Geranylgeranyl diphosphate synthase deficiency hyperactivates macrophages and aggravates lipopolysaccharide-induced acute lung injury.

Acute Lung Injury / chemically induced Animals Cytokines / metabolism Disease Models, Animal Gene Expression Regulation / drug effects Inflammation / drug therapy Lipopolysaccharides / pharmacology Lung / drug effects Macrophage Activation / drug effects Macrophages / drug effects Mice
ARDS GGPPS NF-κB Rac1 macrophage

Journal

American journal of physiology. Lung cellular and molecular physiology
ISSN: 1522-1504
Titre abrégé: Am J Physiol Lung Cell Mol Physiol
Pays: United States
ID NLM: 100901229

Informations de publication

Date de publication:
01 06 2021
Historique:
pubmed: 18 3 2021
medline: 28 7 2021
entrez: 17 3 2021
Statut: ppublish

Résumé

Macrophage activation is a key contributing factor for excessive inflammatory responses of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). Geranylgeranyl diphosphate synthase (GGPPS) plays a key role in the development of inflammatory diseases. Our group previously showed that GGPPS in alveolar epithelium have deleterious effects on acute lung injury induced by LPS or mechanical ventilation. Herein, we examined the role of GGPPS in modulating macrophage activation in ALI/ARDS. We found significant increased GGPPS expression in alveolar macrophages in patients with ARDS compared with healthy volunteers and in ALI mice induced by LPS. GGPPS-floxed control (

Identifiants

DOI: 10.1152/ajplung.00281.2020 PMID: 33729030
pubmed: 33729030
doi: 10.1152/ajplung.00281.2020
doi:

Substances chimiques

Cytokines 0
Lipopolysaccharides 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

L1011-L1024

Auteurs

Jiajia Jin (J)

Department of Respiratory and Critical Care Medicine, Jinling Hospital, the First School of Clinical Medicine, Southern Medical University (Guangzhou), Nanjing, China.
Department of Respiratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.

Hong Qian (H)

Department of Orthopaedic Surgery, Jinling Hospital, the First School of Clinical Medicine, Southern Medical University, Nanjing, China.

Bing Wan (B)

Department of Respiratory and Critical Care Medicine, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China.

Li Zhou (L)

Department of Respiratory and Critical Care Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.

Cen Chen (C)

Department of Respiratory and Critical Care Medicine, Jinling Hospital, the First School of Clinical Medicine, Southern Medical University (Guangzhou), Nanjing, China.

Yanling Lv (Y)

The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, China.

Meizi Chen (M)

Department of General Internal Medicine, the First People's Hospital of Chenzhou, Chenzhou, China.

Suhua Zhu (S)

Department of Respiratory and Critical Care Medicine, Jinling Hospital, the First School of Clinical Medicine, Southern Medical University (Guangzhou), Nanjing, China.

Liang Ye (L)

Department of Respiratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.

Xiaoxia Wang (X)

Department of Intensive Care Unit, Inner Mongolia People's Hospital, Inner Mongolia Autonomous Region, Hohhot, China.

Wujian Xu (W)

Department of Respiratory and Critical Care Medicine, Jinling Hospital, the First School of Clinical Medicine, Southern Medical University (Guangzhou), Nanjing, China.

Tangfeng Lv (T)

Department of Respiratory and Critical Care Medicine, Jinling Hospital, the First School of Clinical Medicine, Southern Medical University (Guangzhou), Nanjing, China.

Yong Song (Y)

Department of Respiratory and Critical Care Medicine, Jinling Hospital, the First School of Clinical Medicine, Southern Medical University (Guangzhou), Nanjing, China.

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Classifications MeSH

questionsmedicales.fr › Maladies de l'appareil respiratoire › Maladies pulmonaires › Lésion pulmonaire aigüe › Geranylgeranyl diphosphate synthase deficiency...
questionsmedicales.fr › Eucaryotes › Animaux › Geranylgeranyl diphosphate synthase deficiency...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Geranylgeranyl diphosphate synthase deficiency...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Geranylgeranyl diphosphate synthase deficiency...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Geranylgeranyl diphosphate synthase deficiency...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Geranylgeranyl diphosphate synthase deficiency...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Toxines bactériennes › Endotoxines › Lipopolysaccharides › Geranylgeranyl diphosphate synthase deficiency...
questionsmedicales.fr › Appareil respiratoire › Poumon › Geranylgeranyl diphosphate synthase deficiency...
questionsmedicales.fr › Phénomènes du système immunitaire › Cytotoxicité immunologique › Activation des macrophages › Geranylgeranyl diphosphate synthase deficiency...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Geranylgeranyl diphosphate synthase deficiency...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Geranylgeranyl diphosphate synthase deficiency...