Critical ACE2 Determinants of SARS-CoV-2 and Group 2B Coronavirus Infection and Replication.
Amino Acid Sequence
Angiotensin-Converting Enzyme 2
/ chemistry
Animals
Betacoronavirus
/ metabolism
Binding Sites
COVID-19
/ virology
Cell Line
Coronavirus Infections
/ virology
Host Specificity
Humans
Mice
Models, Molecular
Mutation
Protein Binding
Recombinant Proteins
/ chemistry
SARS-CoV-2
/ metabolism
Spike Glycoprotein, Coronavirus
/ chemistry
Virus Replication
COVID-19
SARS-CoV-2
coronavirus
host range
receptors
virus-host interactions
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
16 03 2021
16 03 2021
Historique:
entrez:
17
3
2021
pubmed:
18
3
2021
medline:
2
4
2021
Statut:
epublish
Résumé
The angiotensin-converting enzyme 2 (ACE2) receptor is a major severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) host range determinant, and understanding SARS-CoV-2-ACE2 interactions will provide important insights into COVID-19 pathogenesis and animal model development. SARS-CoV-2 cannot infect mice due to incompatibility between its receptor binding domain and the murine ACE2 receptor. Through molecular modeling and empirical
Identifiants
pubmed: 33727353
pii: mBio.03149-20
doi: 10.1128/mBio.03149-20
pmc: PMC8092278
pii:
doi:
Substances chimiques
Recombinant Proteins
0
Spike Glycoprotein, Coronavirus
0
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI089728
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA260543
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI110700
Pays : United States
Informations de copyright
Copyright © 2021 Adams et al.
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