Leptin is Associated with the Tri-Ponderal Mass Index in Children: A Cross-Sectional Study.
Tri-ponderal mass index
adiposity
children
leptin
Journal
Adolescent health, medicine and therapeutics
ISSN: 1179-318X
Titre abrégé: Adolesc Health Med Ther
Pays: New Zealand
ID NLM: 101576821
Informations de publication
Date de publication:
2021
2021
Historique:
received:
10
11
2020
accepted:
05
02
2021
entrez:
17
3
2021
pubmed:
18
3
2021
medline:
18
3
2021
Statut:
epublish
Résumé
Obesity is characterized by the disproportionate expansion of the fat mass and is most commonly diagnosed using the Body Mass Index (BMI) z-score or percentile in children. However, these measures associate poorly with the fat mass. This is important, as adiposity is a more robust predictor of cardiometabolic risk than BMI-based measures, but there are limited clinical measures of adiposity in children. A new measure, the Tri-ponderal Mass Index (TMI, kg/m One hundred and eight children and adolescents were included in this cross-sectional study. Height and weight were used to calculate TMI. Plasma leptin was measured using ELISA. Multivariable regression analysis was applied to determine the predictors of TMI. The age range of participants included in this study was 8.00-16.90 years (female n=48, 44%). Leptin correlated with BMI percentile (r=0.64, p-value <0.0001) and TMI (r=0.71, p-value <0.0001). The multivariable regression analysis revealed that BMI percentile (Estimated Beta-coefficient 0.002, 95% CI 0.002-0.003, p-value <0.0001) and Leptin (Estimated Beta-coefficient 0.05, 95% CI 0.02-0.07, p-value 0.013) were associated with TMI. Leptin is associated with TMI in healthy children. The TMI is a feasible clinical measure of adiposity that may be used to stratify children and adolescents for further assessments and interventions to manage and attempt to prevent cardiometabolic comorbidities.
Sections du résumé
BACKGROUND
BACKGROUND
Obesity is characterized by the disproportionate expansion of the fat mass and is most commonly diagnosed using the Body Mass Index (BMI) z-score or percentile in children. However, these measures associate poorly with the fat mass. This is important, as adiposity is a more robust predictor of cardiometabolic risk than BMI-based measures, but there are limited clinical measures of adiposity in children. A new measure, the Tri-ponderal Mass Index (TMI, kg/m
METHODS
METHODS
One hundred and eight children and adolescents were included in this cross-sectional study. Height and weight were used to calculate TMI. Plasma leptin was measured using ELISA. Multivariable regression analysis was applied to determine the predictors of TMI.
RESULTS
RESULTS
The age range of participants included in this study was 8.00-16.90 years (female n=48, 44%). Leptin correlated with BMI percentile (r=0.64, p-value <0.0001) and TMI (r=0.71, p-value <0.0001). The multivariable regression analysis revealed that BMI percentile (Estimated Beta-coefficient 0.002, 95% CI 0.002-0.003, p-value <0.0001) and Leptin (Estimated Beta-coefficient 0.05, 95% CI 0.02-0.07, p-value 0.013) were associated with TMI.
CONCLUSION
CONCLUSIONS
Leptin is associated with TMI in healthy children. The TMI is a feasible clinical measure of adiposity that may be used to stratify children and adolescents for further assessments and interventions to manage and attempt to prevent cardiometabolic comorbidities.
Identifiants
pubmed: 33727877
doi: 10.2147/AHMT.S289973
pii: 289973
pmc: PMC7955735
doi:
Types de publication
Journal Article
Langues
eng
Pagination
9-15Informations de copyright
© 2021 Empringham et al.
Déclaration de conflit d'intérêts
M.C.S. was funded by the Pediatric Oncology Group of Ontario Research Unit and Hamilton Health Sciences and Foundation. B.E. received funding from Regional Medical Associates (RMA) Hamilton. The funding agencies had no participation in the conception of the research question, study design, data collection and analysis or conclusions. The authors report no other conflicts of interest in this work.
Références
Cancer Causes Control. 2018 Jan;29(1):167-183
pubmed: 29222610
Pediatrics. 1997 Jun;99(6):804-7
pubmed: 9164773
Pediatrics. 1998 Mar;101(3 Pt 2):505-18
pubmed: 12224657
N Engl J Med. 2017 Jul 6;377(1):13-27
pubmed: 28604169
N Engl J Med. 1997 Sep 25;337(13):869-73
pubmed: 9302300
JAMA. 2003 Nov 5;290(17):2271-6
pubmed: 14600185
Prog Cardiovasc Dis. 2014 Jan-Feb;56(4):369-81
pubmed: 24438728
Nutrition. 2020 Jun;74:110744
pubmed: 32217458
N Engl J Med. 2005 Oct 27;353(17):1802-9
pubmed: 16251536
N Engl J Med. 2007 Dec 6;357(23):2371-9
pubmed: 18057339
Nutrition. 2019 Apr;60:41-47
pubmed: 30529185
BMC Public Health. 2018 Apr 7;18(1):461
pubmed: 29625608
Am J Psychiatry. 1986 Aug;143(8):1024-7
pubmed: 3728717
Glob Health Promot. 2018 Sep;25(3):33-42
pubmed: 28134006
BMJ Open. 2013 Jun 20;3(6):
pubmed: 23794554
JAMA Pediatr. 2017 Jul 1;171(7):629-636
pubmed: 28505241
Obes Res. 2005 Aug;13(8):1476-84
pubmed: 16129731
Nutrients. 2018 Mar 27;10(4):
pubmed: 29584641
Atherosclerosis. 2015 Mar;239(1):67-72
pubmed: 25574859
Sci Rep. 2018 Nov 5;8(1):16336
pubmed: 30397217
Sleep Med. 2000 Feb 1;1(1):21-32
pubmed: 10733617
Cardiovasc Diabetol. 2011 Apr 28;10:36
pubmed: 21526991
J Clin Endocrinol Metab. 1997 Sep;82(9):2904-10
pubmed: 9284717
Br J Nutr. 2009 Apr;101(8):1262-6
pubmed: 18755049
Am J Public Health. 2004 Mar;94(3):473-83
pubmed: 14998817
Obes Rev. 2016 Feb;17(2):95-107
pubmed: 26696565
Obes Facts. 2017;10(3):207-215
pubmed: 28564650
An Pediatr (Barc). 2018 Sep;89(3):137-143
pubmed: 29478880
Int J Obes Relat Metab Disord. 1998 Dec;22(12):1197-208
pubmed: 9877255
Prev Sci. 2007 Sep;8(3):206-13
pubmed: 17549635
Sci Rep. 2020 Mar 13;10(1):4711
pubmed: 32170116
J Pediatr Endocrinol Metab. 2020 Feb 25;33(2):223-231
pubmed: 31809264
J Adolesc. 2002 Oct;25(5):535-50
pubmed: 12234559
Nat Med. 1995 Dec;1(12):1311-4
pubmed: 7489415
J Clin Endocrinol Metab. 2004 Aug;89(8):3872-8
pubmed: 15292320
N Engl J Med. 2007 Dec 6;357(23):2329-37
pubmed: 18057335
Prev Med. 1997 Nov-Dec;26(6):808-16
pubmed: 9388792
BMJ Open. 2014 Jun 26;4(6):e005295
pubmed: 24969784
JAMA. 2003 Nov 5;290(17):2277-83
pubmed: 14600186
Curr Opin Clin Nutr Metab Care. 2005 Nov;8(6):618-23
pubmed: 16205462
J R Soc Promot Health. 2006 Nov;126(6):262-7
pubmed: 17152319
Obes Rev. 2016 Jan;17(1):56-67
pubmed: 26440472
J Pediatr. 2008 Feb;152(2):201-6
pubmed: 18206689