 3 2021
medline: 23 11 2021
entrez: 16 3 2021
Statut: epublish

Résumé

Detection of cell-free DNA (cfDNA) has an impact on DNA analysis in liquid biopsies. However, current strategies to detect cfDNA have limitations that should be overcome, such as having low sensitivity and requiring much time and a specialized instrument. Thus, non-invasive and rapid detection tools are needed for disease prevention and early-stage treatment. Here we developed a device having a microheater integrated with zinc oxide nanowires (microheater-ZnO-NWs) to detect target single-stranded DNAs (ssDNAs) based on DNA probe hybridization. We confirmed experimentally that our device realized

Identifiants

DOI: 10.1088/1361-6528/abef2c PMID: 33725670
pubmed: 33725670
doi: 10.1088/1361-6528/abef2c
doi:

Substances chimiques

Cell-Free Nucleic Acids 0
DNA Probes 0
DNA, Single-Stranded 0
Zinc Oxide SOI2LOH54Z

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2021 IOP Publishing Ltd.

Auteurs

Hiromi Takahashi (H)

Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, Nagoya, Japan.
ORCID: 0000-0002-2052-726X

Takao Yasui (T)

Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, Nagoya, Japan.
Japan Science and Technology Agency (JST), Saitama, Japan.
Institute of Nano-Life-Systems, Institutes of Innovation for Future Society, Nagoya University, Nagoya, Japan.

Hiromu Kashida (H)

Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, Nagoya, Japan.

Koki Makino (K)

Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, Nagoya, Japan.

Keiko Shinjo (K)

Division of Cancer Biology, Graduate School of Medicine, Nagoya University, Nagoya, Japan.

Quanli Liu (Q)

Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, Nagoya, Japan.

Taisuke Shimada (T)

Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, Nagoya, Japan.

Sakon Rahong (S)

College of Nanotechnology, King Mongkut's Institute of Technology Ladkrabang, Bangkok, Thailand.

Noritada Kaji (N)

Japan Science and Technology Agency (JST), Saitama, Japan.
Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, Kyushu, Japan.

Hiroyuki Asanuma (H)

Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, Nagoya, Japan.

Yoshinobu Baba (Y)

Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, Nagoya, Japan.
Japan Science and Technology Agency (JST), Saitama, Japan.
Institute of Quantum Life Science, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Techniques de biocapteur › Microheater-integrated zinc oxide nanowire...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › Acides nucléiques acellulaires › Microheater-integrated zinc oxide nanowire...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Sondes moléculaires › Sondes d'acide nucléique › Sondes d'ADN › Microheater-integrated zinc oxide nanowire...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Conformation d'acide nucléique › ADN simple brin › Microheater-integrated zinc oxide nanowire...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Microheater-integrated zinc oxide nanowire...
questionsmedicales.fr › Équipement et fournitures › Équipement et fournitures électriques › Laboratoires sur puces › Microheater-integrated zinc oxide nanowire...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Sensibilité et spécificité › Limite de détection › Microheater-integrated zinc oxide nanowire...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Cytodiagnostic › Biopsie › Biopsie liquide › Microheater-integrated zinc oxide nanowire...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanofils › Microheater-integrated zinc oxide nanowire...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Hybridation d'acides nucléiques › Microheater-integrated zinc oxide nanowire...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du zinc › Oxyde de zinc › Microheater-integrated zinc oxide nanowire...