Early Gastrointestinal Progression to Immunotherapy in Lung Cancer: A Report of Two Cases.
Journal
Case reports in oncological medicine
ISSN: 2090-6706
Titre abrégé: Case Rep Oncol Med
Pays: United States
ID NLM: 101581035
Informations de publication
Date de publication:
2021
2021
Historique:
received:
23
12
2020
revised:
13
02
2021
accepted:
20
02
2021
entrez:
17
3
2021
pubmed:
18
3
2021
medline:
18
3
2021
Statut:
epublish
Résumé
Intestinal and pancreatic metastases are rare and often challenging to recognize and manage. Lung cancer patients with enteric involvement usually display poor outcomes. Hyperprogression to immunotherapy represents a concern, even though there is currently no agreement on its exact definition. Gastrointestinal hyperprogression to immune checkpoint inhibitors has not been described so far. In these cases, distinguishing disease-related symptoms from immune-related adverse events may represent a diagnostic conundrum. Here, we report two cases of non-small-cell lung cancer experiencing a rapid pancreatic and colic progression to immunotherapy, respectively. While further investigations to identify biomarkers associated with hyperprogression are warranted, clinicians should be aware of the potential unusual clinical presentations of this phenomenon.
Identifiants
pubmed: 33728080
doi: 10.1155/2021/6692538
pmc: PMC7939738
doi:
Types de publication
Case Reports
Langues
eng
Pagination
6692538Informations de copyright
Copyright © 2021 Federica Martorana et al.
Déclaration de conflit d'intérêts
The authors declare that there is no conflict of interest regarding the publication of this paper.
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