Systemic corticosteroids in coronavirus disease 2019 (COVID-19)-related smell dysfunction: an international view.

Adrenal Cortex Hormones / pharmacology COVID-19 / complications Drug-Related Side Effects and Adverse Reactions / diagnosis Global Health Humans Medication Therapy Management / standards Needs Assessment Olfaction Disorders / drug therapy Olfactory Mucosa / drug effects Remission, Spontaneous Research Design SARS-CoV-2 / pathogenicity
COVID-19 SARS-CoV-2 corticosteroids olfaction disorder smell

Journal

International forum of allergy & rhinology
ISSN: 2042-6984
Titre abrégé: Int Forum Allergy Rhinol
Pays: United States
ID NLM: 101550261

Informations de publication

Date de publication:
07 2021
Historique:
revised: 02 02 2021
received: 04 12 2020
accepted: 03 02 2021
pubmed: 18 3 2021
medline: 7 7 2021
entrez: 17 3 2021
Statut: ppublish

Résumé

The frequent association between coronavirus disease 2019 (COVID-19) and olfactory dysfunction is creating an unprecedented demand for a treatment of the olfactory loss. Systemic corticosteroids have been considered as a therapeutic option. However, based on current literature, we call for caution using these treatments in early COVID-19-related olfactory dysfunction because: (1) evidence supporting their usefulness is weak; (2) the rate of spontaneous recovery of COVID-19-related olfactory dysfunction is high; and (3) corticosteroids have well-known potential adverse effects. We encourage randomized placebo-controlled trials investigating the efficacy of systemic steroids in this indication and strongly emphasize to initially consider smell training, which is supported by a robust evidence base and has no known side effects.

Identifiants

DOI: 10.1002/alr.22788 PMID: 33728824 PMC: PMC8251281
pubmed: 33728824
doi: 10.1002/alr.22788
pmc: PMC8251281
doi:

Substances chimiques

Adrenal Cortex Hormones 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1041-1046

Informations de copyright

© 2021 ARS-AAOA, LLC.

Références

N Engl J Med. 2021 Feb 25;384(8):693-704
pubmed: 32678530
Rhinology. 2020 Feb 20;58(Suppl S29):1-464
pubmed: 32077450
Laryngoscope. 2012 Apr;122(4):747-50
pubmed: 22302665
Ann Otol Rhinol Laryngol. 2021 May;130(5):513-519
pubmed: 33025798
Eur Arch Otorhinolaryngol. 2016 Apr;273(4):939-43
pubmed: 26141752
Curr Allergy Asthma Rep. 2020 Oct 13;20(12):76
pubmed: 33048282
Laryngoscope. 2018 Jan;128(1):10-15
pubmed: 28556265
Chem Senses. 2020 Dec 5;45(9):875-881
pubmed: 33033827
Neural Regen Res. 2018 Oct;13(10):1711-1714
pubmed: 30136681
Clin Otolaryngol. 2021 Jan;46(1):16-22
pubmed: 32854169
Eur J Neurol. 2020 Nov;27(11):2318-2321
pubmed: 32677329
Physiol Rep. 2020 Sep;8(18):e14578
pubmed: 32975884
Eur Arch Otorhinolaryngol. 2021 Jan 9;:
pubmed: 33423106
Int Forum Allergy Rhinol. 2021 Jul;11(7):1041-1046
pubmed: 33728824
Acta Otolaryngol. 2020 Dec;140(12):1032-1035
pubmed: 32852240
Int Forum Allergy Rhinol. 2020 Aug;10(8):944-950
pubmed: 32301284
Int Forum Allergy Rhinol. 2018 Sep;8(9):977-981
pubmed: 29901865
Dan Med J. 2020 Aug 1;67(8):
pubmed: 32741438
Laryngoscope. 2004 Oct;114(10):1764-9
pubmed: 15454769
Int Forum Allergy Rhinol. 2019 Feb;9(2):165-176
pubmed: 30472771
Indian J Otolaryngol Head Neck Surg. 2020 Oct 14;:1-6
pubmed: 33078125
Otolaryngol Head Neck Surg. 2021 Mar;164(3):512-518
pubmed: 32867582
Epilepsia. 2020 Aug;61(8):e90-e94
pubmed: 32589794
Rhinology. 1994 Sep;32(3):113-8
pubmed: 7530857
Laryngoscope. 2020 Nov;130(11):2680-2685
pubmed: 32794209
Otolaryngol Head Neck Surg. 2020 Dec;163(6):1144-1149
pubmed: 32600175
Eur Arch Otorhinolaryngol. 2021 Jul;278(7):2363-2369
pubmed: 33385250
J Laryngol Otol. 2020 Aug;134(8):703-709
pubmed: 32782030
Philos Trans R Soc Lond B Biol Sci. 2020 Jun 8;375(1800):20190265
pubmed: 32306872
Neurology. 2019 Aug 27;93(9):e841-e850
pubmed: 31358617
J Intern Med. 2021 Jan 5;:
pubmed: 33403772
Am J Otolaryngol. 2020 Nov - Dec;41(6):102725
pubmed: 32979666
Am J Otolaryngol. 2020 Nov - Dec;41(6):102639
pubmed: 32682192
Case Rep Otolaryngol. 2020 Aug 8;2020:5892047
pubmed: 32802540
Cochrane Database Syst Rev. 2013 Jul 02;(7):CD003998
pubmed: 23818120
Int Forum Allergy Rhinol. 2020 Sep;10(9):1065-1086
pubmed: 32567798
Eur Arch Otorhinolaryngol. 2021 Jan;278(1):101-108
pubmed: 32754871
Int Forum Allergy Rhinol. 2020 Jul;10(7):821-831
pubmed: 32329222
Acta Otolaryngol. 2012 Jun;132 Suppl 1:S27-31
pubmed: 22582778
Rhinol Suppl. 2017 Mar;54(26):1-30
pubmed: 29528615
Int Forum Allergy Rhinol. 2021 May;11(5):837-845
pubmed: 32970395
Allergy. 2021 Mar;76(3):677-688
pubmed: 33075144

Auteurs

Caroline Huart (C)

Department of Otorhinolaryngology, Cliniques universitaires Saint-Luc, Brussels, Belgium.
Institute of Neuroscience, Univeristé catholique de Louvain, Brussels, Belgium.

Carl M Philpott (CM)

The Norfolk Smell and Taste Clinic, Norfolk and Waveney ENT Service, Gorleston, UK.
Norwich Medical School, University of East Anglia, Norwich, UK.

Aytug Altundag (A)

Department of Otorhinolaryngology, Biruni University, Istanbul, Turkey.

Alexander W Fjaeldstad (AW)

Flavour Clinic, Department of Otorhinolaryngology, Regional Hospital West Jutland, Holstebro, Denmark.
Flavour Institute, Aarhus University, Aarhus, Denmark.

Johannes Frasnelli (J)

Department of Anatomy, Université du Québec à Trois-Rivières, Trois-Rivières, Quebec, Canada.

Simon Gane (S)

Department of Rhinology, Royal National ENT Hospital, University College London Hospitals NHS Foundation Trust, London, UK.
UCL Ear Institute, University College London, London, UK.

Julien W Hsieh (JW)

Department of Otorhinolaryngology-Head and Neck Surgery, Rhinology-Olfactory Unit, Geneva University Hospitals, Geneva, Switzerland.

Eric H Holbrook (EH)

Massachusetts Eye and Ear, Harvard University, Boston, Massachusetts.

Iordanis Konstantinidis (I)

2nd Academic ORL Department, Papageorgiou Hospital, Aristotle University, Thessaloniki, Greece.

Basile N Landis (BN)

Department of Otorhinolaryngology-Head and Neck Surgery, Rhinology-Olfactory Unit, Geneva University Hospitals, Geneva, Switzerland.

Alberto Macchi (A)

ENT clinic Asst-Settelaghi-University of Insubriae, Varese, Italy.

Christian A Mueller (CA)

Department of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria.

Simona Negoias (S)

Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Basel, CH-4051, Basel, Switzerland.

Jayant M Pinto (JM)

Section of Otolaryngology-Head and Neck Surgery, The University of Chicago, Chicago, Illinois.

Sophia C Poletti (SC)

Department of Otorhinolaryngology, Inselspital University Hospital Bern, Bern, Switzerland.

Vijay R Ramakrishnan (VR)

Department of Otolaryngology-Head and Neck Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

Philippe Rombaux (P)

Department of Otorhinolaryngology, Cliniques universitaires Saint-Luc, Brussels, Belgium.
Institute of Neuroscience, Univeristé catholique de Louvain, Brussels, Belgium.

Jan Vodicka (J)

Department of Otorhinolaryngology and Head and Neck Surgery, Hospital of Pardubice, Pardubice, Czech Republic.

Antje Welge-Lüessen (A)

Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Basel, CH-4051, Basel, Switzerland.

Katherine L Whitcroft (KL)

UCL Ear Institute, University College London, London, UK.
The Centre for Olfactory Research and Applications, Institute of Philosophy, School of Advanced Study, London, UK.

Thomas Hummel (T)

Smell and Taste Clinic, Department of Otorhinolaryngology, TU Dresden, Dresden, Germany.

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questionsmedicales.fr › Hormones corticosurrénaliennes › Systemic corticosteroids in coronavirus...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Systemic corticosteroids in coronavirus...
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questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Prestations des soins de santé › Évaluation des besoins › Systemic corticosteroids in coronavirus...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Troubles sensitifs › Troubles de l'olfaction › Systemic corticosteroids in coronavirus...
questionsmedicales.fr › Tissus › Membranes › Muqueuse › Muqueuse respiratoire › Muqueuse nasale › Muqueuse olfactive › Systemic corticosteroids in coronavirus...
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