Genetic variants of tissue inhibitors of matrix metalloproteinase 1 (rs4898) and 2 (rs8179090) in diverticulosis.
Journal
European journal of gastroenterology & hepatology
ISSN: 1473-5687
Titre abrégé: Eur J Gastroenterol Hepatol
Pays: England
ID NLM: 9000874
Informations de publication
Date de publication:
01 12 2021
01 12 2021
Historique:
pubmed:
19
3
2021
medline:
12
4
2022
entrez:
18
3
2021
Statut:
ppublish
Résumé
Diverticulosis affects approximately 60% of population after 60th year of age. Diverticular disease is symptomatic diverticulosis characterized by abdominal pain, flatulence and bloating, and bowel habits change. Age and lifestyle are risk factors for diverticulosis, additionally genetic predisposition is postulated. The aim of the study was to assess whether tissue inhibitors of matrix metalloproteinase (TIMP) 1 rs4898 and TIMP2 rs8179090 genetic variants are related to colonic diverticulosis. The study included 220 patients, 100 with colon diverticulosis diagnosed on colonoscopy and 120 controls. TIMP1 rs4898 and TIMP2 rs8179090 variants were examined using PCR-restriction fragments length polymorphism from a blood sample. Allele T of TIMP1 rs4898 was more frequent in male patients with diverticulosis than in controls (P < 0.01), whereas in women there were no differences in its distribution, both in heterozygotes and homozygotes or in homozygotes separately, proving a recessive effect. TIMP2 s8179090 allele G frequency was 0.95 in cases and controls, there were no CC homozygotes identified, and no associations with diverticulosis showed. TIMP1 rs4898 allele T may be a genetic determinant of the risk of diverticulosis in men.
Identifiants
pubmed: 33731593
doi: 10.1097/MEG.0000000000002122
pii: 00042737-202112001-00057
doi:
Substances chimiques
TIMP1 protein, human
0
TIMP2 protein, human
0
Tissue Inhibitor of Metalloproteinase-1
0
Tissue Inhibitor of Metalloproteinase-2
127497-59-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e431-e434Informations de copyright
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
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