Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis.

Amino Acids / metabolism Animals Cell Nucleus / metabolism Diabetes Mellitus, Type 2 / metabolism Down-Regulation Glucose / metabolism Glucose Intolerance / complications Homeodomain Proteins / metabolism Homeostasis Hyperglycemia / metabolism Insulin / genetics Insulin Secretion Islets of Langerhans / metabolism Mechanistic Target of Rapamycin Complex 1 / metabolism Mice, Inbred C57BL Models, Biological Organ Specificity Protein Stability Protein Transport Signal Transduction Trans-Activators / metabolism Transcription, Genetic rab1 GTP-Binding Proteins / metabolism
PDX1 Rab1A alpha-cell amino acids beta-cell diabetes glucose homeostasis insulin mTOR trans-differentiation

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
16 03 2021
Historique:
received: 01 09 2020
revised: 28 12 2020
accepted: 16 02 2021
entrez: 17 3 2021
pubmed: 18 3 2021
medline: 27 1 2022
Statut: ppublish

Résumé

Rab1A is a small GTPase known for its role in vesicular trafficking. Recent evidence indicates that Rab1A is essential for amino acids (aas) sensing and signaling to regulate mTORC1 in normal and cancer cells. However, Rab1A's in vivo function in mammals is not known. Here, we report the generation of tamoxifen (TAM)-induced whole body Rab1A knockout (Rab1A

Identifiants

DOI: 10.1016/j.celrep.2021.108830 PMID: 33730578 PMC: PMC8062038
pubmed: 33730578
pii: S2211-1247(21)00144-3
doi: 10.1016/j.celrep.2021.108830
pmc: PMC8062038
mid: NIHMS1684385
pii:
doi:

Substances chimiques

Amino Acids 0
Homeodomain Proteins 0
Insulin 0
Trans-Activators 0
pancreatic and duodenal homeobox 1 protein 0
Mechanistic Target of Rapamycin Complex 1 EC 2.7.11.1
rab1 GTP-Binding Proteins EC 3.6.5.2
Glucose IY9XDZ35W2

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

108830

Subventions

Organisme : NCI NIH HHS
ID : R01 CA173519
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK124897
Pays : United States

Informations de copyright

Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

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Auteurs

Xin Zhang (X)

Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08901, USA; Department of Pharmacology, Robert Wood Johnson Medical School, Rutgers, the State University of New Jersey, 675 Hoes Lane, Piscataway, NJ 08854, USA.

Xiaowen Wang (X)

Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08901, USA; Department of Pharmacology, Robert Wood Johnson Medical School, Rutgers, the State University of New Jersey, 675 Hoes Lane, Piscataway, NJ 08854, USA.

Ziqiang Yuan (Z)

Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08901, USA; Department of Surgery, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08901, USA.

Sarah J Radford (SJ)

Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08901, USA.

Chen Liu (C)

Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08901, USA.

Steven K Libutti (SK)

Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08901, USA; Department of Surgery, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08901, USA.

X F Steven Zheng (XFS)

Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08901, USA; Department of Pharmacology, Robert Wood Johnson Medical School, Rutgers, the State University of New Jersey, 675 Hoes Lane, Piscataway, NJ 08854, USA. Electronic address: zhengst@cinj.rutgers.edu.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Amino acids-Rab1A-mTORC1 signaling controls...
questionsmedicales.fr › Eucaryotes › Animaux › Amino acids-Rab1A-mTORC1 signaling controls...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Noyau de la cellule › Amino acids-Rab1A-mTORC1 signaling controls...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › Amino acids-Rab1A-mTORC1 signaling controls...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Régulation négative › Amino acids-Rab1A-mTORC1 signaling controls...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Amino acids-Rab1A-mTORC1 signaling controls...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles du métabolisme du glucose › Hyperglycémie › Intolérance au glucose › Amino acids-Rab1A-mTORC1 signaling controls...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Protéines à homéodomaine › Amino acids-Rab1A-mTORC1 signaling controls...
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › Amino acids-Rab1A-mTORC1 signaling controls...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles du métabolisme du glucose › Hyperglycémie › Amino acids-Rab1A-mTORC1 signaling controls...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones pancréatiques › Insulines › Insuline › Amino acids-Rab1A-mTORC1 signaling controls...
questionsmedicales.fr › Phénomènes physiologiques › Sécrétion d'insuline › Amino acids-Rab1A-mTORC1 signaling controls...
questionsmedicales.fr › Système endocrine › Glandes endocrines › Ilots pancréatiques › Amino acids-Rab1A-mTORC1 signaling controls...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Sérine-thréonine kinases TOR › Complexe-1 cible mécanistique de la rapamycine › Amino acids-Rab1A-mTORC1 signaling controls...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Amino acids-Rab1A-mTORC1 signaling controls...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Amino acids-Rab1A-mTORC1 signaling controls...
questionsmedicales.fr › Phénomènes physiologiques › Spécificité d'organe › Amino acids-Rab1A-mTORC1 signaling controls...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Stabilité protéique › Amino acids-Rab1A-mTORC1 signaling controls...
questionsmedicales.fr › Métabolisme › Transport biologique › Transport des protéines › Amino acids-Rab1A-mTORC1 signaling controls...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Amino acids-Rab1A-mTORC1 signaling controls...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales régulatrices ou accessoires › Transactivateurs › Amino acids-Rab1A-mTORC1 signaling controls...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Transcription génétique › Amino acids-Rab1A-mTORC1 signaling controls...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines G › Protéines G monomériques › Protéines G rab › Protéines G rab1 › Amino acids-Rab1A-mTORC1 signaling controls...