Gut-derived acetate promotes B10 cells with antiinflammatory effects.

Acetates / blood Acetyl Coenzyme A / metabolism Acetylation Animals Arthritis, Experimental / immunology B-Lymphocytes, Regulatory / drug effects Cell Differentiation / drug effects Dietary Fiber / pharmacology Fatty Acids, Volatile / metabolism Female Humans Interleukin-10 Male Mice, Inbred C57BL Mice, Mutant Strains Neutrophils / cytology Receptors, G-Protein-Coupled / genetics
Beta cells Immunology Metabolism

Journal

JCI insight
ISSN: 2379-3708
Titre abrégé: JCI Insight
Pays: United States
ID NLM: 101676073

Informations de publication

Date de publication:
08 04 2021
Historique:
received: 18 09 2020
accepted: 03 03 2021
pubmed: 18 3 2021
medline: 21 1 2022
entrez: 17 3 2021
Statut: epublish

Résumé

Autoimmune diseases are characterized by a breakdown of immune tolerance partly due to environmental factors. The short-chain fatty acid acetate, derived mostly from gut microbial fermentation of dietary fiber, promotes antiinflammatory Tregs and protects mice from type 1 diabetes, colitis, and allergies. Here, we show that the effects of acetate extend to another important immune subset involved in tolerance, the IL-10-producing regulatory B cells (B10 cells). Acetate directly promoted B10 cell differentiation from mouse B1a cells both in vivo and in vitro. These effects were linked to metabolic changes through the increased production of acetyl-coenzyme A, which fueled the TCA cycle and promoted posttranslational lysine acetylation. Acetate also promoted B10 cells from human blood cells through similar mechanisms. Finally, we identified that dietary fiber supplementation in healthy individuals was associated with increased blood-derived B10 cells. Direct delivery of acetate or indirect delivery via diets or bacteria that produce acetate might be a promising approach to restore B10 cells in noncommunicable diseases.

Identifiants

DOI: 10.1172/jci.insight.144156 PMID: 33729999 PMC: PMC8119207
pubmed: 33729999
pii: 144156
doi: 10.1172/jci.insight.144156
pmc: PMC8119207
doi:
pii:

Substances chimiques

Acetates 0
Dietary Fiber 0
Fatty Acids, Volatile 0
Ffar2 protein, mouse 0
IL10 protein, mouse 0
Receptors, G-Protein-Coupled 0
Interleukin-10 130068-27-8
Acetyl Coenzyme A 72-89-9

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Références

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Auteurs

C I Daïen (CI)

Charles Perkins Centre, The University of Sydney, New South Wales, Sydney, Australia.
Faculty of Medicine and Health, The University of Sydney School of Medicine, New South Wales, Sydney, Australia.
Department of Rheumatology, Montpellier Hospital, University of Montpellier, Montpellier, France.
Institute of Molecular Genetics of Montpellier, UMR5535, University of Montpellier, Montpellier, France.

J Tan (J)

Charles Perkins Centre, The University of Sydney, New South Wales, Sydney, Australia.
Faculty of Medicine and Health, The University of Sydney School of Medicine, New South Wales, Sydney, Australia.
Human Health, Nuclear Science & Technology and Landmark Infrastructure (NSTLI) Australian Nuclear Science and Technology Organisation, New South Wales, Sydney, Australia.

R Audo (R)

Charles Perkins Centre, The University of Sydney, New South Wales, Sydney, Australia.
Faculty of Medicine and Health, The University of Sydney School of Medicine, New South Wales, Sydney, Australia.
Department of Rheumatology, Montpellier Hospital, University of Montpellier, Montpellier, France.
Institute of Molecular Genetics of Montpellier, UMR5535, University of Montpellier, Montpellier, France.

J Mielle (J)

Charles Perkins Centre, The University of Sydney, New South Wales, Sydney, Australia.
Faculty of Medicine and Health, The University of Sydney School of Medicine, New South Wales, Sydney, Australia.
Institute of Molecular Genetics of Montpellier, UMR5535, University of Montpellier, Montpellier, France.

L E Quek (LE)

Charles Perkins Centre, The University of Sydney, New South Wales, Sydney, Australia.
School of Mathematics and Statistics and.

J R Krycer (JR)

Charles Perkins Centre, The University of Sydney, New South Wales, Sydney, Australia.
School of Life and Environmental Sciences, The University of Sydney, New South Wales, Sydney, Australia.

A Angelatos (A)

Charles Perkins Centre, The University of Sydney, New South Wales, Sydney, Australia.
Faculty of Medicine and Health, The University of Sydney School of Medicine, New South Wales, Sydney, Australia.

M Duraes (M)

Department of Gynecology, Montpellier Hospital, University of Montpellier, Montpellier, France.

G Pinget (G)

Charles Perkins Centre, The University of Sydney, New South Wales, Sydney, Australia.
Faculty of Medicine and Health, The University of Sydney School of Medicine, New South Wales, Sydney, Australia.

D Ni (D)

Charles Perkins Centre, The University of Sydney, New South Wales, Sydney, Australia.
Faculty of Medicine and Health, The University of Sydney School of Medicine, New South Wales, Sydney, Australia.

R Robert (R)

Department of Physiology and.

M J Alam (MJ)

Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.

M C B Amian (MCB)

Charles Perkins Centre, The University of Sydney, New South Wales, Sydney, Australia.
Faculty of Medicine and Health, The University of Sydney School of Medicine, New South Wales, Sydney, Australia.
School of Life and Environmental Sciences, The University of Sydney, New South Wales, Sydney, Australia.

F Sierro (F)

Faculty of Medicine and Health, The University of Sydney School of Medicine, New South Wales, Sydney, Australia.
Human Health, Nuclear Science & Technology and Landmark Infrastructure (NSTLI) Australian Nuclear Science and Technology Organisation, New South Wales, Sydney, Australia.

A Parmar (A)

Human Health, Nuclear Science & Technology and Landmark Infrastructure (NSTLI) Australian Nuclear Science and Technology Organisation, New South Wales, Sydney, Australia.
Brain and Mind Centre, The University of Sydney, New South Wales, Sydney, Australia.

G Perkins (G)

Biosciences platform, NSTLI Australian Nuclear Science and Technology Organisation, New South Wales, Sydney, Australia.

S Hoque (S)

Charles Perkins Centre, The University of Sydney, New South Wales, Sydney, Australia.
School of Mathematics and Statistics and.

A K Gosby (AK)

Charles Perkins Centre, The University of Sydney, New South Wales, Sydney, Australia.
School of Life and Environmental Sciences, The University of Sydney, New South Wales, Sydney, Australia.

S J Simpson (SJ)

Charles Perkins Centre, The University of Sydney, New South Wales, Sydney, Australia.
School of Life and Environmental Sciences, The University of Sydney, New South Wales, Sydney, Australia.

R V Ribeiro (RV)

Charles Perkins Centre, The University of Sydney, New South Wales, Sydney, Australia.
School of Life and Environmental Sciences, The University of Sydney, New South Wales, Sydney, Australia.

C R Mackay (CR)

Department of Physiology and.

L Macia (L)

Charles Perkins Centre, The University of Sydney, New South Wales, Sydney, Australia.
Faculty of Medicine and Health, The University of Sydney School of Medicine, New South Wales, Sydney, Australia.

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Classifications MeSH

questionsmedicales.fr › Lipides › Acides gras › Acides gras volatils › Acétates › Gut-derived acetate promotes B10 cells with...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › Coenzyme A › Acyl coenzyme A › Acétyl coenzyme A › Gut-derived acetate promotes B10 cells with...
questionsmedicales.fr › Métabolisme › Acylation › Acétylation › Gut-derived acetate promotes B10 cells with...
questionsmedicales.fr › Eucaryotes › Animaux › Gut-derived acetate promotes B10 cells with...
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › Arthrite expérimentale › Gut-derived acetate promotes B10 cells with...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › Sous-populations de lymphocytes B › Lymphocytes B régulateurs › Gut-derived acetate promotes B10 cells with...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Gut-derived acetate promotes B10 cells with...
questionsmedicales.fr › Aliments et boissons › Aliments › Fibre alimentaire › Gut-derived acetate promotes B10 cells with...
questionsmedicales.fr › Lipides › Acides gras › Acides gras volatils › Gut-derived acetate promotes B10 cells with...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Gut-derived acetate promotes B10 cells with...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-10 › Gut-derived acetate promotes B10 cells with...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Gut-derived acetate promotes B10 cells with...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souches mutantes de souris › Gut-derived acetate promotes B10 cells with...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Granulocytes neutrophiles › Gut-derived acetate promotes B10 cells with...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Gut-derived acetate promotes B10 cells with...