Cisplatin-induced activation and functional modulation of satellite glial cells lead to cytokine-mediated modulation of sensory neuron excitability.
Cisplatin
Cytokines
Dorsal root ganglion
Painful polyneuropathy
Satellite glial cells
Sensory neurons
Journal
Experimental neurology
ISSN: 1090-2430
Titre abrégé: Exp Neurol
Pays: United States
ID NLM: 0370712
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
03
09
2020
revised:
01
02
2021
accepted:
11
03
2021
pubmed:
18
3
2021
medline:
5
10
2021
entrez:
17
3
2021
Statut:
ppublish
Résumé
Cisplatin plays an essential role in the treatment of various cancers. Cisplatin exhibits high efficacy, but it often leads to severe neurotoxic side effects, such as chemotherapy-induced polyneuropathy (CIPN). The pathophysiology of CIPN is not fully understood. There is increasing evidence for damage to satellite glial cells (SGC) and dorsal root ganglion (DRG) neurons. We investigated the influence of cisplatin on the function of SGCs and the direct influence on DRGs. Satellite glial cells were isolated from DRG and exposed to 0.1, 1, 10, or 100 μM cisplatin for 2 h, 4 h, and 24 h. Using immunocytochemical staining and Western blot analysis, the expression of the glial fibrillary acid protein (GFAP), reactive oxygen species (ROS), and inward rectifier potassium channel 4.1 (K
Identifiants
pubmed: 33727094
pii: S0014-4886(21)00100-X
doi: 10.1016/j.expneurol.2021.113695
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Cytokines
0
Reactive Oxygen Species
0
Cisplatin
Q20Q21Q62J
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
113695Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.