Perinatally acquired HIV infection is associated with abnormal blood mitochondrial function during childhood/adolescence.
Journal
AIDS (London, England)
ISSN: 1473-5571
Titre abrégé: AIDS
Pays: England
ID NLM: 8710219
Informations de publication
Date de publication:
15 07 2021
15 07 2021
Historique:
pubmed:
18
3
2021
medline:
7
8
2021
entrez:
17
3
2021
Statut:
ppublish
Résumé
We assessed differences in mitochondrial function between youth living with perinatal HIV (YPHIV) and youth perinatally HIV-exposed but uninfected (YPHEU). Cross-sectional analysis. We measured lactate and pyruvate values, as well as mitochondrial Complex I and Complex IV activity in peripheral blood mononuclear cells. Logistic or linear regression models were fit, as appropriate, to assess the association between PHIV status and each mitochondrial parameter, adjusted for confounders. We introduced interaction terms to assess effect modification of PHIV status on the relationship between anthropometric factors and each mitochondrial parameter. Among YPHIV, similar regression models were fit to assess the relationship between HIV-associated factors and each mitochondrial outcome. A total of 243 YPHIV and 118 YPHEU were compared. On average, YPHIV had higher lactate/pyruvate ratio (β: 7.511, 95% confidence interval [95% CI]: 0.402, 14.620) and Complex IV activity (β: 0.037, 95% CI: 0.002, 0.072) compared to YPHEU, adjusted for confounders. Among YPHIV, body mass index Z score (BMIZ) and Complex I activity were inversely associated, whereas, among YPHEU, there was a positive association (β for interaction: -0.048, P = 0.003). Among YPHIV, current (β: -0.789, 95% CI: -1.174, -0.404) and nadir CD4+% (β: -0.605, 95% CI: -1.086, -0.125) were inversely associated with lactate/pyruvate ratio; higher current (4.491, 95% CI: 0.754, 8.229) and peak (7.978, 95% CI: 1.499, 14.457) HIV RNA levels were positively associated with lactate/pyruvate ratio in adjusted models. Mitochondrial function and substrate utilization appear perturbed in YPHIV compared to YPHEU. Increasing immunosuppression and viremia are associated with mitochondrial dysfunction among YPHIV.
Identifiants
pubmed: 33730749
doi: 10.1097/QAD.0000000000002884
pii: 00002030-202107150-00006
pmc: PMC8243810
mid: NIHMS1682713
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1385-1394Subventions
Organisme : NICHD NIH HHS
ID : U01 HD052104
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL115505
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM113134
Pays : United States
Organisme : NINR NIH HHS
ID : R01 NR012885
Pays : United States
Organisme : NICHD NIH HHS
ID : U01 HD052102
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM103341
Pays : United States
Informations de copyright
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
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