Serum 1,3-beta-D-glucan as a noninvasive test to predict histologic activity in patients with inflammatory bowel disease.
Beta-glucan
Crohn’s disease
Histologic activity
Inflammatory bowel disease
Noninvasive test
Ulcerative colitis
Journal
World journal of gastroenterology
ISSN: 2219-2840
Titre abrégé: World J Gastroenterol
Pays: United States
ID NLM: 100883448
Informations de publication
Date de publication:
07 Mar 2021
07 Mar 2021
Historique:
received:
11
11
2020
revised:
11
01
2021
accepted:
18
02
2021
entrez:
17
3
2021
pubmed:
18
3
2021
medline:
15
5
2021
Statut:
ppublish
Résumé
1,3-beta-D-glucan (BG) is a ubiquitous cell wall component of gut micro-organisms. We hypothesized that the serum levels of BG could reflect active intestinal inflammation in patients with inflammatory bowel disease. To determine whether the serum BG concentrations correlate with intestinal inflammation. A prospective observational study was performed in a tertiary referral center, from 2016 to 2019, in which serum BG was determined in 115 patients with Crohn's disease (CD), 51 with ulcerative colitis (UC), and 82 controls using a photometric detection kit. Inflammatory activity was determined by ileocolonoscopy, histopathology, magnetic resonance enterography, and biomarkers, including fecal calprotectin (FC), C-reactive protein, and a panel of cytokines. The ability of BG to detect active The serum BG levels were higher in CD patients than in controls ( Serum BG may represent an important novel noninvasive approach for detecting mucosal inflammation and therapeutically monitoring inflammatory bowel diseases, particularly in CD.
Sections du résumé
BACKGROUND
BACKGROUND
1,3-beta-D-glucan (BG) is a ubiquitous cell wall component of gut micro-organisms. We hypothesized that the serum levels of BG could reflect active intestinal inflammation in patients with inflammatory bowel disease.
AIM
OBJECTIVE
To determine whether the serum BG concentrations correlate with intestinal inflammation.
METHODS
METHODS
A prospective observational study was performed in a tertiary referral center, from 2016 to 2019, in which serum BG was determined in 115 patients with Crohn's disease (CD), 51 with ulcerative colitis (UC), and 82 controls using a photometric detection kit. Inflammatory activity was determined by ileocolonoscopy, histopathology, magnetic resonance enterography, and biomarkers, including fecal calprotectin (FC), C-reactive protein, and a panel of cytokines. The ability of BG to detect active
RESULTS
RESULTS
The serum BG levels were higher in CD patients than in controls (
CONCLUSION
CONCLUSIONS
Serum BG may represent an important novel noninvasive approach for detecting mucosal inflammation and therapeutically monitoring inflammatory bowel diseases, particularly in CD.
Identifiants
pubmed: 33727775
doi: 10.3748/wjg.v27.i9.866
pmc: PMC7941859
doi:
Substances chimiques
Biomarkers
0
Leukocyte L1 Antigen Complex
0
beta-Glucans
0
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
866-885Informations de copyright
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict-of-interest statement: The authors declare that they have no competing interests to report related to the work submitted for consideration of publication.
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