Amino- and polyaminophthalazin-1(2
Pd cross-coupling
amination
complexes
cytotoxicity
phthalazinone
Journal
Beilstein journal of organic chemistry
ISSN: 1860-5397
Titre abrégé: Beilstein J Org Chem
Pays: Germany
ID NLM: 101250746
Informations de publication
Date de publication:
2021
2021
Historique:
received:
13
10
2020
accepted:
05
02
2021
entrez:
17
3
2021
pubmed:
18
3
2021
medline:
18
3
2021
Statut:
epublish
Résumé
Amino- and polyaminophthalazinones were synthesized by the palladium-catalyzed amination (alkyl- and arylamines, polyamines) of 4-bromophthalazinones in good yields. The coordinating properties of selected aminophthalazinones towards Cu(II) ions were investigated and the participation of the nitrogen atoms in the complexation of the metal ion was shown. A biological screening of the potential cytotoxicity of selected synthesized compounds on HT-29 and PC-3 cell lines, as well as on the L-929 cell line, proved that some amino derivatives of phthalazinone show interesting anticancer activities. The detailed synthesis, spectroscopic data, and biological assays are reported.
Identifiants
pubmed: 33727979
doi: 10.3762/bjoc.17.50
pmc: PMC7934800
doi:
Types de publication
Journal Article
Langues
eng
Pagination
558-568Informations de copyright
Copyright © 2021, Malinowski et al.
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