Compensating for verbal-motor deficits in neuropsychological assessment in movement disorders: sensitivity and specificity of the ECAS in Parkinson's and Huntington's diseases.
Cognitive assessment
ECAS
Huntington’s disease
Movement disorders
Parkinson’s disease
Psychological symptoms
Journal
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
ISSN: 1590-3478
Titre abrégé: Neurol Sci
Pays: Italy
ID NLM: 100959175
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
29
09
2020
accepted:
06
03
2021
pubmed:
18
3
2021
medline:
15
12
2021
entrez:
17
3
2021
Statut:
ppublish
Résumé
The study aims at investigating psychometric properties of the Edinburgh cognitive and behavioural ALS screen (ECAS) in Parkinson's (PD) and Huntington's (HD) diseases. The sensitivity and specificity of the ECAS in highlighting HD and PD cognitive-behavioural features and in differentiating between these two populations and from healthy controls (HC) were evaluated. Moreover, correlations between the ECAS and traditional cognitive measures, together with core clinical features, were analysed. Seventy-three PD patients, 38 HD patients, and 49 education-matched healthy participants were enrolled. Participants were administered the ECAS, together with other cognitive screening tools and psychological questionnaires. Patients' behavioural assessment was also carried out with carers. The ECAS distinguished between HD patients and HC and between the two clinical syndromes with high sensitivity and specificity. Even if the diagnostic accuracy of the ECAS in distinguishing between PD and HC was low, the PD cognitive phenotype was very well described by the ECAS performances. Convergent validity of the ECAS against other traditional cognitive screening was observed, as well as correlations with psychological aspects and typical clinical features, especially for the HD group. The ECAS represents a rapid and feasible tool, useful also in other neurodegenerative disorders affecting verbal-motor abilities than the amyotrophic lateral sclerosis such as PD and HD. Clinical applications in these neurodegenerative conditions require further investigations and, probably, some adaptations of the original test.
Identifiants
pubmed: 33728549
doi: 10.1007/s10072-021-05169-3
pii: 10.1007/s10072-021-05169-3
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4997-5006Informations de copyright
© 2021. Fondazione Società Italiana di Neurologia.
Références
Galtier I, Nieto A, Lorenzo JN, Barroso J (2016) Mild cognitive impairment in Parkinson’s disease: diagnosis and progression to dementia. J Clin Exp Neuropsychol 38:40–50. https://doi.org/10.1080/13803395.2015.1087465
doi: 10.1080/13803395.2015.1087465
pubmed: 26602176
Lawson RA, Yarnall AJ, Duncan GW et al (2014) Severity of mild cognitive impairment in early Parkinson’s disease contributes to poorer quality of life. Parkinsonism Relat Disord 20:1071–1075. https://doi.org/10.1016/j.parkreldis.2014.07.004
doi: 10.1016/j.parkreldis.2014.07.004
pubmed: 25074728
pmcid: 4194347
Hart EP, Dumas EM, Giltay EJ et al (2013) Cognition in Huntington’s disease in manifest, premanifest and converting gene carriers over ten years. J Huntingtons Dis 2:137–147. https://doi.org/10.3233/JHD-130059
doi: 10.3233/JHD-130059
pubmed: 25063511
Jacobs M, Hart EP, Roos RAC (2018) Cognitive performance and apathy predict unemployment in Huntington’s disease mutation carriers. J Neuropsychiatr Clin Neurosci 30:188–193. https://doi.org/10.1176/appi.neuropsych.17070144
doi: 10.1176/appi.neuropsych.17070144
Litvan I, Goldman JG, Tröster AI et al (2012) Diagnostic criteria for mild cognitive impairment in Parkinson’s disease: movement disorder society task force guidelines. Mov Disord 27:349–356. https://doi.org/10.1002/mds.24893
doi: 10.1002/mds.24893
pubmed: 22275317
pmcid: 3641655
Abrahams S, Newton J, Niven E et al (2014) Screening for cognition and behaviour changes in ALS. Amyotroph Lateral Scler Front Degener 15:9–14. https://doi.org/10.3109/21678421.2013.805784
doi: 10.3109/21678421.2013.805784
Poletti B, Solca F, Carelli L et al (2016) The validation of the Italian Edinburgh cognitive and behavioural ALS screen (ECAS). Amyotroph Lateral Scler Front Degener 17:489–498. https://doi.org/10.1080/21678421.2016.1183679
doi: 10.1080/21678421.2016.1183679
Tremolizzo L, Lizio A, Santangelo G et al (2020) ALS cognitive behavioral screen (ALS-CBS): normative values for the Italian population and clinical usability. Neurol Sci 41:835–841. https://doi.org/10.1007/s10072-019-04154-1
doi: 10.1007/s10072-019-04154-1
pubmed: 31807998
Rascovsky K, Hodges JR, Knopman D et al (2011) Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain 134:2456–2477. https://doi.org/10.1093/brain/awr179
doi: 10.1093/brain/awr179
pubmed: 21810890
pmcid: 3170532
Kourtesis P, Christidi F, Margioti E et al (2019) The Edinburgh cognitive and behavioral amyotrophic lateral sclerosis screen (ECAS): sensitivity in differentiating between ALS and Alzheimer’s disease in a Greek population. Amyotroph Lateral Scler Front Degener. https://doi.org/10.1080/21678421.2019.1655059
Foley JA, Niven EH, Paget A et al (2018) Sensitivity and specificity of the ECAS in Parkinson’s disease and progressive supranuclear palsy. https://doi.org/10.1155/2018/2426012
Kieburtz K, Penney JB, Corno P et al (1996) Unified Huntington’s disease rating scale: reliability and consistency. Mov Disord 11:136–142. https://doi.org/10.1002/mds.870110204
doi: 10.1002/mds.870110204
Fahn S (1987) Members of the UPDRS development committee. Unified Parkinson’s disease rating scale. Recent Dev Park Dis 2:293–304
Alberici A, Geroldi C, Cotelli M et al (2007) The frontal behavioural inventory (Italian version) differentiates frontotemporal lobar degeneration variants from Alzheimer’s disease. Neurol Sci 28:80–86. https://doi.org/10.1007/s10072-007-0791-3
doi: 10.1007/s10072-007-0791-3
pubmed: 17464470
Conti S, Bonazzi S, Laiacona M et al (2015) Montreal cognitive assessment (MoCA)-Italian version: regression based norms and equivalent scores. Neurol Sci 36:209–214
doi: 10.1007/s10072-014-1921-3
Serafin M, Surian L (2004) Il Test degli Occhi: uno strumento per valutare la “teoria della mente.”. G Ital Psicol 31:839–862. https://doi.org/10.1421/18849
doi: 10.1421/18849
Santangelo G, Raimo S, Siciliano M et al (2017) Assessment of apathy independent of physical disability: validation of the dimensional apathy scale in Italian healthy sample. Neurol Sci 38:303–309. https://doi.org/10.1007/s10072-016-2766-8
doi: 10.1007/s10072-016-2766-8
pubmed: 27844173
Pedrabissi L, Santinello M (1989) Inventario per l’ansia di «Stato» e di «Tratto»: nuova versione italiana dello STAI Forma Y: Manuale
Spielberger CD (2010) State-trait anxiety inventory. In: The Corsini Encyclopedia of Psychology. Wiley, Hoboken, pp 3–4
Centomo C, Sanavio E (1992) Padua inventory e Beck depression inventory: Indagine su studenti di scuola media superiore. Manuscr not Publ
Swets JA (1988) Measuring the accuracy of diagnostic systems. Science (80- ) 240:1285–1293
doi: 10.1126/science.3287615
Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Ser B 57:289–300. https://doi.org/10.1111/j.2517-6161.1995.tb02031.x
doi: 10.1111/j.2517-6161.1995.tb02031.x
Cohen J (2013) Statistical power analysis for the behavioral sciences. Routledge
Papoutsi M, Labuschagne I, Tabrizi SJ, Stout JC (2014) The cognitive burden in Huntington’s disease: pathology, phenotype, and mechanisms of compensation. Mov Disord 29:673–683. https://doi.org/10.1002/mds.25864
doi: 10.1002/mds.25864
pubmed: 24757115
Poletti B, Solca F, Carelli L et al (2018) Cognitive-behavioral longitudinal assessment in ALS: the Italian Edinburgh cognitive and behavioral ALS screen (ECAS). Amyotroph Lateral Scler Front Degener 19:387–395. https://doi.org/10.1080/21678421.2018.1473443
doi: 10.1080/21678421.2018.1473443
Enrici I, Adenzato M, Ardito RB et al (2015) Emotion processing in Parkinson’s disease: a three-level study on recognition, representation, and regulation. https://doi.org/10.1371/journal.pone.0131470
Tsuruya N, Kobayakawa M, Kawamura M (2011) Is “reading mind in the eyes” impaired in Parkinson’s disease? Parkinsonism Relat Disord. https://doi.org/10.1016/j.parkreldis.2010.09.001
Carelli L, Solca F, Faini A et al (2018) The complex interplay between depression/anxiety and executive functioning: insights from the ECAS in a large ALS population. Front Psychol 9:1–8. https://doi.org/10.3389/fpsyg.2018.00450
doi: 10.3389/fpsyg.2018.00450
Siciliano M, Trojano L, Trojsi F et al (2017) Edinburgh cognitive and behavioural ALS screen (ECAS)-Italian version: regression based norms and equivalent scores. Neurol Sci 38:1059–1068. https://doi.org/10.1007/s10072-017-2919-4
doi: 10.1007/s10072-017-2919-4
pubmed: 28332040
Gelb DJ, Oliver E, Gilman S (1999) Diagnostic criteria for Parkinson disease. Arch Neurol 56:33–39. https://doi.org/10.1001/archneur.56.1.33
doi: 10.1001/archneur.56.1.33
pubmed: 9923759