Identification and disruption of a neural mechanism for accumulating prospective metacognitive information prior to decision-making.
anterior lateral prefrontal cortex
decision-making
functional magnetic resonance imaging
prospective metacognition
transcranial magnetic stimulation
Journal
Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320
Informations de publication
Date de publication:
21 04 2021
21 04 2021
Historique:
received:
30
07
2020
revised:
13
01
2021
accepted:
19
02
2021
pubmed:
18
3
2021
medline:
11
5
2021
entrez:
17
3
2021
Statut:
ppublish
Résumé
More than one type of probability must be considered when making decisions. It is as necessary to know one's chance of performing choices correctly as it is to know the chances that desired outcomes will follow choices. We refer to these two choice contingencies as internal and external probability. Neural activity across many frontal and parietal areas reflected internal and external probabilities in a similar manner during decision-making. However, neural recording and manipulation approaches suggest that one area, the anterior lateral prefrontal cortex (alPFC), is highly specialized for making prospective, metacognitive judgments on the basis of internal probability; it is essential for knowing which decisions to tackle, given its assessment of how well they will be performed. Its activity predicted prospective metacognitive judgments, and individual variation in activity predicted individual variation in metacognitive judgments. Its disruption altered metacognitive judgments, leading participants to tackle perceptual decisions they were likely to fail.
Identifiants
pubmed: 33730554
pii: S0896-6273(21)00124-0
doi: 10.1016/j.neuron.2021.02.024
pmc: PMC8063717
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1396-1408.e7Subventions
Organisme : Medical Research Council
ID : G0400593
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P024955/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT100973AIA
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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